FGFBP1 and ASPH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FGFBP1	ASPH
Description		fibroblast growth factor binding protein 1	aspartate beta-hydroxylase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Calcium Channel Complex
	Molecular Function	Protein Binding Heparin Binding Fibroblast Growth Factor Binding Growth Factor Binding	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Electron Transfer Activity Oxidoreductase Activity Transmembrane Transporter Binding Metal Ion Binding Dioxygenase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity
	Biological Process	Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Myoblast Proliferation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Myoblast Proliferation	Detection Of Calcium Ion Muscle Contraction Pattern Specification Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Stability Activation Of Store-operated Calcium Channel Activity Response To ATP Limb Morphogenesis Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Homeostasis Roof Of Mouth Development Face Morphogenesis Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Depolymerization
Pathways		FGFR2b ligand binding and activation	Stimuli-sensing channels Ion homeostasis Protein hydroxylation
Drugs			Aspartic acid
Diseases
GWAS		Severe insulin-deficient type 2 diabetes ( 34737425)	Blood protein levels ( 30072576) BRCA1/2-negative high-risk breast cancer ( 30323354) Resting heart rate ( 28270201) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592) Urate levels in overweight individuals ( 25811787)
Interacting Genes		7 interacting genes: ANXA1 ASPH FGF1 FGF2 FIBP HSPG2 UBQLN4	73 interacting genes: - AGR2 APP BGLAP CDSN CHRM5 CST1 CTSA CXorf66 DCD DEFB1 DHRSX ENPP6 FBXO7 FDCSP FGFBP1 FKBP7 GAL GAST GET3 GOLM1 GPR119 GPX7 GPX8 GSC2 GUCA2A IL21 INSL5 KCNIP1 KCNIP3 KCNIP4 LCN2 LINC00632 LRPAP1 LTA NUCB2 OCIAD1 OGT PCSK4 PDGFA PDGFRL PLAAT2 PLEKHF2 PRAP1 PRB1 PRB2 PRB4 PRH1 PTH PTN RCN1 RELL2 RNASEH1 SCGB1C2 SDC2 SF3A2 SGTB SHISAL1 SLC51B SMIM11 SMIM19 SOD3 SPINK1 TMEM167B TMX2 TNFRSF10B TRDN TUFM TXNDC15 UGT2B11 WFDC12 WFDC5 ZG16
Entrez ID		9982	444
HPRD ID		06371	08996
Ensembl ID		ENSG00000137440	ENSG00000198363
Uniprot IDs		Q14512	B4DQ07 B7ZM96 G3XAN5 Q12797
PDB IDs			5APA 5JQY 5JTC 5JZ6 5JZ8 5JZA 5JZU 6Q9F 6Q9I 6QA5 6RK9 6YYU 6YYV 6YYW 6YYX 6YYY 6Z6Q 6Z6R 7BMI 7BMJ 7E6J 7YB8 7YB9 7YBA 7YBB 7YBC 8RE5 8RE6 8RE7 8RE8 8RE9
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Endothelial Cell Migration Integrin Binding Regulation Of Endothelial Cell Migration Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Epithelial Cell Proliferation Organ Induction Fibroblast Growth Factor Receptor Binding Positive Regulation Of Sprouting Angiogenesis Regulation Of Animal Organ Formation Developmental Induction Positive Regulation Of MAP Kinase Activity Regulation Of Protein Metabolic Process Branching Involved In Ureteric Bud Morphogenesis Regulation Of Cell Population Proliferation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Cell Population Proliferation Regulation Of Anatomical Structure Morphogenesis Regulation Of Vasculature Development Regulation Of Angiogenesis Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Sprouting Angiogenesis Angiogenesis Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of MAP Kinase Activity Regulation Of Morphogenesis Of An Epithelium Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Wound Healing Branch Elongation Involved In Ureteric Bud Branching Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Extracellular Matrix Regulation Of Animal Organ Morphogenesis Positive Regulation Of Cell Division Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Endothelial Cell Proliferation Epidermal Cell Differentiation Peptidyl-aspartic Acid 3-dioxygenase Activity Lung Development Response To Wortmannin Positive Regulation Of Inner Ear Receptor Cell Differentiation Positive Regulation Of Cell Fate Specification Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Collagen V Binding Nuclear Proteasome Complex Neurogenesis Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Migration	Extracellular Region Golgi Lumen Extracellular Space Endoplasmic Reticulum Lumen Hormone Activity Defense Response To Bacterium Response To Bacterium Endoplasmic Reticulum Antibacterial Humoral Response Defense Response To Gram-positive Bacterium Regulation Of Metal Ion Transport Peptidase Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport
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