ANAPC7

Gene Name		anaphase promoting complex subunit 7
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Protein Phosphatase Binding
	Biological Process	Mitotic Cell Cycle Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K11-linked Ubiquitination
Pathways		Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		14 interactors: ANAPC10 ANAPC2 ANAPC4 BUB1B CDC16 CDC20 CDC27 CDH1 CDT1 CREBBP FBXO5 FZR1 UBC UBE2S
Entrez ID		51434
HPRD ID		16233
Ensembl ID		ENSG00000196510
Uniprot IDs		Q4KMX6 Q69YV3 Q9UJX3
PDB IDs		3FFL
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Negative Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Cell Cycle Checkpoint Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Mitotic Cell Cycle Process Negative Regulation Of Transferase Activity Regulation Of Mitotic Sister Chromatid Separation Mitotic Cell Cycle Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Protein Catabolic Process Regulation Of Cell Division Cell Division Negative Regulation Of Cellular Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Cell Cycle Process Spindle Assembly Checkpoint Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Mitotic Spindle Checkpoint Positive Regulation Of Proteolysis Protein Polyubiquitination Negative Regulation Of Chromosome Segregation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Cellular Macromolecule Catabolic Process
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