CDKN3 and PPP1R12A

Number of citations of the paper that reports this interaction (PubMedID 24704824)
0

Data Source:
BioGRID (enzymatic study)

		CDKN3	PPP1R12A
Description		cyclin dependent kinase inhibitor 3	protein phosphatase 1 regulatory subunit 12A
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Kinetochore Stress Fiber Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc A Band Contractile Muscle Fiber PTW/PP1 Phosphatase Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity	Enzyme Inhibitor Activity Protein Binding Myosin Phosphatase Regulator Activity Phosphatase Regulator Activity Protein Kinase Binding 14-3-3 Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Population Proliferation Regulation Of Cell Cycle	Mitotic Cell Cycle Protein Dephosphorylation Centrosome Cycle Signal Transduction Regulation Of Cell Adhesion Negative Regulation Of Catalytic Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleocytoplasmic Transport Neuron Projection Morphogenesis Cellular Response To Xenobiotic Stimulus Regulation Of Establishment Of Endothelial Barrier
Pathways			Regulation of PLK1 Activity at G2/M Transition RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs
Diseases
GWAS		Cortical volume ( 32963231) Dental caries ( 23259602) Endometrial cancer (Non-endometrioid histology) ( 30093612) High myopia ( 31816047) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) Monobrow thickness ( 26926045) Myopia ( 27182965) Refractive error ( 32231278) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)	Platelet count ( 32888494) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		9 interacting genes: CDC25A CDK1 CDK2 CDK3 CEBPA MS4A3 NCOA3 PPP1R12A ROCK2	18 interacting genes: CDK1 CDKN3 CHEK1 CHEK2 DMPK IL16 ILK KDM1A MPRIP PLK1 PPP1CB PRKG1 RHOA ROCK1 ROCK2 SETD7 USP7 YWHAG
Entrez ID		1033	4659
HPRD ID		00450	03606
Ensembl ID		ENSG00000100526	ENSG00000058272
Uniprot IDs		G3V2J7 Q16667	B2RAH5 O14974
PDB IDs		1FPZ 1FQ1	2KJY 5HUZ
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle G2/M Phase Transition Cyclin Binding Mitotic Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Activity Cell Cycle Phase Transition Positive Regulation Of DNA Replication Cyclin-dependent Protein Kinase Holoenzyme Complex G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Histone Kinase Activity Regulation Of Cell Cycle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule Organizing Center Organization Mitotic Nuclear Membrane Disassembly Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Regulation Of DNA Replication Nuclear Membrane Disassembly Membrane Disassembly Protein Serine/threonine Kinase Activity Regulation Of Establishment Of Endothelial Barrier Centrosome Duplication Regulation Of Cell Cycle Phase Transition Cell Division Nuclear Envelope Organization Regulation Of Epithelial Cell Differentiation Regulation Of Mitotic Cell Cycle Protein Kinase Activity Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Macromolecule Metabolic Process Regulation Of Keratinocyte Differentiation Kinase Activity Regulation Of Endothelial Cell Differentiation Centrosome Positive Regulation Of Cell Cycle Process Centrosome Cycle Nuclear Membrane Organization Positive Regulation Of Metabolic Process Cell Population Proliferation Positive Regulation Of DNA Metabolic Process Regulation Of Multicellular Organismal Development Regulation Of Epidermal Cell Differentiation Pronuclear Fusion Cellular Response To Xenobiotic Stimulus	Protein Serine/threonine Kinase Activity Protein Modification Process Intracellular Signal Transduction Protein Phosphorylation Protein Kinase Activity Protein Serine Kinase Activity Phosphorylation Kinase Activity Regulation Of Circadian Rhythm Mitotic Nuclear Membrane Disassembly Microtubule Cytoskeleton Organization Involved In Mitosis G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Protein Metabolic Process Mitotic Cell Cycle Phase Transition Nuclear Membrane Disassembly Membrane Disassembly Cell Cycle Phase Transition Mitotic Cytokinesis Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Chromosome, Telomeric Region Intracellular Signaling Cassette Rho-dependent Protein Serine/threonine Kinase Activity Nuclear Envelope Organization Nucleotide Binding Cytoskeleton-dependent Cytokinesis Mitotic Spindle Organization Focal Adhesion Regulation Of Metabolic Process Cytoskeleton Organization Phosphate-containing Compound Metabolic Process DNA Damage Checkpoint Signaling Signal Transduction ATP Binding Regulation Of Muscle System Process Positive Regulation Of Cell Cycle Process Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Metabolic Process Regulation Of DNA Metabolic Process Cytosol Regulation Of Cell Adhesion Regulation Of Macromolecule Metabolic Process Regulation Of Angiotensin-activated Signaling Pathway Negative Regulation Of Bicellular Tight Junction Assembly Regulation Of Organelle Organization Regulation Of Cellular Response To Stress Regulation Of Gene Expression Blood Vessel Diameter Maintenance
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