Schizophrenia - Wiki-Pi

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide
DPYD and GOPC	dihydropyrimidine dehydrogenase	golgi-associated PDZ and coiled-coil motif containing	Pyrimidine catabolism Pyrimidine metabolism Metabolism of nucleotides		(5s)-5-Iododihydro-2,4(1h,3h)-Pyrimidinedione Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate 6-Carboxymethyluracil Flavin-Adenine Dinucleotide Riboflavin Monophosphate Uracil 5-Iodouracil
DPYD and LXN	dihydropyrimidine dehydrogenase	latexin	Pyrimidine catabolism Pyrimidine metabolism Metabolism of nucleotides		(5s)-5-Iododihydro-2,4(1h,3h)-Pyrimidinedione Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate 6-Carboxymethyluracil Flavin-Adenine Dinucleotide Riboflavin Monophosphate Uracil 5-Iodouracil
GRIN2A and PLCG1	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	phospholipase C, gamma 1	Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses	Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAP12 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Synthesis of IP3 and IP4 in the cytosol Signaling by FGFR1 mutants Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Inositol phosphate metabolism Antiviral mechanism by IFN-stimulated genes EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR TCR signaling Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Signaling by FGFR mutants Frs2-mediated activation Adaptive Immune System Signalling to ERKs Prolonged ERK activation events Axon guidance DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Netrin-1 signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF Generation of second messenger molecules ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PECAM1 interactions Cell surface interactions at the vascular wall Role of second messengers in netrin-1 signaling PLC-gamma1 signalling FCERI mediated Ca+2 mobilization Constitutive Signaling by EGFRvIII Signaling by FGFR1 fusion mutants	L-Glutamic Acid Glycine Meperidine Felbamate Memantine Halothane Tenocyclidine
GRIN2A and AP1M1	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	adaptor-related protein complex 1, mu 1 subunit	Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System	L-Glutamic Acid Glycine Meperidine Felbamate Memantine Halothane Tenocyclidine
GRIN2A and DLGAP1	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	discs, large (Drosophila) homolog-associated protein 1	Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses		L-Glutamic Acid Glycine Meperidine Felbamate Memantine Halothane Tenocyclidine
GRIN2A and RGS3	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	regulator of G-protein signaling 3	Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses		L-Glutamic Acid Glycine Meperidine Felbamate Memantine Halothane Tenocyclidine
GRIN2A and IL16	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	interleukin 16	Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses		L-Glutamic Acid Glycine Meperidine Felbamate Memantine Halothane Tenocyclidine
GRIN2A and SPTAN1	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	spectrin, alpha, non-erythrocytic 1	Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses	Interaction between L1 and Ankyrins Apoptotic cleavage of cellular proteins Axon guidance Programmed Cell Death Apoptotic execution phase Nephrin interactions L1CAM interactions Caspase-mediated cleavage of cytoskeletal proteins NCAM signaling for neurite out-growth	L-Glutamic Acid Glycine Meperidine Felbamate Memantine Halothane Tenocyclidine
GRIN2A and ARHGAP32	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	Rho GTPase activating protein 32	Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses	Rho GTPase cycle Signaling by Rho GTPases	L-Glutamic Acid Glycine Meperidine Felbamate Memantine Halothane Tenocyclidine
GRIN2A and AP4M1	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	adaptor-related protein complex 4, mu 1 subunit	Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses		L-Glutamic Acid Glycine Meperidine Felbamate Memantine Halothane Tenocyclidine
GRIN2A and CASK	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses	Syndecan interactions Nephrin interactions Non-integrin membrane-ECM interactions	L-Glutamic Acid Glycine Meperidine Felbamate Memantine Halothane Tenocyclidine
GRIN2A and NEDD4	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses	Downregulation of ERBB4 signaling Antigen processing: Ubiquitination & Proteasome degradation ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Class I MHC mediated antigen processing & presentation Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Adaptive Immune System	L-Glutamic Acid Glycine Meperidine Felbamate Memantine Halothane Tenocyclidine
GRIN2A and INADL	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	InaD-like (Drosophila)	Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses	Cell junction organization Cell-cell junction organization Tight junction interactions	L-Glutamic Acid Glycine Meperidine Felbamate Memantine Halothane Tenocyclidine
GSTA1 and ST3GAL1	glutathione S-transferase alpha 1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	Keratan sulfate/keratin metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Defective MGAT2 causes MGAT2-CDG (CDG-2a) O-linked glycosylation Defective CHST14 causes EDS, musculocontractural type Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 Glycogen storage diseases Defective ALG2 causes ALG2-CDG (CDG-1i) Keratan sulfate biosynthesis Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective EXT2 causes exostoses 2 Termination of O-glycan biosynthesis Synthesis of substrates in N-glycan biosythesis Asparagine N-linked glycosylation MPS IV - Morquio syndrome A Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Metabolism of carbohydrates O-linked glycosylation of mucins Diseases associated with N-glycosylation of proteins MPS VI - Maroteaux-Lamy syndrome MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective SLC26A2 causes chondrodysplasias Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective PAPSS2 causes SEMD-PA Defective MAN1B1 causes MRT15 MPS IIIA - Sanfilippo syndrome A Defective ALG11 causes ALG11-CDG (CDG-1p) MPS IIIC - Sanfilippo syndrome C Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective ALG8 causes ALG8-CDG (CDG-1h) Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B Defective ALG12 causes ALG12-CDG (CDG-1g) MPS VII - Sly syndrome	Glutathione S-Hydroxycysteine 2-Hydroxyethyl Disulfide N-(4-Aminobutanoyl)-S-(4-Methoxybenzyl)-L-Cysteinylglycine Glutathione Sulfonic Acid S-Benzyl-Glutathione S-Hexylglutathione
KCNJ11 and KCNJ2	potassium channel, inwardly rectifying subfamily J, member 11	potassium channel, inwardly rectifying subfamily J, member 2	Inwardly rectifying K+ channels Integration of energy metabolism ATP sensitive Potassium channels Regulation of insulin secretion Potassium Channels	GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Classical Kir channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses	Glimepiride Ibutilide Verapamil Levosimendan Glyburide Diazoxide Thiamylal
TOP1 and PPP2R2B	topoisomerase (DNA) I	protein phosphatase 2, regulatory subunit B, beta			Irinotecan Topotecan Camptothecin Lucanthone Sodium stibogluconate 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE
RARA and HDAC4	retinoic acid receptor, alpha	histone deacetylase 4	Generic Transcription Pathway Signaling by Retinoic Acid Nuclear Receptor transcription pathway Orphan transporters	Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Adapalene Acitretin Alitretinoin Tazarotene Etretinate Isotretinoin Tamibarotene
RARA and PHF8	retinoic acid receptor, alpha	PHD finger protein 8	Generic Transcription Pathway Signaling by Retinoic Acid Nuclear Receptor transcription pathway Orphan transporters	Chromatin modifying enzymes Chromatin organization HDMs demethylate histones	Adapalene Acitretin Alitretinoin Tazarotene Etretinate Isotretinoin Tamibarotene
TUBB and DISC1	tubulin, beta class I	disrupted in schizophrenia 1	Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic		Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Epothilone B
CDK1 and IL3RA	cyclin-dependent kinase 1	interleukin 3 receptor, alpha (low affinity)	Phosphorylation of the APC/C Signaling by FGFR in disease Phosphorylation of Emi1 Signaling by EGFRvIII in Cancer Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Mitotic G1-G1/S phases SHC-mediated signalling Recruitment of mitotic centrosome proteins and complexes TRIF-mediated TLR3/TLR4 signaling ERK1 activation Nuclear Pore Complex (NPC) Disassembly APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase ERK1 activation APC/C:Cdc20 mediated degradation of Cyclin B Signaling by VEGF Resolution of Sister Chromatid Cohesion Downstream signal transduction Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Interleukin-2 signaling Mitotic G2-G2/M phases Frs2-mediated activation MASTL Facilitates Mitotic Progression Axon guidance IRS-mediated signalling G2/M Transition VEGFA-VEGFR2 Pathway Activated TLR4 signalling VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling Cyclin A/B1 associated events during G2/M transition Loss of Nlp from mitotic centrosomes MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Condensation of Prometaphase Chromosomes Signaling by Insulin receptor E2F mediated regulation of DNA replication Insulin receptor signalling cascade Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes G0 and Early G1 Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) E2F-enabled inhibition of pre-replication complex formation Regulation of mitotic cell cycle Cell Cycle Checkpoints Signaling by GPCR G2/M Checkpoints Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization FCERI mediated MAPK activation Regulation of PLK1 Activity at G2/M Transition SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling G1/S Transition G1/S-Specific Transcription Toll Like Receptor 9 (TLR9) Cascade G2/M DNA replication checkpoint Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 APC/C-mediated degradation of cell cycle proteins Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Condensation of Prophase Chromosomes Signaling by Leptin Signalling to ERKs Mitotic Prometaphase Prolonged ERK activation events Organelle biogenesis and maintenance ERK activation Toll Like Receptor 7/8 (TLR7/8) Cascade Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown IGF1R signaling cascade Recruitment of NuMA to mitotic centrosomes Cyclin B2 mediated events Toll Like Receptor TLR6:TLR2 Cascade M Phase IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Signalling by NGF SOS-mediated signalling G2/M DNA damage checkpoint MAP kinase activation in TLR cascade SHC-mediated signalling Depolymerisation of the Nuclear Lamina Assembly of the primary cilium Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic SHC1 events in EGFR signaling Loss of proteins required for interphase microtubule organizationÂ from the centrosome FRS2-mediated cascade IRS-mediated signalling Centrosome maturation	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Indirubin-3\'-Monoxime Olomoucine Hymenialdisine SU9516 Flavopiridol Alsterpaullone	Sargramostim

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