PAN2 and RBBP8

Number of citations of the paper that reports this interaction (PubMedID 33097710)
55

Data Source:
BioGRID (enzymatic study)

		PAN2	RBBP8
Description		poly(A) specific ribonuclease subunit PAN2	RB binding protein 8, endonuclease
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol PAN Complex	Nucleus Nucleoplasm Chromosome Transcription Repressor Complex Site Of Double-strand Break BRCA1-C Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding Nuclease Activity Exonuclease Activity Poly(A)-specific Ribonuclease Activity Cysteine-type Deubiquitinase Activity Protein Binding Hydrolase Activity Metal Ion Binding	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding Damaged DNA Binding Transcription Corepressor Activity Nuclease Activity Endonuclease Activity Protein Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Processing Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Blastocyst Hatching DNA Repair DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Homologous Recombination Mitotic G2/M Transition Checkpoint Negative Regulation Of DNA-templated Transcription Cell Division Meiotic Cell Cycle DNA Strand Resection Involved In Replication Fork Processing
Pathways		Deadenylation of mRNA	HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Transcriptional Regulation by E2F6 Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases			Seckel syndrome
GWAS		Axial length ( 24144296) Height ( 25429064 34054925 34270706) Refractive error ( 32231278)	Eosinophil percentage of white cells ( 27863252) Estradiol levels ( 34255042) Height ( 18391951 25429064) Hip circumference adjusted for BMI ( 34021172) Intracranial aneurysm ( 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Late-onset myasthenia gravis ( 26562150) Lung function (FEV1) ( 30061609) Lymphocyte count ( 32888494) Scalp hair shape ( 26926045) Tuberculosis ( 20694014) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		9 interacting genes: ATM DYNLL1 PABPC1 PAN3 RBBP8 RBCK1 RNF144B TNRC6A TRIM35	40 interacting genes: ATM BARD1 BRCA1 CLU CTBP1 CUL3 DNA2 FXR2 FZR1 HID1 IGFBP7 IKBKG IKZF1 IKZF3 KLHL15 LIMS1 LMO1 LMO2 LMO4 MAP2K4 NTAQ1 PAN2 PCNA PELI2 PIAS4 PIN1 PRRG4 RAF1 RB1 RBL1 RBL2 RGS17 RNF4 SIAH1 SIAH2 TGIF2 TMEM54 TOPBP1 UBE2I USP4
Entrez ID		9924	5932
HPRD ID		15640	04990
Ensembl ID		ENSG00000135473	ENSG00000101773
Uniprot IDs		Q504Q3	Q99708
PDB IDs			1Y98 2L4Z 4D2H 7BGF
Enriched GO Terms of Interacting Partners?		DNA Strand Resection Involved In Replication Fork Processing Site Of Double-strand Break Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Poly(A) Binding DNA Double-strand Break Processing Macromolecule Catabolic Process Positive Regulation Of Catabolic Process RNA Catabolic Process Protein Ubiquitination Homologous Recombination Negative Regulation Of Mitotic Cell Cycle Protein Modification By Small Protein Conjugation Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Mitotic G2/M Transition Checkpoint Nucleobase-containing Compound Catabolic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Post-translational Protein Modification Negative Regulation Of Cell Cycle Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Ubiquitin Protein Ligase Activity Regulation Of MRNA Metabolic Process Apoptotic Process Establishment Of RNA Localization To Telomere Negative Regulation Of Metabolic Process Establishment Of Protein-containing Complex Localization To Telomere Programmed Cell Death Positive Regulation Of Telomerase Catalytic Core Complex Assembly Cell Death Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing PAN Complex Positive Regulation Of Organelle Assembly Positive Regulation Of RNA Metabolic Process P-body Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity Catabolic Process Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Gene Expression Response To Stress	Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Mitotic Cell Cycle Post-translational Protein Modification Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Protein Modification Process BRCA1-B Complex Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Mitotic G2/M Transition Checkpoint Negative Regulation Of Biosynthetic Process Regulation Of Mitotic Cell Cycle Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Protein Ubiquitination Mitotic G2 DNA Damage Checkpoint Signaling Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Metabolic Process Homologous Recombination Nucleoplasm Regulation Of Apoptotic Signaling Pathway Protein Polyubiquitination DNA Strand Resection Involved In Replication Fork Processing
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