PAN2 and PAN3

Number of citations of the paper that reports this interaction (PMID 14583602)
34

Data Source:
HPRD (in vivo, in vitro)

		PAN2	PAN3
Gene Name		PAN2 poly(A) specific ribonuclease subunit	PAN3 poly(A) specific ribonuclease subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus Cytosol PAN Complex	Cytoplasmic MRNA Processing Body Cytosol PAN Complex
	Molecular Function	3'-5'-exoribonuclease Activity Nucleic Acid Binding Poly(A)-specific Ribonuclease Activity Protein Binding	Poly(A)-specific Ribonuclease Activity Protein Binding ATP Binding Transferase Activity, Transferring Phosphorus-containing Groups Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Gene Expression RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Protein Targeting Gene Expression Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Deadenylation of mRNA Deadenylation-dependent mRNA decay	Deadenylation of mRNA Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: DYNLL1 PABPC1 PAN3 RBCK1 RNF144B TNRC6A TRIM35	3 interactors: PABPC1 PAN2 SVIL
Entrez ID		9924	255967
HPRD ID		15640	17818
Ensembl ID		ENSG00000135473	ENSG00000152520
Uniprot IDs		Q504Q3	Q58A45
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Poly(A) Tail Shortening Cellular Macromolecule Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Silencing By RNA MRNA 3'-end Processing Gene Silencing RNA 3'-end Processing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Nuclear-transcribed MRNA Catabolic Process Protein Linear Polyubiquitination MRNA Catabolic Process Catabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Catabolic Process Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Positive Regulation Of Apoptotic Signaling Pathway Immune System Process Positive Regulation Of Intracellular Transport Apoptotic Process Regulation Of Cytoplasmic MRNA Processing Body Assembly Programmed Cell Death Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Cell Death Death Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Regulation Of Translation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Necroptotic Process Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Necrotic Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of MRNA 3'-end Processing Regulation Of Necroptotic Process Positive Regulation Of Organelle Organization Positive Regulation Of MRNA Catabolic Process MRNA Processing Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of Intracellular Transport Regulation Of Apoptotic Process Regulation Of Viral Release From Host Cell Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Necrotic Cell Death Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Organelle Assembly Immune Response-regulating Signaling Pathway	Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA 3'-end Processing RNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Processing Aromatic Compound Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Metabolic Process RNA Processing Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA 3'-end Processing Positive Regulation Of MRNA Catabolic Process MRNA Stabilization MRNA Polyadenylation RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Macromolecule Catabolic Process RNA Polyadenylation Positive Regulation Of Cytokinesis Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Cytokinesis Gene Silencing By RNA Positive Regulation Of Translation Positive Regulation Of Type I Interferon Production Regulation Of MRNA Processing Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Gene Silencing Regulation Of Type I Interferon Production RNA Phosphodiester Bond Hydrolysis Positive Regulation Of Cell Division Catabolic Process Skeletal Muscle Tissue Development Osteoblast Differentiation Skeletal Muscle Organ Development
Tagcloud ?		anchoring architecture asymmetric cerevisiae deadenylase deadenylate deadenylation homodimer hydrolase imparted intertwined latches module needing nuclease onto orient pab1 pan3 pseudokinase pseudoubiquitin rnase saccharomyces shortening stoichiometry synergy tails unusual wraps	anchoring architecture asymmetric cerevisiae deadenylase deadenylate deadenylation homodimer hydrolase imparted intertwined latches module needing nuclease onto orient pab1 pan2 pseudokinase pseudoubiquitin rnase saccharomyces shortening stoichiometry synergy tails unusual wraps
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		anchoring architecture asymmetric cerevisiae deadenylase deadenylate deadenylation homodimer hydrolase imparted intertwined latches module needing nuclease onto orient pab1 pan2 pan3 pseudokinase pseudoubiquitin rnase saccharomyces shortening stoichiometry synergy tails unusual wraps