G3BP2 and USP10

Number of citations of the paper that reports this interaction (PMID 19615732)
279

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)

		G3BP2	USP10
Gene Name		GTPase activating protein (SH3 domain) binding protein 2	ubiquitin specific peptidase 10
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Early Endosome
	Molecular Function	Nucleotide Binding Receptor Signaling Complex Scaffold Activity Poly(A) RNA Binding	P53 Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Ion Channel Binding Poly(A) RNA Binding
	Biological Process	Cytoplasmic Sequestering Of NF-kappaB Ras Protein Signal Transduction MRNA Transport	DNA Repair Autophagy Regulation Of Autophagy Protein Deubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS			Height ( 18391951)
Protein-Protein Interactions		5 interactors: MDM2 NFKB1 NFKBIA PIN1 USP10	9 interactors: AR G3BP1 G3BP2 IKBKG SCNN1A SCNN1G SNX3 TP53 UBC
Entrez ID		9908	9100
HPRD ID		06570	07029
Ensembl ID		ENSG00000138757	ENSG00000103194
Uniprot IDs		Q9UN86	Q14694
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon Production Regulation Of Cellular Protein Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cholesterol Transport Cellular Response To Alkaloid Regulation Of Macrophage Derived Foam Cell Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response Toll-like Receptor 5 Signaling Pathway Defense Response Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Cellular Response To Lipid Regulation Of Lipid Storage Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Response To Peptide MyD88-dependent Toll-like Receptor Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Regulation Of Cytokine Production Signal Transduction In Response To DNA Damage Cellular Response To Growth Factor Stimulus Regulation Of Lipid Transport Response To Growth Factor Intracellular Signal Transduction Cellular Response To Organic Substance Toll-like Receptor Signaling Pathway Signal Transduction By P53 Class Mediator Cellular Response To UV-C Cellular Response To Vitamin B1 Negative Regulation Of Interleukin-12 Biosynthetic Process T Cell Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction	Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signaling Transport Sodium Ion Homeostasis Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Ras Protein Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Stimulus Regulation Of Establishment Of Protein Localization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Protein Localization Excretion Multicellular Organismal Water Homeostasis Regulation Of Wnt Signaling Pathway Toll-like Receptor 5 Signaling Pathway Positive Regulation Of Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Toll-like Receptor 10 Signaling Pathway Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Signal Transduction Involved In DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Signal Transduction Involved In Cell Cycle Checkpoint Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Apoptotic Process Toll-like Receptor 9 Signaling Pathway Negative Regulation Of Programmed Cell Death Water Homeostasis TRIF-dependent Toll-like Receptor Signaling Pathway Sensory Perception Of Taste MyD88-independent Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Death Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Localization DNA Damage Response, Signal Transduction By P53 Class Mediator
Tagcloud ?			bioinformatic class collectively crucial experiments function gain implicating inhibit initiation luciferase micrornas mir molecules noncoding oncogenic pancreatic play prediction pro progression promote roles stabilizing suggested suppressed targeting tumorigenesis ups10
Tagcloud (Difference) ?			bioinformatic class collectively crucial experiments function gain implicating inhibit initiation luciferase micrornas mir molecules noncoding oncogenic pancreatic play prediction pro progression promote roles stabilizing suggested suppressed targeting tumorigenesis ups10
Tagcloud (Intersection) ?