CDK1 and KIF26B |
cyclin-dependent kinase 1 |
kinesin family member 26B |
- Phosphorylation of the APC/C
- Signaling by FGFR in disease
- Phosphorylation of Emi1
- Signaling by EGFRvIII in Cancer
- Toll Like Receptor TLR1:TLR2 Cascade
- Toll Like Receptor 5 (TLR5) Cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- MyD88 dependent cascade initiated on endosome
- SOS-mediated signalling
- Mitotic G1-G1/S phases
- SHC-mediated signalling
- Recruitment of mitotic centrosome proteins and complexes
- TRIF-mediated TLR3/TLR4 signaling
- ERK1 activation
- Nuclear Pore Complex (NPC) Disassembly
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Regulation of APC/C activators between G1/S and early anaphase
- ERK1 activation
- APC/C:Cdc20 mediated degradation of Cyclin B
- Signaling by VEGF
- Resolution of Sister Chromatid Cohesion
- Downstream signal transduction
- Signalling to RAS
- Toll Like Receptor 3 (TLR3) Cascade
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
- Interleukin-2 signaling
- Mitotic G2-G2/M phases
- Frs2-mediated activation
- MASTL Facilitates Mitotic Progression
- Axon guidance
- IRS-mediated signalling
- G2/M Transition
- VEGFA-VEGFR2 Pathway
- Activated TLR4 signalling
- VEGFR2 mediated cell proliferation
- GRB2 events in ERBB2 signaling
- Cyclin A/B1 associated events during G2/M transition
- Loss of Nlp from mitotic centrosomes
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Innate Immune System
- Condensation of Prometaphase Chromosomes
- Signaling by Insulin receptor
- E2F mediated regulation of DNA replication
- Insulin receptor signalling cascade
- Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
- G0 and Early G1
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- SHC-related events
- Signaling by FGFR
- ARMS-mediated activation
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- E2F-enabled inhibition of pre-replication complex formation
- Regulation of mitotic cell cycle
- Cell Cycle Checkpoints
- Signaling by GPCR
- G2/M Checkpoints
- Mitotic Prophase
- Golgi Cisternae Pericentriolar Stack Reorganization
- FCERI mediated MAPK activation
- Regulation of PLK1 Activity at G2/M Transition
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- G1/S Transition
- G1/S-Specific Transcription
- Toll Like Receptor 9 (TLR9) Cascade
- G2/M DNA replication checkpoint
- Signaling by PDGF
- DAP12 interactions
- SHC-related events triggered by IGF1R
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- APC/C-mediated degradation of cell cycle proteins
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Condensation of Prophase Chromosomes
- Signaling by Leptin
- Signalling to ERKs
- Mitotic Prometaphase
- Prolonged ERK activation events
- Organelle biogenesis and maintenance
- ERK activation
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Activation of NIMA Kinases NEK9, NEK6, NEK7
- Nuclear Envelope Breakdown
- IGF1R signaling cascade
- Recruitment of NuMA to mitotic centrosomes
- Cyclin B2 mediated events
- Toll Like Receptor TLR6:TLR2 Cascade
- M Phase
- IRS-related events triggered by IGF1R
- MyD88 cascade initiated on plasma membrane
- ERK activation
- Downstream signaling of activated FGFR
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
- Signalling by NGF
- SOS-mediated signalling
- G2/M DNA damage checkpoint
- MAP kinase activation in TLR cascade
- SHC-mediated signalling
- Depolymerisation of the Nuclear Lamina
- Assembly of the primary cilium
- Cytokine Signaling in Immune system
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- MyD88-independent cascade
- Anchoring of the basal body to the plasma membrane
- Cell Cycle, Mitotic
- SHC1 events in EGFR signaling
- Loss of proteins required for interphase microtubule organization from the centrosome
- FRS2-mediated cascade
- IRS-mediated signalling
- Centrosome maturation
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- Indirubin-3\'-Monoxime
- Olomoucine
- Hymenialdisine
- SU9516
- Flavopiridol
- Alsterpaullone
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FGA and PRRC2A |
fibrinogen alpha chain |
proline-rich coiled-coil 2A |
- p130Cas linkage to MAPK signaling for integrins
- Integrin alphaIIb beta3 signaling
- Platelet degranulation
- GRB2:SOS provides linkage to MAPK signaling for Integrins
- Platelet Aggregation (Plug Formation)
- Formation of Fibrin Clot (Clotting Cascade)
- Common Pathway
- Amyloids
- Response to elevated platelet cytosolic Ca2+
- Integrin cell surface interactions
- Platelet activation, signaling and aggregation
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- Alteplase
- Reteplase
- Anistreplase
- Tenecteplase
- Sucralfate
- Alpha-D-Mannose
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FGF2 and NRP1 |
fibroblast growth factor 2 (basic) |
neuropilin 1 |
- Signaling by the B Cell Receptor (BCR)
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- SHC-mediated cascade
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Signaling by FGFR2 mutants
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- PI-3K cascade
- Signaling by activated point mutants of FGFR1
- Signaling by FGFR1 mutants
- PI3K Cascade
- Negative regulation of FGFR signaling
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- Activated point mutants of FGFR2
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- FGFR4 ligand binding and activation
- Syndecan interactions
- Signaling by EGFR
- Signaling by FGFR3 mutants
- Downstream signal transduction
- Signaling by activated point mutants of FGFR3
- Fc epsilon receptor (FCERI) signaling
- Signaling by FGFR mutants
- Signaling by EGFR in Cancer
- PI3K/AKT Signaling in Cancer
- Adaptive Immune System
- IRS-mediated signalling
- PIP3 activates AKT signaling
- IGF1R signaling cascade
- IRS-related events triggered by IGF1R
- Transcriptional regulation of pluripotent stem cells
- PI3K events in ERBB2 signaling
- FGFR1b ligand binding and activation
- Downstream signaling of activated FGFR
- FGFR3c ligand binding and activation
- FGFR1c ligand binding and activation
- FGFR2c ligand binding and activation
- FGFR ligand binding and activation
- POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
- Signaling by Insulin receptor
- Innate Immune System
- Signalling by NGF
- Insulin receptor signalling cascade
- IRS-related events
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Non-integrin membrane-ECM interactions
- FGFR3 ligand binding and activation
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- FGFR2 ligand binding and activation
- FRS2-mediated cascade
- IRS-mediated signalling
- FGFR1 ligand binding and activation
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- PI3K Cascade
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- Signal transduction by L1
- CHL1 interactions
- Axon guidance
- Semaphorin interactions
- Signaling by VEGF
- Sema3A PAK dependent Axon repulsion
- Neurophilin interactions with VEGF and VEGFR
- L1CAM interactions
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- CRMPs in Sema3A signaling
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- Sucralfate
- Pentosan Polysulfate
- Sirolimus
- 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid
- N,O6-Disulfo-Glucosamine
- 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid
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FLT1 and NRP1 |
fms-related tyrosine kinase 1 |
neuropilin 1 |
- VEGF binds to VEGFR leading to receptor dimerization
- VEGF ligand-receptor interactions
- Signaling by VEGF
- Neurophilin interactions with VEGF and VEGFR
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- Signal transduction by L1
- CHL1 interactions
- Axon guidance
- Semaphorin interactions
- Signaling by VEGF
- Sema3A PAK dependent Axon repulsion
- Neurophilin interactions with VEGF and VEGFR
- L1CAM interactions
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- CRMPs in Sema3A signaling
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- Sorafenib
- Sunitinib
- Pazopanib
- Axitinib
- N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide
- Regorafenib
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GLUD1 and LSM1 |
glutamate dehydrogenase 1 |
LSM1, U6 small nuclear RNA associated |
- Amino acid synthesis and interconversion (transamination)
- Metabolism of amino acids and derivatives
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- mRNA decay by 5' to 3' exoribonuclease
- Deadenylation-dependent mRNA decay
|
- L-Glutamic Acid
- NADH
- Hexachlorophene
- Nicotinamide-Adenine-Dinucleotide
- Adenosine-5\'-Diphosphate
- Guanosine-5\'-Triphosphate
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SYK and HDAC4 |
spleen tyrosine kinase |
histone deacetylase 4 |
- Signaling by the B Cell Receptor (BCR)
- FCERI mediated MAPK activation
- Platelet Aggregation (Plug Formation)
- DAP12 signaling
- Regulation of signaling by CBL
- Role of phospholipids in phagocytosis
- Fcgamma receptor (FCGR) dependent phagocytosis
- FCGR activation
- Regulation of actin dynamics for phagocytic cup formation
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Innate Immune System
- DAP12 interactions
- Integrin alphaIIb beta3 signaling
- Cytokine Signaling in Immune system
- Role of LAT2/NTAL/LAB on calcium mobilization
- Signaling by Interleukins
- Fc epsilon receptor (FCERI) signaling
- GPVI-mediated activation cascade
- Interleukin-2 signaling
- FCERI mediated Ca+2 mobilization
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by NOTCH1
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
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- Staurosporine
- N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide
- 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
- 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide
- 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide
- Ellagic Acid
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GAPDH and ANXA1 |
glyceraldehyde-3-phosphate dehydrogenase |
annexin A1 |
- Gluconeogenesis
- Glucose metabolism
- Myoclonic epilepsy of Lafora
- Glycogen storage diseases
- Glycolysis
- Metabolism of carbohydrates
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- G alpha (q) signalling events
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- Class A/1 (Rhodopsin-like receptors)
- GPCR ligand binding
- Metabolic disorders of biological oxidation enzymes
- Formyl peptide receptors bind formyl peptides and many other ligands
- G alpha (q) signalling events
- GPCR downstream signaling
- Peptide ligand-binding receptors
- Gastrin-CREB signalling pathway via PKC and MAPK
- G alpha (i) signalling events
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- NADH
- Nicotinamide-Adenine-Dinucleotide
- Adenosine-5-Diphosphoribose
- Thionicotinamide-Adenine-Dinucleotide
- 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE
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- Amcinonide
- Hydrocortisone
- Dexamethasone
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ELANE and CXCL12 |
elastase, neutrophil expressed |
chemokine (C-X-C motif) ligand 12 |
- Collagen degradation
- Activation of Matrix Metalloproteinases
- Degradation of the extracellular matrix
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- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- Class A/1 (Rhodopsin-like receptors)
- Signaling by ERBB4
- GPCR ligand binding
- Metabolic disorders of biological oxidation enzymes
- GPCR downstream signaling
- Nuclear signaling by ERBB4
- Peptide ligand-binding receptors
- Chemokine receptors bind chemokines
- G alpha (i) signalling events
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- Pegfilgrastim
- Alpha-1-proteinase inhibitor
- Filgrastim
- Mdl 101,146
- ONO-6818
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ERBB2 and ANKS1B |
erb-b2 receptor tyrosine kinase 2 |
ankyrin repeat and sterile alpha motif domain containing 1B |
- Signaling by the B Cell Receptor (BCR)
- Signaling by FGFR in disease
- Axon guidance
- PIP3 activates AKT signaling
- GRB7 events in ERBB2 signaling
- Signaling by EGFRvIII in Cancer
- PLCG1 events in ERBB2 signaling
- Signaling by SCF-KIT
- SHC1 events in ERBB2 signaling
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- PI-3K cascade
- GRB2 events in ERBB2 signaling
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- Sema4D in semaphorin signaling
- Sema4D induced cell migration and growth-cone collapse
- Innate Immune System
- Signaling by PDGF
- Downregulation of ERBB2:ERBB3 signaling
- Signalling by NGF
- DAP12 interactions
- GAB1 signalosome
- Semaphorin interactions
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by ERBB4
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by FGFR
- Signaling by ERBB2
- Signaling by EGFR
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- PI3K/AKT Signaling in Cancer
- Adaptive Immune System
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- Trastuzumab
- Lapatinib
- ado-trastuzumab emtansine
- Pertuzumab
- Afatinib
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ERBB2 and RIN2 |
erb-b2 receptor tyrosine kinase 2 |
Ras and Rab interactor 2 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by FGFR in disease
- Axon guidance
- PIP3 activates AKT signaling
- GRB7 events in ERBB2 signaling
- Signaling by EGFRvIII in Cancer
- PLCG1 events in ERBB2 signaling
- Signaling by SCF-KIT
- SHC1 events in ERBB2 signaling
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- PI-3K cascade
- GRB2 events in ERBB2 signaling
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- Sema4D in semaphorin signaling
- Sema4D induced cell migration and growth-cone collapse
- Innate Immune System
- Signaling by PDGF
- Downregulation of ERBB2:ERBB3 signaling
- Signalling by NGF
- DAP12 interactions
- GAB1 signalosome
- Semaphorin interactions
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by ERBB4
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by FGFR
- Signaling by ERBB2
- Signaling by EGFR
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- PI3K/AKT Signaling in Cancer
- Adaptive Immune System
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- Trastuzumab
- Lapatinib
- ado-trastuzumab emtansine
- Pertuzumab
- Afatinib
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PPIA and TCF4 |
peptidylprolyl isomerase A (cyclophilin A) |
transcription factor 4 |
- HIV Infection
- Host Interactions of HIV factors
- Integration of provirus
- Platelet degranulation
- Basigin interactions
- Late Phase of HIV Life Cycle
- Cell surface interactions at the vascular wall
- Uncoating of the HIV Virion
- Early Phase of HIV Life Cycle
- Reverse Transcription of HIV RNA
- Assembly Of The HIV Virion
- HIV Life Cycle
- Budding and maturation of HIV virion
- Response to elevated platelet cytosolic Ca2+
- Minus-strand DNA synthesis
- Platelet activation, signaling and aggregation
- Binding and entry of HIV virion
- Plus-strand DNA synthesis
- APOBEC3G mediated resistance to HIV-1 infection
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- CDO in myogenesis
- Myogenesis
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- Cyclosporine
- L-Proline
- (3r)-1-Acetyl-3-Methylpiperidine
- Ethyl Oxo(Piperidin-1-Yl)Acetate
- (3s,6s,9r,10r,11s,12s,13e,15e,18s,21s)-18-{(1e,3e,7s,8s)-9-[(2s,3r,4s,5s,6r,9s,11s)-9-Ethyl-4-Hydroxy-3,5,11-Trimethyl-8-Oxo-1-Oxa-7-Azaspiro[5.5]Undec-2-Yl]-8-Hydroxy-1,7-Dimethylnona-1,3-Dienyl}-10,12-Dihydroxy-3-(3-Hydroxybenzyl)-6-Isopropyl-11-Methyl-
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IKBKB and NFKB1 |
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- RIP-mediated NFkB activation via ZBP1
- IRAK1 recruits IKK complex
- Downstream signaling events of B Cell Receptor (BCR)
- Toll Like Receptor TLR1:TLR2 Cascade
- FCERI mediated NF-kB activation
- Toll Like Receptor 5 (TLR5) Cascade
- NOD1/2 Signaling Pathway
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- IRAK1 recruits IKK complex
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 2 (TLR2) Cascade
- TCR signaling
- Signaling by Interleukins
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Fc epsilon receptor (FCERI) signaling
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Downstream TCR signaling
- p75NTR recruits signalling complexes
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Innate Immune System
- Signalling by NGF
- IKK complex recruitment mediated by RIP1
- Cytosolic sensors of pathogen-associated DNA
- p75 NTR receptor-mediated signalling
- Cytokine Signaling in Immune system
- MyD88-independent cascade
- Toll-Like Receptors Cascades
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Activation of NF-kappaB in B cells
- TRAF6 mediated NF-kB activation
- NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
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- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- Downstream TCR signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Cellular Senescence
- RIP-mediated NFkB activation via ZBP1
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- Transcriptional regulation of white adipocyte differentiation
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Regulated proteolysis of p75NTR
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- Cytosolic sensors of pathogen-associated DNA
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- p75 NTR receptor-mediated signalling
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Signaling by Interleukins
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Interleukin-1 processing
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Activation of NF-kappaB in B cells
- Fc epsilon receptor (FCERI) signaling
- TRAF6 mediated NF-kB activation
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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- Mesalazine
- Sulfasalazine
- Auranofin
- Arsenic trioxide
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- Thalidomide
- Pranlukast
- Triflusal
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IL2RA and NFKB1 |
interleukin 2 receptor, alpha |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
- Signaling by GPCR
- G-protein beta:gamma signalling
- Cytokine Signaling in Immune system
- Signaling by Interleukins
- GPCR downstream signaling
- Interleukin receptor SHC signaling
- G beta:gamma signalling through PI3Kgamma
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
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- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- Downstream TCR signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Cellular Senescence
- RIP-mediated NFkB activation via ZBP1
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- Transcriptional regulation of white adipocyte differentiation
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Regulated proteolysis of p75NTR
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- Cytosolic sensors of pathogen-associated DNA
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- p75 NTR receptor-mediated signalling
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Signaling by Interleukins
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Interleukin-1 processing
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Activation of NF-kappaB in B cells
- Fc epsilon receptor (FCERI) signaling
- TRAF6 mediated NF-kB activation
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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- Denileukin diftitox
- Aldesleukin
- Basiliximab
- Daclizumab
|
- Thalidomide
- Pranlukast
- Triflusal
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IKBKB and CSF2RA |
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta |
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) |
- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- RIP-mediated NFkB activation via ZBP1
- IRAK1 recruits IKK complex
- Downstream signaling events of B Cell Receptor (BCR)
- Toll Like Receptor TLR1:TLR2 Cascade
- FCERI mediated NF-kB activation
- Toll Like Receptor 5 (TLR5) Cascade
- NOD1/2 Signaling Pathway
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- IRAK1 recruits IKK complex
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 2 (TLR2) Cascade
- TCR signaling
- Signaling by Interleukins
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Fc epsilon receptor (FCERI) signaling
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Downstream TCR signaling
- p75NTR recruits signalling complexes
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- Activated TLR4 signalling
- MyD88 cascade initiated on plasma membrane
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Innate Immune System
- Signalling by NGF
- IKK complex recruitment mediated by RIP1
- Cytosolic sensors of pathogen-associated DNA
- p75 NTR receptor-mediated signalling
- Cytokine Signaling in Immune system
- MyD88-independent cascade
- Toll-Like Receptors Cascades
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Activation of NF-kappaB in B cells
- TRAF6 mediated NF-kB activation
- NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
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- Signaling by GPCR
- G-protein beta:gamma signalling
- Cytokine Signaling in Immune system
- GPCR downstream signaling
- Signaling by Interleukins
- Interleukin receptor SHC signaling
- G beta:gamma signalling through PI3Kgamma
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
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- Mesalazine
- Sulfasalazine
- Auranofin
- Arsenic trioxide
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PPP1CC and IL3RA |
protein phosphatase 1, catalytic subunit, gamma isozyme |
interleukin 3 receptor, alpha (low affinity) |
- Loss of Function of TGFBR2 in Cancer
- Mitotic Prometaphase
- Metabolism of lipids and lipoproteins
- Separation of Sister Chromatids
- Downregulation of TGF-beta receptor signaling
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGF-beta receptor signaling activates SMADs
- Mitotic Anaphase
- TGFBR1 LBD Mutants in Cancer
- M Phase
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- Lipid digestion, mobilization, and transport
- Cell Cycle, Mitotic
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- Resolution of Sister Chromatid Cohesion
- Mitotic Metaphase and Anaphase
- SMAD4 MH2 Domain Mutants in Cancer
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- Signaling by GPCR
- G-protein beta:gamma signalling
- Cytokine Signaling in Immune system
- GPCR downstream signaling
- Signaling by Interleukins
- Interleukin receptor SHC signaling
- G beta:gamma signalling through PI3Kgamma
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
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- 9,10-Deepithio-9,10-Didehydroacanthifolicin
- Calyculin A
- (2S,5R,8S,11R,12S,15S,18S,19S,E)-8-ISOBUTYL-18-((5S,6S)-6-METHOXY-3,5-DIMETHYL-7-PHENYLHEPTYL)-1,2,5,12,15,19-HEXAMETHYL-3,6,9,13,16,20,25-HEPTAOXO-1,4,7,10,14,17,21-HEPTAAZACYCLOPENTACOS-21-ENE-11,22-DICARBOXYLIC ACID
- Motuporin
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GLRA2 and BAG6 |
glycine receptor, alpha 2 |
BCL2-associated athanogene 6 |
- Ion channel transport
- Ligand-gated ion channel transport
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- Glycine
- Lindane
- Picrotoxin
- Ethanol
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GRIN2D and TRAF3 |
glutamate receptor, ionotropic, N-methyl D-aspartate 2D |
TNF receptor-associated factor 3 |
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- CREB phosphorylation through the activation of CaMKII
- CREB phosphorylation through the activation of Ras
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Unblocking of NMDA receptor, glutamate binding and activation
- Ras activation uopn Ca2+ infux through NMDA receptor
- Post NMDA receptor activation events
- Transmission across Chemical Synapses
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- Activated TLR4 signalling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- TRAF3-dependent IRF activation pathway
- Toll-Like Receptors Cascades
- Negative regulators of RIG-I/MDA5 signaling
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- MyD88-independent cascade
- Innate Immune System
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
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- L-Glutamic Acid
- Meperidine
- Orphenadrine
- Tenocyclidine
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IL1B and IL1R2 |
interleukin 1, beta |
interleukin 1 receptor, type II |
- Signaling by Interleukins
- Interleukin-1 processing
- Interleukin-1 signaling
- Cytokine Signaling in Immune system
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- Signaling by Interleukins
- Cytokine Signaling in Immune system
- Interleukin-1 signaling
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- Minocycline
- Gallium nitrate
- Canakinumab
- Rilonacept
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LRP2 and ANKS1B |
low density lipoprotein receptor-related protein 2 |
ankyrin repeat and sterile alpha motif domain containing 1B |
- Metabolism of lipids and lipoproteins
- Visual phototransduction
- Diseases associated with visual transduction
- Metabolism of steroid hormones and vitamin D
- Vitamin D (calciferol) metabolism
- Retinoid metabolism and transport
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- Urokinase
- Insulin Regular
- Insulin, porcine
- Gentamicin
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PRKCA and NRGN |
protein kinase C, alpha |
neurogranin (protein kinase C substrate, RC3) |
- Ca-dependent events
- Signaling by GPCR
- CaM pathway
- Signaling by FGFR in disease
- Phospholipase C-mediated cascade
- Integration of energy metabolism
- Mitotic Prophase
- Signaling by Wnt
- Signaling by EGFRvIII in Cancer
- PLCG1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Regulation of KIT signaling
- Gastrin-CREB signalling pathway via PKC and MAPK
- Response to elevated platelet cytosolic Ca2+
- G alpha (z) signalling events
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Signaling by PDGF
- Calmodulin induced events
- DAP12 interactions
- Regulation of mRNA stability by proteins that bind AU-rich elements
- Opioid Signalling
- Diseases associated with visual transduction
- EGFR interacts with phospholipase C-gamma
- Signaling by ERBB2
- Signaling by EGFR
- Syndecan interactions
- GPCR downstream signaling
- Signaling by VEGF
- Calmodulin induced events
- Downstream signal transduction
- WNT5A-dependent internalization of FZD4
- Signaling by EGFR in Cancer
- Platelet activation, signaling and aggregation
- PCP/CE pathway
- Transmission across Chemical Synapses
- Trafficking of GluR2-containing AMPA receptors
- Nuclear Envelope Breakdown
- HuR stabilizes mRNA
- DAG and IP3 signaling
- M Phase
- VEGFA-VEGFR2 Pathway
- CaM pathway
- Inactivation, recovery and regulation of the phototransduction cascade
- EGFR Transactivation by Gastrin
- VEGFR2 mediated cell proliferation
- Downstream signaling of activated FGFR
- The phototransduction cascade
- Disinhibition of SNARE formation
- Innate Immune System
- Signalling by NGF
- PLC beta mediated events
- Regulation of insulin secretion
- Depolymerisation of the Nuclear Lamina
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- G-protein mediated events
- Non-integrin membrane-ECM interactions
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Trafficking of AMPA receptors
- Cell Cycle, Mitotic
- Signaling by FGFR
- beta-catenin independent WNT signaling
- Acetylcholine regulates insulin secretion
- Visual phototransduction
- Ca2+ pathway
- PLC-gamma1 signalling
- Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
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- Phosphatidylserine
- Vitamin E
- Ingenol Mebutate
- Ellagic Acid
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