CDK8 and FLT3

		CDK8	FLT3
Description		cyclin dependent kinase 8	fms related receptor tyrosine kinase 3
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Nucleolus Mediator Complex Protein-containing Complex CKM Complex	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Plasma Membrane Endosome Membrane Membrane Protein-containing Complex Receptor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Vascular Endothelial Growth Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Nuclear Glucocorticoid Receptor Binding Protein-containing Complex Binding Phosphatidylinositol 3-kinase Activator Activity
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle	Leukocyte Homeostasis Myeloid Progenitor Cell Differentiation Pro-B Cell Differentiation Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Cell Migration Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis B Cell Differentiation Common Myeloid Progenitor Cell Proliferation Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Lymphocyte Proliferation Protein Autophosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Cytokine Stimulus Cellular Response To Glucocorticoid Stimulus Dendritic Cell Differentiation Liver Regeneration
Pathways		PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Generic Transcription Pathway SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	PI3K Cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling FLT3 Signaling FLT3 Signaling STAT5 Activation FLT3 mutants bind TKIs STAT5 activation downstream of FLT3 ITD mutants KW2449-resistant FLT3 mutants semaxanib-resistant FLT3 mutants crenolanib-resistant FLT3 mutants gilteritinib-resistant FLT3 mutants lestaurtinib-resistant FLT3 mutants midostaurin-resistant FLT3 mutants pexidartinib-resistant FLT3 mutants ponatinib-resistant FLT3 mutants quizartinib-resistant FLT3 mutants sorafenib-resistant FLT3 mutants sunitinib-resistant FLT3 mutants tandutinib-resistant FLT3 mutants linifanib-resistant FLT3 mutants tamatinib-resistant FLT3 mutants Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants Negative regulation of FLT3 FLT3 signaling through SRC family kinases FLT3 signaling through SRC family kinases FLT3 signaling by CBL mutants
Drugs		Alvocidib	Sorafenib Sunitinib XL999 Tandutinib Linifanib Lestaurtinib Midostaurin Ponatinib Nintedanib Pacritinib Tivozanib Fostamatinib Gilteritinib Brigatinib Fedratinib Amuvatinib Quizartinib Pexidartinib Pralsetinib
Diseases			Acute myeloid leukemia (AML)
GWAS		Immune response to measles-mumps-rubella vaccine ( 24811271) Sporadic pituitary adenoma ( 26029870)	Apolipoprotein A1 levels ( 32203549) Autoimmune thyroid disease ( 32581359) Basophil count ( 32888494) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Pancreatic cancer ( 25086665) Plateletcrit ( 32888494) Psoriasis ( 25854761) Rapid automised naming of digits ( 30741946) Serum total protein levels ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Tourette syndrome ( 30818990) White blood cell count ( 27863252 32888494) White blood cell count (monocyte) ( 28158719)
Interacting Genes		39 interacting genes: AURKA BCL6 BMPR1A BUB1 CCNC CCND1 CCNH CDH1 CDKN2B CEBPA CTDP1 ERBB2 ERCC3 ESR1 ESR2 H3C14 KRAS MAML1 MBP MCC MED12 MED21 MED25 MED26 MED8 MED9 MLH3 MYC NRIP1 POLR2A PRMT5 SMAD2 SMAD3 SMARCA4 SREBF1 SUZ12 TOP1 TP53 WDR77	18 interacting genes: CBL CBLB CTNNB1 ERBB2 FIZ1 FLT3LG GRB2 IKBKG INPP5D NCK1 PTPN11 PTPN12 PTPN6 SH3BP2 SLA SOCS1 SRC UBE2L6
Entrez ID		1024	2322
HPRD ID		04422	00635
Ensembl ID		ENSG00000132964	ENSG00000122025
Uniprot IDs		P49336	P36888
PDB IDs		3RGF 4CRL 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L 5BNJ 5CEI 5FGK 5HBE 5HBH 5HBJ 5HNB 5HVY 5I5Z 5ICP 5IDN 5IDP 5XQX 5XS2 6QTG 6QTJ 6R3S 6T41 6TPA 6Y0A 8TQ2 8TQC 8TQW 9H8C 9H8S	1RJB 3QS7 3QS9 4RT7 4XUF 5X02 6IL3 6JQR 7QDP 7ZV9 8XB1
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Initiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Mediator Complex Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Differentiation Nucleus Chromatin Binding Transcription Preinitiation Complex Assembly Negative Regulation Of Developmental Process Regulation Of MiRNA Transcription Cell Population Proliferation Animal Organ Development Regulation Of MiRNA Metabolic Process RNA Polymerase II Preinitiation Complex Assembly DNA-templated Transcription Animal Organ Regeneration Positive Regulation Of MiRNA Transcription Core Mediator Complex Liver Development Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Regulation Of Cell Population Proliferation Gland Development Protein-DNA Complex Assembly Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Cell Differentiation	Phosphotyrosine Residue Binding Receptor Tyrosine Kinase Binding Regulation Of Lymphocyte Activation Ephrin Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Activation ERBB Signaling Pathway Negative Regulation Of Immune System Process Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Activation Regulation Of Leukocyte Proliferation Cellular Response To Growth Factor Stimulus SH3 Domain Binding Response To Growth Factor Negative Regulation Of Leukocyte Activation Regulation Of MAPK Cascade Positive Regulation Of Lymphocyte Activation Negative Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Leukocyte Activation Positive Regulation Of Cell Activation Immune System Process Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Neutrophil Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Lymphocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Cell Activation Regulation Of T Cell Proliferation Negative Regulation Of Leukocyte Proliferation Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Neutrophil Activation T Cell Receptor Signaling Pathway T Cell Costimulation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Neutrophil Activation Involved In Immune Response Immune Response-activating Signaling Pathway Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Regulation Of Cell Adhesion
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