ANAPC7 and CDT1

Number of citations of the paper that reports this interaction (PMID 18162579)
19

Data Source:
BioGRID (pull down)

		ANAPC7	CDT1
Gene Name		anaphase promoting complex subunit 7	chromatin licensing and DNA replication factor 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Phosphatase Binding	DNA Binding Protein Binding
	Biological Process	Mitotic Cell Cycle Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K11-linked Ubiquitination	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Regulation Of DNA-dependent DNA Replication Initiation Regulation Of Nuclear Cell Cycle DNA Replication
Pathways		Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System	E2F mediated regulation of DNA replication Synthesis of DNA Activation of the pre-replicative complex DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition Activation of the pre-replicative complex S Phase Orc1 removal from chromatin Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition G1/S-Specific Transcription Removal of licensing factors from origins CDT1 association with the CDC6:ORC:origin complex Association of licensing factors with the pre-replicative complex Mitotic G1-G1/S phases Switching of origins to a post-replicative state
Drugs
Diseases
GWAS			mean corpuscular hemoglobin concentration ( 20139978)
Protein-Protein Interactions		14 interactors: ANAPC10 ANAPC2 ANAPC4 BUB1B CDC16 CDC20 CDC27 CDH1 CDT1 CREBBP FBXO5 FZR1 UBC UBE2S	29 interactors: ANAPC7 BAZ1B CCNA2 CCNB1 CDC20 CDC23 CDC5L CDC6 CDK1 CDK2 DDB1 DTL EP300 FBXO31 FOXO3 FZR1 GMNN KAT2B MAPK1 MCM4 MCM6 MCM7 NPM1 ORC1 ORC2 PCNA SKP2 SMARCA5 UBB
Entrez ID		51434	81620
HPRD ID		16233	06900
Ensembl ID		ENSG00000196510	ENSG00000167513
Uniprot IDs		Q4KMX6 Q69YV3 Q9UJX3	Q9H211
PDB IDs		3FFL	2LE8 2WVR
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Negative Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Cell Cycle Checkpoint Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Mitotic Cell Cycle Process Negative Regulation Of Transferase Activity Regulation Of Mitotic Sister Chromatid Separation Mitotic Cell Cycle Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Protein Catabolic Process Regulation Of Cell Division Cell Division Negative Regulation Of Cellular Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Cell Cycle Process Spindle Assembly Checkpoint Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Mitotic Spindle Checkpoint Positive Regulation Of Proteolysis Protein Polyubiquitination Negative Regulation Of Chromosome Segregation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Cellular Macromolecule Catabolic Process	Cell Cycle Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cell Cycle Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Cellular Response To Stress Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process DNA Replication Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Mitotic Cell Cycle Cellular Protein Catabolic Process Chromosome Organization Positive Regulation Of Ubiquitin-protein Transferase Activity Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process DNA Repair Nucleobase-containing Compound Metabolic Process Mitotic Nuclear Division Regulation Of Protein Ubiquitination G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Organelle Organization Cellular Macromolecule Catabolic Process Heterocycle Metabolic Process Negative Regulation Of Mitotic Cell Cycle Cellular Aromatic Compound Metabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process
Tagcloud ?			assembled assembling cdc6 creates double generates head helicase heptamer hexamer hexamers hydrolysis interlocked intermediates juxtaposition license licensing loaded loaders mcm2 minichromosome misaligned multisubunit orc origins prereplication recruit replication replicative
Tagcloud (Difference) ?			assembled assembling cdc6 creates double generates head helicase heptamer hexamer hexamers hydrolysis interlocked intermediates juxtaposition license licensing loaded loaders mcm2 minichromosome misaligned multisubunit orc origins prereplication recruit replication replicative
Tagcloud (Intersection) ?