EP400 and TBC1D4

Number of citations: 39 (PubMedID 12421765)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		EP400	TBC1D4
Name		E1A binding protein p400	TBC1 domain family member 4
Structure
GO Annotations	Cellular Component	Nucleosome Swr1 Complex Nucleus Nucleoplasm Nuclear Speck NuA4 Histone Acetyltransferase Complex	Cytoplasm Golgi Apparatus Cytosol Vesicle
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity Protein Antigen Binding	GTPase Activator Activity Protein Binding
	Biological Process	DNA Repair Chromatin Organization Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Cellular Response To Insulin Stimulus
Pathways		Formation of Senescence-Associated Heterochromatin Foci (SAHF) DNA Damage/Telomere Stress Induced Senescence HATs acetylate histones	Translocation of SLC2A4 (GLUT4) to the plasma membrane
GWAS		Body mass index ( 26426971 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 27863252 28957414 32888494 )	Diabetic retinopathy ( 23562823 ) Eosinophil count ( 32888494 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Heart failure ( 20445134 ) Mean corpuscular hemoglobin ( 29403010 32888494 ) Mean corpuscular volume ( 27863252 32888494 29403010 ) Mean platelet volume ( 27863252 ) Mean reticulocyte volume ( 32888494 ) Red blood cell count ( 29403010 32888494 27863252 ) Serum alkaline phosphatase levels ( 33547301 ) Two-hour glucose ( 25043022 ) Type 2 diabetes ( 29926116 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )
Interacting Genes		15 interacting genes: ALAS1 ATM BRD8 CEBPA KAT5 MNS1 MYC NTAQ1 POLR1C RAD51 SUMO2 TBC1D4 TRAF2 TRRAP ZGPAT	16 interacting genes: AKT1 CDK5RAP2 EP400 FBXW11 LAMTOR5 NAV1 NFAT5 PIN1 RBM12 RESF1 TASOR TET2 TOPBP1 U2SURP YWHAG ZMIZ1
Entrez ID		57634	9882
HPRD ID		09378	18164
Ensembl ID		ENSG00000183495	ENSG00000136111
Uniprot IDs		Q96L91	O60343
PDB IDs		8QR1 8QRI 8XVG 8XVT 8XVV 9C47 9C57 9C62 9C6N	3QYB 7NIX
GO Terms Enriched among Interactors		Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Recombination Swr1 Complex Nucleoplasm Positive Regulation Of DNA Recombination Regulation Of DNA Repair Positive Regulation Of Double-strand Break Repair NuA4 Histone Acetyltransferase Complex Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of DNA Repair Regulation Of Cell Cycle Cellular Response To Oxygen-containing Compound Response To Xenobiotic Stimulus Site Of Double-strand Break Nucleolus Positive Regulation Of Chromosome Organization Transcription By RNA Polymerase I Nucleosome Protein-containing Complex Binding Positive Regulation Of RNA Biosynthetic Process DNA Double-strand Break Processing Response To X-ray Cellular Response To Gamma Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Recombinational Repair Reciprocal Meiotic Recombination Response To Ionizing Radiation Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA-templated Transcription Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break DNA Repair-dependent Chromatin Remodeling Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Radiation Intrinsic Apoptotic Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Radiation DNA-binding Transcription Factor Binding Homologous Recombination Chromatin Organization Meiosis I	Regulation Of Macromolecule Biosynthetic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Positive Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of Macromolecule Biosynthetic Process Phosphorylation-dependent Protein Binding Positive Regulation Of RNA Biosynthetic Process TOR Signaling Regulation Of Macromolecule Metabolic Process Positive Regulation Of TOR Signaling Positive Regulation Of DNA-templated Transcription Chromatin Organization Positive Regulation Of RNA Metabolic Process Regulation Of TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Leukocyte Cell-cell Adhesion Transposable Element Silencing By Heterochromatin Formation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Protein Localization To Organelle Positive Regulation Of Cell-cell Adhesion Protein K6-linked Ubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Regulation Of TOR Signaling Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Localization To Nucleus Nucleus Establishment Of Mitotic Spindle Orientation Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Microtubule Cytoskeleton Organization Transposable Element Silencing Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Nucleoplasm Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of TRNA Methylation Cis-trans Isomerase Activity Positive Regulation Of Cell Adhesion Regulation Of Mitotic Cell Cycle Regulation Of Cell-cell Adhesion Positive Regulation Of Canonical NF-kappaB Signal Transduction Constitutive Heterochromatin Formation Establishment Of Spindle Localization Regulation Of Intracellular Signal Transduction