SGSM2 and PNO1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SGSM2	PNO1
Gene Name		small G protein signaling modulator 2	partner of NOB1 homolog (S. cerevisiae)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Nucleolus
	Molecular Function	Rab GTPase Activator Activity Rab GTPase Binding	Poly(A) RNA Binding
	Biological Process	Positive Regulation Of Rab GTPase Activity Late Endosome To Golgi Transport
Pathways
Drugs
Diseases
GWAS		Aortic root size ( 19584346) Proinsulin levels ( 21873549)
Protein-Protein Interactions		14 interactors: AFP CA12 CELSR3 CHD3 EGFR FNBP1L GDPD2 ILF2 KHDRBS3 MPP1 PNO1 PTN RGMA RPS25	10 interactors: ATP5C1 CSNK1E FRZB GSTP1 IGFBP5 KLF6 PDPK1 RXRG SGSM2 SUPT5H
Entrez ID		9905	56902
HPRD ID		15284	14250
Ensembl ID		ENSG00000141258	ENSG00000115946
Uniprot IDs		B9A6J3 O43147	Q9NRX1
PDB IDs
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Hepatocyte Differentiation Nitric Oxide Storage Cellular Response To Organic Substance Regulation Of Signaling Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Cellular Nitrogen Compound Metabolic Process Nitric Oxide Homeostasis Negative Regulation Of Monocyte Chemotactic Protein-1 Production Skeletal Muscle Tissue Growth Late Endosome To Golgi Transport Skeletal Muscle Tissue Development Common Myeloid Progenitor Cell Proliferation Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Skeletal Muscle Organ Development Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cell Proliferation Convergent Extension Involved In Organogenesis Mammary Gland Involution Negative Regulation Of Wnt Signaling Pathway System Development Negative Regulation Of Protein Kinase Activity Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Cellular Protein Metabolic Process Tissue Development Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Kinase Activity Response To Stimulus Regulation Of Intracellular Signal Transduction Organ Development Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of JUN Kinase Activity Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Striated Muscle Cell Apoptotic Process Type B Pancreatic Cell Proliferation Wnt Signaling Pathway Muscle Organ Development Regulation Of Cellular Component Organization Regulation Of Superoxide Anion Generation
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