G3BP2 and ZNF618

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		G3BP2	ZNF618
Description		G3BP stress granule assembly factor 2	zinc finger protein 618
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoplasmic Stress Granule	Chromatin Nucleus Chromosome Pericentric Heterochromatin
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Molecular Condensate Scaffold Activity	Transcription Coregulator Binding DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Chromatin-protein Adaptor Activity
	Biological Process	Immune System Process Stress Granule Assembly Innate Immune Response MRNA Transport Protein Homooligomerization Positive Regulation Of Stress Granule Assembly	Chromatin Organization Regulation Of Transcription By RNA Polymerase II
Pathways		SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Subjective response to lithium treatment in bipolar disorder ( 26503763) Testicular germ cell tumor ( 28604728)	Adventurousness ( 30643258) Chronotype ( 30696823) Cognitive function in longevity ( 33607172) Coronary artery aneurysm in Kawasaki disease ( 27171184) Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Low density lipoprotein cholesterol levels ( 30498476) Neutrophil level response to clozapine in treatment-resistant schizophrenia ( 30647433) Pulse pressure ( 30224653 30578418) Serum metabolite concentrations in chronic kidney disease ( 29545352) Systolic blood pressure ( 30578418) Tea consumption ( 31046077)
Interacting Genes		68 interacting genes: ANXA1 CEBPA DANCR MDM2 MIR1-1 MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR128-2 MIR138-2 MIR140 MIR141 MIR145 MIR155 MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR19A MIR19B1 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR363 MIR429 MIR7-1 MIR7-2 MIR7-3 MIR92A1 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NFKB1 NFKBIA OGT PDE4B PIN1 PRMT5 RIOK1 TRIM25 USP10 ZNF618	12 interacting genes: CSNK1D CSNK1E DPPA3 G3BP2 MID1 NTAQ1 RIIAD1 TBC1D13 TPTEP2-CSNK1E UBE2I UBL5 UHRF2
Entrez ID		9908	114991
HPRD ID		06570	18719
Ensembl ID		ENSG00000138757	ENSG00000157657
Uniprot IDs		A0A7I2V3P9 A0A7I2V647 Q9UN86	Q5T7W0
PDB IDs		5DRV
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Cell Motility Regulation Of Macromolecule Metabolic Process Negative Regulation Of Locomotion Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of Cytokine Production Regulation Of Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of MRNA Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Developmental Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Angiogenesis Extracellular Space	Positive Regulation Of Non-canonical Wnt Signaling Pathway SUMO Transferase Activity Histone H3K9me2/3 Reader Activity Regulation Of Non-canonical Wnt Signaling Pathway Protein Modification Process Protein Localization To Cytoskeleton Protein Sumoylation SUMO Conjugating Enzyme Activity Protein-N-terminal Glutamine Amidohydrolase Activity Circadian Regulation Of Gene Expression Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein-N-terminal Asparagine Amidohydrolase Activity Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Circadian Rhythm Positive Regulation Of Proteasomal Protein Catabolic Process RING-like Zinc Finger Domain Binding SUMO Ligase Complex HLH Domain Binding Epigenetic Programing Of Female Pronucleus
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