GSTA1 and ST3GAL1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GSTA1	ST3GAL1
Description		glutathione S-transferase alpha 1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Golgi Membrane Extracellular Region Golgi Apparatus Membrane Golgi Cisterna Membrane Trans-Golgi Network Membrane Extracellular Exosome Golgi Medial Cisterna Membrane Golgi Trans Cisterna Membrane
	Molecular Function	Glutathione Transferase Activity Peroxidase Activity Glutathione Peroxidase Activity Steroid Delta-isomerase Activity Fatty Acid Binding Protein Binding Oxidoreductase Activity Transferase Activity Isomerase Activity	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity Transferase Activity Glycosyltransferase Activity Beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide Alpha-2,3- Sialyltransferase
	Biological Process	Lipid Metabolic Process Prostaglandin Metabolic Process Glutathione Metabolic Process Xenobiotic Metabolic Process Epithelial Cell Differentiation Linoleic Acid Metabolic Process Cellular Oxidant Detoxification Glutathione Derivative Biosynthetic Process	Memory B Cell Differentiation N-acetylneuraminate Metabolic Process Protein Glycosylation Protein N-linked Glycosylation Lipid Metabolic Process Ganglioside Biosynthetic Process Via Lactosylceramide Protein O-linked Glycosylation Via N-acetyl-galactosamine Keratan Sulfate Proteoglycan Biosynthetic Process Viral Protein Processing Protein Modification Process Sialylation Negative Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Protein Sialylation
Pathways		Glutathione conjugation Heme degradation Azathioprine ADME NFE2L2 regulating anti-oxidant/detoxification enzymes	Keratan sulfate biosynthesis Sialic acid metabolism Maturation of protein 3a Maturation of spike protein Maturation of protein 3a Termination of O-glycan biosynthesis
Drugs		Glutathione S-Hydroxycysteine 2-Hydroxyethyl Disulfide N-(4-Aminobutanoyl)-S-(4-methoxybenzyl)-L-cysteinylglycine Glutathione sulfonic acid Glutathione disulfide S-benzylglutathione Deoxycholic acid S-Hexylglutathione Hypericin
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 33339817)	Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Frontal fibrosing alopecia ( 30850646) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Heel bone mineral density x serum urate levels interaction ( 34046847) Intraocular pressure ( 24002674) Personality dimensions ( 23903073) Problematic alcohol use in trauma-exposed individuals ( 29082582) Response to protease inhibitor treatment in hepatitis c (peak serum total bilirubin levels) ( 24503447) Schizophrenia (negative symptoms) ( 23382809) Squamous cell carcinoma ( 26908436)
Interacting Genes		7 interacting genes: APP GSTA2 LSM3 PPP2CB RPAIN ST3GAL1 YWHAE	1 interacting genes: GSTA1
Entrez ID		2938	6482
HPRD ID		00708	06219
Ensembl ID		ENSG00000243955	ENSG00000008513
Uniprot IDs		A0A140VJK4 B7Z1F9 P08263	Q11201
PDB IDs		1GSD 1GSE 1GSF 1GUH 1K3L 1K3O 1K3Y 1LBK 1PKW 1PKZ 1PL1 1PL2 1USB 1XWG 1YDK 2R3X 2R6K 3I69 3I6A 3IK9 3KTL 3L0H 3Q74 3U6V 3ZFB 3ZFL 4HJ2 5JCU 5LCZ 5LD0 6ATO 6ATP 6ATQ 6ATR 6YAW 7BIB 7BIC 8BHC 8BHE
Enriched GO Terms of Interacting Partners?		Response To Lead Ion Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Trans-Golgi Network Membrane Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Golgi Medial Cisterna Membrane Negative Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Protein Sialylation Beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide Alpha-2,3- Sialyltransferase Golgi Trans Cisterna Membrane Memory B Cell Differentiation Regulation Of Heart Rate By Hormone U6 SnRNA 3'-end Binding Regulation Of Calcium Ion Transmembrane Transport Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Cell Activation Involved In Immune Response Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Transmembrane Transporter Binding Ganglioside Biosynthetic Process Via Lactosylceramide Regulation Of Heart Rate By Chemical Signal Negative Regulation Of Calcium Ion Export Across Plasma Membrane Lsm1-7-Pat1 Complex Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of Neurofibrillary Tangle Assembly	Glutathione Derivative Biosynthetic Process Steroid Delta-isomerase Activity Apical Cytoplasm Protein Localization To Motile Cilium Glutathione Peroxidase Activity Linoleic Acid Metabolic Process Dynein Axonemal Particle Outer Dynein Arm Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Inner Dynein Arm Assembly Cerebrospinal Fluid Circulation Reproductive System Development Glutathione Transferase Activity Peroxidase Activity Fatty Acid Binding Prostanoid Metabolic Process Prostaglandin Metabolic Process Axonemal Dynein Complex Assembly Motile Cilium Assembly Epithelial Cilium Movement Involved In Extracellular Fluid Movement Extracellular Transport Glutathione Metabolic Process Protein Localization To Cilium Cellular Oxidant Detoxification Sulfur Compound Biosynthetic Process Xenobiotic Metabolic Process Cellular Detoxification Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Icosanoid Metabolic Process Male Gonad Development Sperm Motility Flagellated Sperm Motility Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility Olefinic Compound Metabolic Process Gonad Development Isomerase Activity Modified Amino Acid Metabolic Process Cilium Movement
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