GABRR1 and PRKACA |
gamma-aminobutyric acid (GABA) A receptor, rho 1 |
protein kinase, cAMP-dependent, catalytic, alpha |
- GABA receptor activation
- GABA A (rho) receptor activation
- Ion channel transport
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Ligand-gated ion channel transport
- Transmission across Chemical Synapses
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- Signaling by GPCR
- Ca-dependent events
- CaM pathway
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Metabolism of lipids and lipoproteins
- Integration of energy metabolism
- Hedgehog 'off' state
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Regulation of PLK1 Activity at G2/M Transition
- PLCG1 events in ERBB2 signaling
- Gluconeogenesis
- Glucose metabolism
- DAP12 signaling
- Rap1 signalling
- Myoclonic epilepsy of Lafora
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- Glycogen storage diseases
- PKA-mediated phosphorylation of key metabolic factors
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Recruitment of mitotic centrosome proteins and complexes
- Glucagon signaling in metabolic regulation
- Signaling by PDGF
- Calmodulin induced events
- DAP12 interactions
- PKA-mediated phosphorylation of CREB
- Opioid Signalling
- PKA activation
- Factors involved in megakaryocyte development and platelet production
- Aquaporin-mediated transport
- CREB phosphorylation through the activation of Adenylate Cyclase
- EGFR interacts with phospholipase C-gamma
- Signaling by ERBB2
- PKA-mediated phosphorylation of CREB
- Signaling by EGFR
- Signaling by Interleukins
- Signaling by VEGF
- Downstream signal transduction
- Calmodulin induced events
- Signaling by EGFR in Cancer
- Metabolism of carbohydrates
- PKA activation
- Interleukin-3, 5 and GM-CSF signaling
- Mitotic G2-G2/M phases
- Transmission across Chemical Synapses
- Adaptive Immune System
- Organelle biogenesis and maintenance
- G2/M Transition
- VEGFA-VEGFR2 Pathway
- DAG and IP3 signaling
- CaM pathway
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Loss of Nlp from mitotic centrosomes
- Downstream signaling of activated FGFR
- DARPP-32 events
- Post NMDA receptor activation events
- Innate Immune System
- PKA activation in glucagon signalling
- Signalling by NGF
- PLC beta mediated events
- Vasopressin regulates renal water homeostasis via Aquaporins
- Regulation of insulin secretion
- Cytokine Signaling in Immune system
- Assembly of the primary cilium
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Lipid digestion, mobilization, and transport
- NGF signalling via TRKA from the plasma membrane
- G-protein mediated events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Anchoring of the basal body to the plasma membrane
- Cell Cycle, Mitotic
- Signaling by FGFR
- Loss of proteins required for interphase microtubule organization from the centrosome
- PLC-gamma1 signalling
- Signaling by Hedgehog
- Degradation of GLI1 by the proteasome
- Centrosome maturation
- GLI3 is processed to GLI3R by the proteasome
- Degradation of GLI2 by the proteasome
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- Lorazepam
- Temazepam
- Clobazam
- Alprazolam
- Picrotoxin
- Chlordiazepoxide
- Adinazolam
- Clorazepate
- Midazolam
- Flurazepam
- Halazepam
- Diazepam
- Oxazepam
- Triazolam
- Clonazepam
- Estazolam
- Bromazepam
- Clotiazepam
- Fludiazepam
- Prazepam
- Quazepam
- Cinolazepam
- Nitrazepam
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GSK3B and NFKB1 |
glycogen synthase kinase 3 beta |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
- Signaling by the B Cell Receptor (BCR)
- Hedgehog 'off' state
- Signaling by FGFR in disease
- misspliced GSK3beta mutants stabilize beta-catenin
- T41 mutants of beta-catenin aren't phosphorylated
- TCF7L2 mutants don't bind CTBP
- truncated APC mutants destabilize the destruction complex
- Signaling by Wnt
- AKT phosphorylates targets in the cytosol
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- DAP12 signaling
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- PI3K/AKT activation
- PI-3K cascade
- RNF mutants show enhanced WNT signaling and proliferation
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Beta-catenin phosphorylation cascade
- truncations of AMER1 destabilize the destruction complex
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Signaling by EGFR
- deletions in the AMER1 gene destabilize the destruction complex
- AMER1 mutants destabilize the destruction complex
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- PI3K/AKT Signaling in Cancer
- CRMPs in Sema3A signaling
- Adaptive Immune System
- Axon guidance
- PIP3 activates AKT signaling
- APC truncation mutants have impaired AXIN binding
- APC truncation mutants are not K63 polyubiquitinated
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- S37 mutants of beta-catenin aren't phosphorylated
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- XAV939 inhibits tankyrase, stabilizing AXIN
- Innate Immune System
- Signalling by NGF
- Semaphorin interactions
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Regulation of HSF1-mediated heat shock response
- Cellular response to heat stress
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- TCF dependent signaling in response to WNT
- Signaling by Hedgehog
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Degradation of GLI2 by the proteasome
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- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- Downstream TCR signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Cellular Senescence
- RIP-mediated NFkB activation via ZBP1
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- Transcriptional regulation of white adipocyte differentiation
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Regulated proteolysis of p75NTR
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- Cytosolic sensors of pathogen-associated DNA
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- p75 NTR receptor-mediated signalling
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Signaling by Interleukins
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Interleukin-1 processing
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Activation of NF-kappaB in B cells
- Fc epsilon receptor (FCERI) signaling
- TRAF6 mediated NF-kB activation
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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- Lithium
- 3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione
- I-5
- N-(4-Methoxybenzyl)-N\'-(5-Nitro-1,3-Thiazol-2-Yl)Urea
- Staurosporine
- Indirubin-3\'-Monoxime
- Adenosine-5\'-Diphosphate
- (3e)-6\'-Bromo-2,3\'-Biindole-2\',3(1h,1\'h)-Dione 3-Oxime
- Alsterpaullone
- Phosphoaminophosphonic Acid-Adenylate Ester
- 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole
- 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione
- (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
- 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2\'H-2,3\'-biindol-2\'-one
- N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
- 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
- ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
- (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
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- Thalidomide
- Pranlukast
- Triflusal
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GSK3B and HDAC4 |
glycogen synthase kinase 3 beta |
histone deacetylase 4 |
- Signaling by the B Cell Receptor (BCR)
- Hedgehog 'off' state
- Signaling by FGFR in disease
- misspliced GSK3beta mutants stabilize beta-catenin
- T41 mutants of beta-catenin aren't phosphorylated
- TCF7L2 mutants don't bind CTBP
- truncated APC mutants destabilize the destruction complex
- Signaling by Wnt
- AKT phosphorylates targets in the cytosol
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- DAP12 signaling
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- PI3K/AKT activation
- PI-3K cascade
- RNF mutants show enhanced WNT signaling and proliferation
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Beta-catenin phosphorylation cascade
- truncations of AMER1 destabilize the destruction complex
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Signaling by EGFR
- deletions in the AMER1 gene destabilize the destruction complex
- AMER1 mutants destabilize the destruction complex
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- PI3K/AKT Signaling in Cancer
- CRMPs in Sema3A signaling
- Adaptive Immune System
- Axon guidance
- PIP3 activates AKT signaling
- APC truncation mutants have impaired AXIN binding
- APC truncation mutants are not K63 polyubiquitinated
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- S37 mutants of beta-catenin aren't phosphorylated
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- XAV939 inhibits tankyrase, stabilizing AXIN
- Innate Immune System
- Signalling by NGF
- Semaphorin interactions
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Regulation of HSF1-mediated heat shock response
- Cellular response to heat stress
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- TCF dependent signaling in response to WNT
- Signaling by Hedgehog
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Degradation of GLI2 by the proteasome
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by NOTCH1
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
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- Lithium
- 3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione
- I-5
- N-(4-Methoxybenzyl)-N\'-(5-Nitro-1,3-Thiazol-2-Yl)Urea
- Staurosporine
- Indirubin-3\'-Monoxime
- Adenosine-5\'-Diphosphate
- (3e)-6\'-Bromo-2,3\'-Biindole-2\',3(1h,1\'h)-Dione 3-Oxime
- Alsterpaullone
- Phosphoaminophosphonic Acid-Adenylate Ester
- 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole
- 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione
- (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
- 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2\'H-2,3\'-biindol-2\'-one
- N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
- 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
- ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
- (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
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GSK3B and BAG6 |
glycogen synthase kinase 3 beta |
BCL2-associated athanogene 6 |
- Signaling by the B Cell Receptor (BCR)
- Hedgehog 'off' state
- Signaling by FGFR in disease
- misspliced GSK3beta mutants stabilize beta-catenin
- T41 mutants of beta-catenin aren't phosphorylated
- TCF7L2 mutants don't bind CTBP
- truncated APC mutants destabilize the destruction complex
- Signaling by Wnt
- AKT phosphorylates targets in the cytosol
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- DAP12 signaling
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- PI3K/AKT activation
- PI-3K cascade
- RNF mutants show enhanced WNT signaling and proliferation
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Beta-catenin phosphorylation cascade
- truncations of AMER1 destabilize the destruction complex
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Signaling by EGFR
- deletions in the AMER1 gene destabilize the destruction complex
- AMER1 mutants destabilize the destruction complex
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- PI3K/AKT Signaling in Cancer
- CRMPs in Sema3A signaling
- Adaptive Immune System
- Axon guidance
- PIP3 activates AKT signaling
- APC truncation mutants have impaired AXIN binding
- APC truncation mutants are not K63 polyubiquitinated
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- S37 mutants of beta-catenin aren't phosphorylated
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- XAV939 inhibits tankyrase, stabilizing AXIN
- Innate Immune System
- Signalling by NGF
- Semaphorin interactions
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Regulation of HSF1-mediated heat shock response
- Cellular response to heat stress
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- TCF dependent signaling in response to WNT
- Signaling by Hedgehog
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Degradation of GLI2 by the proteasome
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- Lithium
- 3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione
- I-5
- N-(4-Methoxybenzyl)-N\'-(5-Nitro-1,3-Thiazol-2-Yl)Urea
- Staurosporine
- Indirubin-3\'-Monoxime
- Adenosine-5\'-Diphosphate
- (3e)-6\'-Bromo-2,3\'-Biindole-2\',3(1h,1\'h)-Dione 3-Oxime
- Alsterpaullone
- Phosphoaminophosphonic Acid-Adenylate Ester
- 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole
- 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione
- (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
- 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2\'H-2,3\'-biindol-2\'-one
- N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
- 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
- ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
- (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
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KDR and NRP1 |
kinase insert domain receptor |
neuropilin 1 |
- VEGF binds to VEGFR leading to receptor dimerization
- EPHA-mediated growth cone collapse
- VEGF ligand-receptor interactions
- Axon guidance
- VEGFR2 mediated cell proliferation
- Signaling by VEGF
- EPH-Ephrin signaling
- Neurophilin interactions with VEGF and VEGFR
- Integrin cell surface interactions
- VEGFA-VEGFR2 Pathway
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- Signal transduction by L1
- CHL1 interactions
- Axon guidance
- Semaphorin interactions
- Signaling by VEGF
- Sema3A PAK dependent Axon repulsion
- Neurophilin interactions with VEGF and VEGFR
- L1CAM interactions
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- CRMPs in Sema3A signaling
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- Sorafenib
- Sunitinib
- N-(4-{4-AMINO-6-[4-(METHYLOXY)PHENYL]FURO[2,3-D]PYRIMIDIN-5-YL}PHENYL)-N\'-[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]UREA
- Pazopanib
- Axitinib
- 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide
- N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide
- N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide
- 6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide
- N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE
- N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE
- 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one
- 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one
- N\'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide
- N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
- N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
- Cabozantinib
- Regorafenib
- Ponatinib
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GRIN3A and GRIN2A |
glutamate receptor, ionotropic, N-methyl-D-aspartate 3A |
glutamate receptor, ionotropic, N-methyl D-aspartate 2A |
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- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- CREB phosphorylation through the activation of CaMKII
- CREB phosphorylation through the activation of Ras
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Unblocking of NMDA receptor, glutamate binding and activation
- Ras activation uopn Ca2+ infux through NMDA receptor
- Post NMDA receptor activation events
- Transmission across Chemical Synapses
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- L-Glutamic Acid
- Tramadol
- Methadone
- Ethopropazine
- Dextromethorphan
- Acamprosate
- Procaine
- Ethanol
- Amantadine
- Felbamate
- Memantine
- Halothane
- Chloroprocaine
- Orphenadrine
- Ketamine
- Tenocyclidine
- Rolicyclidine
- Phencyclidine
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- L-Glutamic Acid
- Glycine
- Meperidine
- Felbamate
- Memantine
- Halothane
- Tenocyclidine
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CACNA1C and GNB1 |
calcium channel, voltage-dependent, L type, alpha 1C subunit |
guanine nucleotide binding protein (G protein), beta polypeptide 1 |
- NCAM1 interactions
- Axon guidance
- Integration of energy metabolism
- Regulation of insulin secretion
- NCAM signaling for neurite out-growth
- Adrenaline,noradrenaline inhibits insulin secretion
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- Signaling by GPCR
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- ADP signalling through P2Y purinoceptor 1
- Integration of energy metabolism
- G alpha (s) signalling events
- Activation of GABAB receptors
- Glucagon-type ligand receptors
- G beta:gamma signalling through PLC beta
- Signaling by Wnt
- Metabolic disorders of biological oxidation enzymes
- G protein gated Potassium channels
- Olfactory Signaling Pathway
- Gastrin-CREB signalling pathway via PKC and MAPK
- Thromboxane signalling through TP receptor
- G alpha (z) signalling events
- G alpha (i) signalling events
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- ADP signalling through P2Y purinoceptor 12
- Glucagon signaling in metabolic regulation
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Inwardly rectifying K+ channels
- G-protein beta:gamma signalling
- Opioid Signalling
- Activation of Kainate Receptors upon glutamate binding
- Diseases associated with visual transduction
- Aquaporin-mediated transport
- Adrenaline,noradrenaline inhibits insulin secretion
- G alpha (q) signalling events
- GPCR downstream signaling
- Platelet homeostasis
- Platelet activation, signaling and aggregation
- Transmission across Chemical Synapses
- G alpha (q) signalling events
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signal amplification
- Potassium Channels
- Activation of the phototransduction cascade
- Inactivation, recovery and regulation of the phototransduction cascade
- G beta:gamma signalling through PI3Kgamma
- The phototransduction cascade
- G alpha (12/13) signalling events
- Class B/2 (Secretin family receptors)
- Prostacyclin signalling through prostacyclin receptor
- GABA B receptor activation
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Vasopressin regulates renal water homeostasis via Aquaporins
- Regulation of insulin secretion
- GPCR ligand binding
- beta-catenin independent WNT signaling
- Thrombin signalling through proteinase activated receptors (PARs)
- Presynaptic function of Kainate receptors
- Visual phototransduction
- Ca2+ pathway
- G-protein activation
|
- Isradipine
- Ibutilide
- Amlodipine
- Nimodipine
- Nisoldipine
- Cinnarizine
- Nicardipine
- Magnesium Sulfate
- Verapamil
- Felodipine
- Nitrendipine
- Nifedipine
- Calcium
- Mibefradil
- Dronedarone
- Clevidipine
- Nilvadipine
- Drotaverine
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|
|
|
CACNA1C and PCBD1 |
calcium channel, voltage-dependent, L type, alpha 1C subunit |
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha |
- NCAM1 interactions
- Axon guidance
- Integration of energy metabolism
- Regulation of insulin secretion
- NCAM signaling for neurite out-growth
- Adrenaline,noradrenaline inhibits insulin secretion
|
- Phenylalanine and tyrosine catabolism
- Metabolism of amino acids and derivatives
|
- Isradipine
- Ibutilide
- Amlodipine
- Nimodipine
- Nisoldipine
- Cinnarizine
- Nicardipine
- Magnesium Sulfate
- Verapamil
- Felodipine
- Nitrendipine
- Nifedipine
- Calcium
- Mibefradil
- Dronedarone
- Clevidipine
- Nilvadipine
- Drotaverine
|
|
|
|
CACNA1C and CABP1 |
calcium channel, voltage-dependent, L type, alpha 1C subunit |
calcium binding protein 1 |
- NCAM1 interactions
- Axon guidance
- Integration of energy metabolism
- Regulation of insulin secretion
- NCAM signaling for neurite out-growth
- Adrenaline,noradrenaline inhibits insulin secretion
|
|
- Isradipine
- Ibutilide
- Amlodipine
- Nimodipine
- Nisoldipine
- Cinnarizine
- Nicardipine
- Magnesium Sulfate
- Verapamil
- Felodipine
- Nitrendipine
- Nifedipine
- Calcium
- Mibefradil
- Dronedarone
- Clevidipine
- Nilvadipine
- Drotaverine
|
|
|
|
CACNA1C and RIMS1 |
calcium channel, voltage-dependent, L type, alpha 1C subunit |
regulating synaptic membrane exocytosis 1 |
- NCAM1 interactions
- Axon guidance
- Integration of energy metabolism
- Regulation of insulin secretion
- NCAM signaling for neurite out-growth
- Adrenaline,noradrenaline inhibits insulin secretion
|
- Dopamine Neurotransmitter Release Cycle
- Neurotransmitter Release Cycle
- Acetylcholine Neurotransmitter Release Cycle
- Norepinephrine Neurotransmitter Release Cycle
- Serotonin Neurotransmitter Release Cycle
- GABA synthesis, release, reuptake and degradation
- Glutamate Neurotransmitter Release Cycle
- Transmission across Chemical Synapses
|
- Isradipine
- Ibutilide
- Amlodipine
- Nimodipine
- Nisoldipine
- Cinnarizine
- Nicardipine
- Magnesium Sulfate
- Verapamil
- Felodipine
- Nitrendipine
- Nifedipine
- Calcium
- Mibefradil
- Dronedarone
- Clevidipine
- Nilvadipine
- Drotaverine
|
|
|
|
CACNA1C and COPS5 |
calcium channel, voltage-dependent, L type, alpha 1C subunit |
COP9 signalosome subunit 5 |
- NCAM1 interactions
- Axon guidance
- Integration of energy metabolism
- Regulation of insulin secretion
- NCAM signaling for neurite out-growth
- Adrenaline,noradrenaline inhibits insulin secretion
|
|
- Isradipine
- Ibutilide
- Amlodipine
- Nimodipine
- Nisoldipine
- Cinnarizine
- Nicardipine
- Magnesium Sulfate
- Verapamil
- Felodipine
- Nitrendipine
- Nifedipine
- Calcium
- Mibefradil
- Dronedarone
- Clevidipine
- Nilvadipine
- Drotaverine
|
|
|
|
CACNA1C and CACNB3 |
calcium channel, voltage-dependent, L type, alpha 1C subunit |
calcium channel, voltage-dependent, beta 3 subunit |
- NCAM1 interactions
- Axon guidance
- Integration of energy metabolism
- Regulation of insulin secretion
- NCAM signaling for neurite out-growth
- Adrenaline,noradrenaline inhibits insulin secretion
|
- NCAM1 interactions
- Axon guidance
- Integration of energy metabolism
- Regulation of insulin secretion
- NCAM signaling for neurite out-growth
- Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
- Transmission across Chemical Synapses
- Adrenaline,noradrenaline inhibits insulin secretion
|
- Isradipine
- Ibutilide
- Amlodipine
- Nimodipine
- Nisoldipine
- Cinnarizine
- Nicardipine
- Magnesium Sulfate
- Verapamil
- Felodipine
- Nitrendipine
- Nifedipine
- Calcium
- Mibefradil
- Dronedarone
- Clevidipine
- Nilvadipine
- Drotaverine
|
|
|
|
CACNA1C and PRKACA |
calcium channel, voltage-dependent, L type, alpha 1C subunit |
protein kinase, cAMP-dependent, catalytic, alpha |
- NCAM1 interactions
- Axon guidance
- Integration of energy metabolism
- Regulation of insulin secretion
- NCAM signaling for neurite out-growth
- Adrenaline,noradrenaline inhibits insulin secretion
|
- Signaling by GPCR
- Ca-dependent events
- CaM pathway
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Metabolism of lipids and lipoproteins
- Integration of energy metabolism
- Hedgehog 'off' state
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Regulation of PLK1 Activity at G2/M Transition
- PLCG1 events in ERBB2 signaling
- Gluconeogenesis
- Glucose metabolism
- DAP12 signaling
- Rap1 signalling
- Myoclonic epilepsy of Lafora
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- Glycogen storage diseases
- PKA-mediated phosphorylation of key metabolic factors
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Recruitment of mitotic centrosome proteins and complexes
- Glucagon signaling in metabolic regulation
- Signaling by PDGF
- Calmodulin induced events
- DAP12 interactions
- PKA-mediated phosphorylation of CREB
- Opioid Signalling
- PKA activation
- Factors involved in megakaryocyte development and platelet production
- Aquaporin-mediated transport
- CREB phosphorylation through the activation of Adenylate Cyclase
- EGFR interacts with phospholipase C-gamma
- Signaling by ERBB2
- PKA-mediated phosphorylation of CREB
- Signaling by EGFR
- Signaling by Interleukins
- Signaling by VEGF
- Downstream signal transduction
- Calmodulin induced events
- Signaling by EGFR in Cancer
- Metabolism of carbohydrates
- PKA activation
- Interleukin-3, 5 and GM-CSF signaling
- Mitotic G2-G2/M phases
- Transmission across Chemical Synapses
- Adaptive Immune System
- Organelle biogenesis and maintenance
- G2/M Transition
- VEGFA-VEGFR2 Pathway
- DAG and IP3 signaling
- CaM pathway
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Loss of Nlp from mitotic centrosomes
- Downstream signaling of activated FGFR
- DARPP-32 events
- Post NMDA receptor activation events
- Innate Immune System
- PKA activation in glucagon signalling
- Signalling by NGF
- PLC beta mediated events
- Vasopressin regulates renal water homeostasis via Aquaporins
- Regulation of insulin secretion
- Cytokine Signaling in Immune system
- Assembly of the primary cilium
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Lipid digestion, mobilization, and transport
- NGF signalling via TRKA from the plasma membrane
- G-protein mediated events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Anchoring of the basal body to the plasma membrane
- Cell Cycle, Mitotic
- Signaling by FGFR
- Loss of proteins required for interphase microtubule organization from the centrosome
- PLC-gamma1 signalling
- Signaling by Hedgehog
- Degradation of GLI1 by the proteasome
- Centrosome maturation
- GLI3 is processed to GLI3R by the proteasome
- Degradation of GLI2 by the proteasome
|
- Isradipine
- Ibutilide
- Amlodipine
- Nimodipine
- Nisoldipine
- Cinnarizine
- Nicardipine
- Magnesium Sulfate
- Verapamil
- Felodipine
- Nitrendipine
- Nifedipine
- Calcium
- Mibefradil
- Dronedarone
- Clevidipine
- Nilvadipine
- Drotaverine
|
|
|
|
CACNA1C and RYR2 |
calcium channel, voltage-dependent, L type, alpha 1C subunit |
ryanodine receptor 2 (cardiac) |
- NCAM1 interactions
- Axon guidance
- Integration of energy metabolism
- Regulation of insulin secretion
- NCAM signaling for neurite out-growth
- Adrenaline,noradrenaline inhibits insulin secretion
|
- Ion channel transport
- Stimuli-sensing channels
|
- Isradipine
- Ibutilide
- Amlodipine
- Nimodipine
- Nisoldipine
- Cinnarizine
- Nicardipine
- Magnesium Sulfate
- Verapamil
- Felodipine
- Nitrendipine
- Nifedipine
- Calcium
- Mibefradil
- Dronedarone
- Clevidipine
- Nilvadipine
- Drotaverine
|
|
|
|
CACNA1C and PPM1A |
calcium channel, voltage-dependent, L type, alpha 1C subunit |
protein phosphatase, Mg2+/Mn2+ dependent, 1A |
- NCAM1 interactions
- Axon guidance
- Integration of energy metabolism
- Regulation of insulin secretion
- NCAM signaling for neurite out-growth
- Adrenaline,noradrenaline inhibits insulin secretion
|
- Loss of Function of TGFBR2 in Cancer
- IRS-mediated signalling
- mTOR signalling
- SMAD2/3 MH2 Domain Mutants in Cancer
- mTOR signalling
- TGFBR1 LBD Mutants in Cancer
- IGF1R signaling cascade
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRS-related events triggered by IGF1R
- Generic Transcription Pathway
- Energy dependent regulation of mTOR by LKB1-AMPK
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
- TGFBR2 MSI Frameshift Mutants in Cancer
- Insulin receptor signalling cascade
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- Regulation of AMPK activity via LKB1
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- IRS-related events
- Loss of Function of TGFBR1 in Cancer
- IRS-mediated signalling
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- PKB-mediated events
- PI3K Cascade
- SMAD4 MH2 Domain Mutants in Cancer
|
- Isradipine
- Ibutilide
- Amlodipine
- Nimodipine
- Nisoldipine
- Cinnarizine
- Nicardipine
- Magnesium Sulfate
- Verapamil
- Felodipine
- Nitrendipine
- Nifedipine
- Calcium
- Mibefradil
- Dronedarone
- Clevidipine
- Nilvadipine
- Drotaverine
|
|
|
|
CACNA1C and SRI |
calcium channel, voltage-dependent, L type, alpha 1C subunit |
sorcin |
- NCAM1 interactions
- Axon guidance
- Integration of energy metabolism
- Regulation of insulin secretion
- NCAM signaling for neurite out-growth
- Adrenaline,noradrenaline inhibits insulin secretion
|
- Ion channel transport
- Stimuli-sensing channels
|
- Isradipine
- Ibutilide
- Amlodipine
- Nimodipine
- Nisoldipine
- Cinnarizine
- Nicardipine
- Magnesium Sulfate
- Verapamil
- Felodipine
- Nitrendipine
- Nifedipine
- Calcium
- Mibefradil
- Dronedarone
- Clevidipine
- Nilvadipine
- Drotaverine
|
|
|
|
CACNA1C and HDAC4 |
calcium channel, voltage-dependent, L type, alpha 1C subunit |
histone deacetylase 4 |
- NCAM1 interactions
- Axon guidance
- Integration of energy metabolism
- Regulation of insulin secretion
- NCAM signaling for neurite out-growth
- Adrenaline,noradrenaline inhibits insulin secretion
|
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by NOTCH1
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
|
- Isradipine
- Ibutilide
- Amlodipine
- Nimodipine
- Nisoldipine
- Cinnarizine
- Nicardipine
- Magnesium Sulfate
- Verapamil
- Felodipine
- Nitrendipine
- Nifedipine
- Calcium
- Mibefradil
- Dronedarone
- Clevidipine
- Nilvadipine
- Drotaverine
|
|
|
|
HMGCR and INSIG1 |
3-hydroxy-3-methylglutaryl-CoA reductase |
insulin induced gene 1 |
|
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Metabolism of lipids and lipoproteins
|
- NADH
- Pravastatin
- Lovastatin
- Cerivastatin
- Simvastatin
- Atorvastatin
- Fluvastatin
- Rosuvastatin
- Coenzyme A
- (S)-Hmg-Coa
- Adenosine-5\'-Diphosphate
- 2\'-Monophosphoadenosine 5\'-Diphosphoribose
- 3-Hydroxy-3-Methyl-Glutaric Acid
- 1,4-Dithiothreitol
- Mevastatin
- 7-[3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOL-2-YL]-3,5-DIHYDROXY-HEPTANOIC ACID
- Pitavastatin
|
|
|
|
ABL1 and ROBO1 |
ABL proto-oncogene 1, non-receptor tyrosine kinase |
roundabout, axon guidance receptor, homolog 1 (Drosophila) |
- Role of Abl in Robo-Slit signaling
- CDO in myogenesis
- Axon guidance
- Myogenesis
- Fcgamma receptor (FCGR) dependent phagocytosis
- Factors involved in megakaryocyte development and platelet production
- Signaling by Robo receptor
- Regulation of actin dynamics for phagocytic cup formation
- Innate Immune System
|
- Inactivation of Cdc42 and Rac
- Role of Abl in Robo-Slit signaling
- Axon guidance
- Activation of Rac
- Regulation of Commissural axon pathfinding by Slit and Robo
- Netrin-1 signaling
- Signaling by Robo receptor
|
- Adenosine triphosphate
- Imatinib
- Dasatinib
- N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
- Nilotinib
- Bosutinib
- 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
- 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA
- MYRISTIC ACID
- 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE
- 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE
- 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide
- Regorafenib
- Ponatinib
|
|
|
|
ALOX5 and MAD1L1 |
arachidonate 5-lipoxygenase |
MAD1 mitotic arrest deficient-like 1 (yeast) |
- Arachidonic acid metabolism
- Synthesis of 5-eicosatetraenoic acids
- Metabolism of lipids and lipoproteins
- Synthesis of Lipoxins (LX)
- Synthesis of Leukotrienes (LT) and Eoxins (EX)
|
- Mitotic Spindle Checkpoint
- Amplification of signal from the kinetochores
- Mitotic Prometaphase
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Cell Cycle Checkpoints
- Mitotic Anaphase
- Mitotic Metaphase and Anaphase
- Cell Cycle, Mitotic
- M Phase
|
- Vitamin E
- Masoprocol
- Aminosalicylic Acid
- Mesalazine
- Montelukast
- Diclofenac
- Diethylcarbamazine
- Zileuton
- Sulfasalazine
- Meclofenamic acid
- Balsalazide
- Minocycline
- Hyperforin
- Heme
|
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