FGFBP1 and HSPG2

Number of citations of the paper that reports this interaction (PMID 11148217)
21

Data Source:
HPRD (in vivo, two hybrid)

		FGFBP1	HSPG2
Gene Name		fibroblast growth factor binding protein 1	heparan sulfate proteoglycan 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface	Extracellular Region Basal Lamina Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Extracellular Matrix Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Heparin Binding Fibroblast Growth Factor Binding	Protein Binding Protein C-terminus Binding Metal Ion Binding
	Biological Process	Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway	Retinoid Metabolic Process Angiogenesis Endochondral Ossification Chondrocyte Differentiation Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Brain Development Phototransduction, Visible Light Protein Localization Pathogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Lipoprotein Metabolic Process Small Molecule Metabolic Process Embryonic Skeletal System Morphogenesis Cardiac Muscle Tissue Development Cartilage Development Involved In Endochondral Bone Morphogenesis
Pathways			Lipoprotein metabolism Metabolism of lipids and lipoproteins MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Degradation of the extracellular matrix Amyloids Defective CHST14 causes EDS, musculocontractural type Laminin interactions Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Glycogen storage diseases Defective CHST6 causes MCDC1 Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 Diseases associated with visual transduction MPS IV - Morquio syndrome A Integrin cell surface interactions Metabolism of carbohydrates HS-GAG biosynthesis MPS VI - Maroteaux-Lamy syndrome MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type Chylomicron-mediated lipid transport Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Lipid digestion, mobilization, and transport Non-integrin membrane-ECM interactions Defective EXT1 causes exostoses 1, TRPS2 and CHDS Visual phototransduction Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome HS-GAG degradation
Drugs			Palifermin
Diseases
GWAS
Protein-Protein Interactions		5 interactors: FGF1 FGF2 FIBP HSPG2 UBQLN4	29 interactors: APP ATF7IP ATN1 BMP1 CACNA1A COL13A1 CTGF ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN ITGA2 ITGB1 LAMA1 NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TTR VWA1
Entrez ID		9982	3339
HPRD ID		06371	00804
Ensembl ID		ENSG00000137440	ENSG00000142798
Uniprot IDs		Q14512	P98160
PDB IDs			3SH4 3SH5
Enriched GO Terms of Interacting Partners?		Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Angiogenesis Glycosaminoglycan Catabolic Process Blood Vessel Morphogenesis Branching Involved In Ureteric Bud Morphogenesis Ureteric Bud Morphogenesis Blood Vessel Development Vasculature Development Nephron Morphogenesis Renal Tubule Morphogenesis Cellular Response To Growth Factor Stimulus Response To Growth Factor Renal Tubule Development Kidney Morphogenesis Regulation Of Endothelial Cell Migration Branch Elongation Involved In Ureteric Bud Branching Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Angiogenesis Positive Regulation Of ERK1 And ERK2 Cascade Mesonephros Development Positive Regulation Of Cell Division Phosphatidylinositol-mediated Signaling Regulation Of Chemotaxis Nephron Development Regulation Of Epithelial Cell Migration Insulin Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Kidney Epithelium Development Epidermal Growth Factor Receptor Signaling Pathway Cardiovascular System Development ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Glycosaminoglycan Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Regulation Of Behavior Regulation Of ERK1 And ERK2 Cascade Cartilage Development Organ Morphogenesis Branching Morphogenesis Of An Epithelial Tube Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of MAP Kinase Activity	Extracellular Matrix Organization Extracellular Structure Organization Multicellular Organismal Development Cell-matrix Adhesion System Development Developmental Process Anatomical Structure Development Cell-substrate Adhesion Response To Wounding Organ Development Locomotion Regulation Of Cell Migration Positive Regulation Of Cell Proliferation Platelet Degranulation Blood Vessel Morphogenesis Regulation Of Cell Motility Cardiovascular System Development Positive Regulation Of Epithelial Cell Migration Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Extracellular Matrix Disassembly Positive Regulation Of Cell Motility Blood Vessel Development Secretion By Cell Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Vasculature Development Anatomical Structure Morphogenesis Response To Growth Factor Wound Healing Positive Regulation Of Cellular Protein Metabolic Process Chemotaxis Regulation Of Cell Proliferation Blood Coagulation Secretion Hemostasis Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Epithelial Cell Proliferation Regulation Of Cellular Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol Biosynthetic Process Organ Morphogenesis Angiogenesis Tissue Development Exocytosis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor
Tagcloud ?		3kda centrifugal ddr1 detailing ectodomains gaining gpa33 identifications intramembrane ionscore lim1215 lim1863 macc1 mascot merops mspro nanolc percolator plxdc2 rip salient sanger secretome secretopeptidome smagp thresholding tumourigenesis ultrafiltration utilised	akathisia bradykinesia drd3 drd4 dyskinesia dystonia fluctuating grin2a grin2b htr2c naturalistic nominal orofacial parkinsonism preferably rater rs10772715 rs11644461 rs11866328 rs1345423 rs1650420 rs2192970 rs324035 rs4911871 rs7192557 tardive td tremor truncal
Tagcloud (Difference) ?		3kda centrifugal ddr1 detailing ectodomains gaining gpa33 identifications intramembrane ionscore lim1215 lim1863 macc1 mascot merops mspro nanolc percolator plxdc2 rip salient sanger secretome secretopeptidome smagp thresholding tumourigenesis ultrafiltration utilised	akathisia bradykinesia drd3 drd4 dyskinesia dystonia fluctuating grin2a grin2b htr2c naturalistic nominal orofacial parkinsonism preferably rater rs10772715 rs11644461 rs11866328 rs1345423 rs1650420 rs2192970 rs324035 rs4911871 rs7192557 tardive td tremor truncal
Tagcloud (Intersection) ?