CDK8 and SUZ12

Number of citations of the paper that reports this interaction (PMID 22668559)
1

Data Source:
BioGRID (pull down, pull down)

		CDK8	SUZ12
Gene Name		cyclin-dependent kinase 8	SUZ12 polycomb repressive complex 2 subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mediator Complex	Sex Chromatin Nucleus Nucleoplasm Nucleolus ESC/E(Z) Complex
	Molecular Function	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity	Chromatin Binding RNA Binding Protein Binding Methylated Histone Binding Histone Methyltransferase Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Cell Proliferation Gene Expression Histone Methylation Histone Ubiquitination Regulation Of Gene Expression, Epigenetic Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic
Pathways		Loss of Function of TGFBR2 in Cancer PPARA activates gene expression Signaling by NOTCH1 HD Domain Mutants in Cancer Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer Fatty acid, triacylglycerol, and ketone body metabolism SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer NOTCH1 Intracellular Domain Regulates Transcription Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Constitutive Signaling by NOTCH1 PEST Domain Mutants SMAD4 MH2 Domain Mutants in Cancer	Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		29 interactors: BCL6 CCNC CCNH CDKN2B CTD CTDP1 ERCC3 ESR1 ESR2 HIST2H3C MAML1 MBP MED12 MED21 MED25 MED26 MED8 MED9 MYC NRIP1 POLR2A SGCG SMAD2 SMAD3 SMARCA4 SREBF1 SUZ12 TOP1 TP53	15 interactors: AEBP2 CDK19 CDK8 CREB1 CTCF EZH2 HIST1H1A HIST3H3 MED17 MED6 PAXIP1 PJA1 UBE2I USP7 WDR77
Entrez ID		1024	23512
HPRD ID		04422	06949
Ensembl ID		ENSG00000132964	ENSG00000178691
Uniprot IDs		P49336	A8K1U9 J3QQW9 Q15022
PDB IDs		3RGF 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Viral Transcription Regulation Of Gene Expression, Epigenetic Regulation Of Cell Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Viral Transcription Positive Regulation Of Viral Process Negative Regulation Of Gene Expression, Epigenetic Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Organ Development	Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Chromatin Organization Organelle Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Maintenance Of DNA Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Modification Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Gene Expression Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cellular Protein Modification Process Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Metabolic Process DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Regulation Of Histone Acetylation Positive Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Regulation Of Histone Methylation Cellular Macromolecule Biosynthetic Process DNA Methylation Positive Regulation Of Histone H3-K36 Methylation Positive Regulation Of SUMO Transferase Activity Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process
Tagcloud ?		absent acetyltransferase acetyltransferases cbp chromatography competent complex contains conventional directed elongation form histone homolog ii importantly interacts nonphosphorylated notably pcaf polymerase purified remodeling rna snf srb srb10 swi yeast	arise border cartilage cooperates craniofacial crest differentiate ectoderm eed embryogenesis expand extensively ezh2 fails h3k27 learnt migrate neural occupancy plate polycomb prc2 repressive slug snail2 specification trimethylation vertebrate xenopus
Tagcloud (Difference) ?		absent acetyltransferase acetyltransferases cbp chromatography competent complex contains conventional directed elongation form histone homolog ii importantly interacts nonphosphorylated notably pcaf polymerase purified remodeling rna snf srb srb10 swi yeast	arise border cartilage cooperates craniofacial crest differentiate ectoderm eed embryogenesis expand extensively ezh2 fails h3k27 learnt migrate neural occupancy plate polycomb prc2 repressive slug snail2 specification trimethylation vertebrate xenopus
Tagcloud (Intersection) ?