PAN2 and TRIM35

Number of citations of the paper that reports this interaction (PMID 23105109)
4

Data Source:
BioGRID (two hybrid)

		PAN2	TRIM35
Gene Name		PAN2 poly(A) specific ribonuclease subunit	tripartite motif containing 35
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus Cytosol PAN Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	3'-5'-exoribonuclease Activity Nucleic Acid Binding Poly(A)-specific Ribonuclease Activity Protein Binding	Molecular_function Zinc Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Gene Expression RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Apoptotic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Viral Release From Host Cell
Pathways		Deadenylation of mRNA Deadenylation-dependent mRNA decay	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: DYNLL1 PABPC1 PAN3 RBCK1 RNF144B TNRC6A TRIM35	13 interactors: PAN2 TRIM11 TRIM5 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2K UBE2U UBE2W USP2 USP49
Entrez ID		9924	23087
HPRD ID		15640	15553
Ensembl ID		ENSG00000135473	ENSG00000104228
Uniprot IDs		Q504Q3	E5RGB3 Q9UPQ4
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Poly(A) Tail Shortening Cellular Macromolecule Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Silencing By RNA MRNA 3'-end Processing Gene Silencing RNA 3'-end Processing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Nuclear-transcribed MRNA Catabolic Process Protein Linear Polyubiquitination MRNA Catabolic Process Catabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Catabolic Process Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Positive Regulation Of Apoptotic Signaling Pathway Immune System Process Positive Regulation Of Intracellular Transport Apoptotic Process Regulation Of Cytoplasmic MRNA Processing Body Assembly Programmed Cell Death Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Cell Death Death Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Regulation Of Translation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Necroptotic Process Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Necrotic Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of MRNA 3'-end Processing Regulation Of Necroptotic Process Positive Regulation Of Organelle Organization Positive Regulation Of MRNA Catabolic Process MRNA Processing Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of Intracellular Transport Regulation Of Apoptotic Process Regulation Of Viral Release From Host Cell Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Necrotic Cell Death Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Organelle Assembly Immune Response-regulating Signaling Pathway	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process Catabolic Process Proteolysis Cellular Protein Metabolic Process Protein K11-linked Ubiquitination Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Proteasomal Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Response To Stress Cellular Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Negative Regulation Of Viral Release From Host Cell Immune Response Negative Regulation Of Viral Entry Into Host Cell Defense Response Regulation Of Protein Catabolic Process Regulation Of Viral Entry Into Host Cell Regulation Of Viral Release From Host Cell Cellular Response To Stress Immune Response-regulating Signaling Pathway Protein K63-linked Ubiquitination Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		anchoring architecture asymmetric cerevisiae deadenylase deadenylate deadenylation homodimer hydrolase imparted intertwined latches module needing nuclease onto orient pab1 pan3 pseudokinase pseudoubiquitin rnase saccharomyces shortening stoichiometry synergy tails unusual wraps	advance advantage blockade box coil coiled collectively consisting doi hcc hepatocellular isoform m2 onc oncogene online pkm2 publication pyruvate rbcc reprogramming september suppress suppresses tripartite tumorigenicity uses warburg y105
Tagcloud (Difference) ?		anchoring architecture asymmetric cerevisiae deadenylase deadenylate deadenylation homodimer hydrolase imparted intertwined latches module needing nuclease onto orient pab1 pan3 pseudokinase pseudoubiquitin rnase saccharomyces shortening stoichiometry synergy tails unusual wraps	advance advantage blockade box coil coiled collectively consisting doi hcc hepatocellular isoform m2 onc oncogene online pkm2 publication pyruvate rbcc reprogramming september suppress suppresses tripartite tumorigenicity uses warburg y105
Tagcloud (Intersection) ?