PAN2 and RNF144B

Number of citations of the paper that reports this interaction (PMID 23105109)
4

Data Source:
BioGRID (two hybrid)

		PAN2	RNF144B
Gene Name		PAN2 poly(A) specific ribonuclease subunit	ring finger protein 144B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus Cytosol PAN Complex	Ubiquitin Ligase Complex Cytoplasm Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	3'-5'-exoribonuclease Activity Nucleic Acid Binding Poly(A)-specific Ribonuclease Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Gene Expression RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Apoptotic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Deadenylation of mRNA Deadenylation-dependent mRNA decay	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Endometriosis ( 23472165)
Protein-Protein Interactions		7 interactors: DYNLL1 PABPC1 PAN3 RBCK1 RNF144B TNRC6A TRIM35	10 interactors: CDKN1A PAN2 UBE2I UBE2L3 UBE2L6 UBE2T UBE2U UBE2Z USP15 USP2
Entrez ID		9924	255488
HPRD ID		15640	17126
Ensembl ID		ENSG00000135473	ENSG00000137393
Uniprot IDs		Q504Q3	B4DZI2 Q7Z419
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Poly(A) Tail Shortening Cellular Macromolecule Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Silencing By RNA MRNA 3'-end Processing Gene Silencing RNA 3'-end Processing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Nuclear-transcribed MRNA Catabolic Process Protein Linear Polyubiquitination MRNA Catabolic Process Catabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Catabolic Process Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Positive Regulation Of Apoptotic Signaling Pathway Immune System Process Positive Regulation Of Intracellular Transport Apoptotic Process Regulation Of Cytoplasmic MRNA Processing Body Assembly Programmed Cell Death Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Cell Death Death Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Regulation Of Translation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Necroptotic Process Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Necrotic Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of MRNA 3'-end Processing Regulation Of Necroptotic Process Positive Regulation Of Organelle Organization Positive Regulation Of MRNA Catabolic Process MRNA Processing Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of Intracellular Transport Regulation Of Apoptotic Process Regulation Of Viral Release From Host Cell Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Necrotic Cell Death Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Organelle Assembly Immune Response-regulating Signaling Pathway	Cellular Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Cellular Protein Modification Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Protein Metabolic Process Protein K11-linked Ubiquitination Cellular Metabolic Process Positive Regulation Of SUMO Transferase Activity Histone H2B Conserved C-terminal Lysine Deubiquitination Regulation Of Type I Interferon Production Protein Deubiquitination Protein Modification By Small Protein Removal Positive Regulation Of Transferase Activity Cell Cycle Response To Glucocorticoid Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Intestinal Epithelial Cell Maturation Response To Corticosteroid ISG15-protein Conjugation Regulation Of Proteasomal Protein Catabolic Process Cellular Response To UV-B Protein K6-linked Ubiquitination Innate Immune Response Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Monoubiquitinated Protein Deubiquitination Locomotor Rhythm Response To Stimulus Metabolic Process Cellular Response To DNA Damage Stimulus Stress-induced Premature Senescence Cell Cycle Phase Transition Cellular Response To Organic Substance Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Arrest Response To UV-B Intestinal Epithelial Cell Development
Tagcloud ?		anchoring architecture asymmetric cerevisiae deadenylase deadenylate deadenylation homodimer hydrolase imparted intertwined latches module needing nuclease onto orient pab1 pan3 pseudokinase pseudoubiquitin rnase saccharomyces shortening stoichiometry synergy tails unusual wraps
Tagcloud (Difference) ?		anchoring architecture asymmetric cerevisiae deadenylase deadenylate deadenylation homodimer hydrolase imparted intertwined latches module needing nuclease onto orient pab1 pan3 pseudokinase pseudoubiquitin rnase saccharomyces shortening stoichiometry synergy tails unusual wraps
Tagcloud (Intersection) ?