ANAPC7 and FBXO5

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		ANAPC7	FBXO5
Description		anaphase promoting complex subunit 7	F-box protein 5
Image
GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Cytoskeleton Intercellular Bridge Mitotic Spindle	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Cytoskeleton Meiotic Spindle
	Molecular Function	Protein Phosphatase Binding Enzyme-substrate Adaptor Activity	Protein Binding Zinc Ion Binding Anaphase-promoting Complex Binding Protein Kinase Binding Metal Ion Binding Molecular Function Inhibitor Activity Ubiquitin Ligase Inhibitor Activity
	Biological Process	Regulation Of Mitotic Cell Cycle Brain Development Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination	Oocyte Maturation Regulation Of DNA Replication DNA Damage Response Spindle Assembly Involved In Female Meiosis I Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Cycle Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle Organization Protein Ubiquitination Negative Regulation Of DNA Endoreduplication Regulation Of Meiotic Nuclear Division Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Meiotic Nuclear Division Negative Regulation Of Mitotic Metaphase/anaphase Transition Microtubule Polymerization Spindle Assembly Cell Division Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Biomineral Tissue Development Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Mesenchymal Stem Cell Migration Negative Regulation Of Cellular Senescence
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	SCF-beta-TrCP mediated degradation of Emi1 Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Mitotic Metaphase/Anaphase Transition G1/S-Specific Transcription
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) QT interval ( 30679814) Schizophrenia ( 28991256) Total intracranial volume ( 31530798)	Body mass index ( 26426971) Chronotype ( 30696823) Morning person ( 30696823) Prostate cancer ( 23535732)
Interacting Genes		18 interacting genes: ANAPC10 ANAPC2 BUB1B CDC16 CDC20 CDC27 CDH1 CDT1 CEBPA CREBBP FBXO5 FZR1 HSPB1 OGT PTEN PTGER4 UBC UBE2S	11 interacting genes: ANAPC1 ANAPC11 ANAPC7 CDC20 CDK1 EVI5 FZR1 RAD51 SKP1 SRC TPM3
Entrez ID		51434	26271
HPRD ID		16233	09348
Ensembl ID		ENSG00000196510	ENSG00000112029
Uniprot IDs		Q4KMX6 Q9UJX3	Q9UKT4
PDB IDs		3FFL 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW	2M6N 4UI9 9GAW
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Binding Regulation Of Meiotic Cell Cycle Protein K11-linked Ubiquitination Cell Division Metaphase/anaphase Transition Of Cell Cycle Regulation Of Reproductive Process Regulation Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Regulation Of Cell Cycle Protein Branched Polyubiquitination Post-translational Protein Modification Regulation Of Chromosome Segregation Protein Ubiquitination Protein Modification Process Regulation Of Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Modification-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Phase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Spindle Regulation Of Chromosome Organization Ubiquitin Ligase Activator Activity Regulation Of Cell Cycle Phase Transition Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Cycle Process Nucleoplasm Regulation Of Nuclear Division Protein Polyubiquitination Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Intracellular Signal Transduction Regulation Of Mitotic Sister Chromatid Separation Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Separation Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Component Organization Proteolysis Regulation Of Organelle Organization Regulation Of Protein Ubiquitination Negative Regulation Of Cellular Senescence	Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Regulation Of Meiotic Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Division Regulation Of Chromosome Organization Regulation Of Sister Chromatid Segregation Proteasomal Protein Catabolic Process Post-translational Protein Modification Protein K11-linked Ubiquitination Regulation Of Chromosome Segregation Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Ubiquitin Ligase Activator Activity Proteolysis Involved In Protein Catabolic Process Regulation Of Reproductive Process Regulation Of Organelle Organization Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Metaphase/anaphase Transition Protein Branched Polyubiquitination Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Mitotic Cell Cycle Phase Transition Protein K48-linked Ubiquitination Protein Polyubiquitination Positive Regulation Of Cell Cycle Phase Transition Protein Modification Process Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Cell Cycle Positive Regulation Of Mitotic Cell Cycle DNA Synthesis Involved In Mitotic DNA Replication Positive Regulation Of Chromosome Separation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Protein Modification By Small Protein Conjugation Proteolysis Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Cytosol Positive Regulation Of Mitotic Nuclear Division Thymidine Biosynthetic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Thymidine Metabolic Process Cytoskeleton Positive Regulation Of Organelle Organization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?