ORC1 and RFWD3

Number of citations of the paper that reports this interaction (PubMedID 33044890)
48

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ORC1	RFWD3
Description		origin recognition complex subunit 1	ring finger and WD repeat domain 3
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol	Nucleus Nucleoplasm Cytoplasm PML Body Site Of Double-strand Break Site Of DNA Damage
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Protein Binding ATP Binding ATP Hydrolysis Activity Metal Ion Binding	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity MDM2/MDM4 Family Protein Binding
	Biological Process	DNA Replication DNA Replication Initiation Mitotic DNA Replication Checkpoint Signaling	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Response To Ionizing Radiation Protein Ubiquitination Replication Fork Processing Mitotic G1 DNA Damage Checkpoint Signaling Interstrand Cross-link Repair Regulation Of DNA Damage Checkpoint
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS			Adult body size ( 32376654) Experiencing mood swings ( 29500382) Leukocyte telomere length ( 32109421) Multiple myeloma ( 27363682) Testicular germ cell tumor ( 23666239 28604728 28604732)
Interacting Genes		25 interacting genes: CDC45 CDC5L CDC6 CDC7 CDK2 CDT1 DBF4 GOLGA2 GOLGA6L9 H4C1 KAT7 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RB1 RFWD3 RPA2 SKP2 XPO1	17 interacting genes: APP CFTR ORC1 ORC2 PCNA RAD51 RPA1 RPA3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W
Entrez ID		4998	55159
HPRD ID		03544	07678
Ensembl ID		ENSG00000085840	ENSG00000168411
Uniprot IDs		B7Z8H0 Q13415 Q96F82	Q6PCD5
PDB IDs		5UJ7 5UJM 6P3W 7CTF 7CTG 7JPO 7JPP 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F	6CVZ
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Replication Initiation DNA Metabolic Process DNA Replication Origin Binding Regulation Of DNA Replication Regulation Of DNA-templated DNA Replication Initiation Double-strand Break Repair Via Break-induced Replication Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Nucleic Acid Metabolic Process CMG Complex Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination Nuclear Origin Of Replication Recognition Complex Recombinational Repair Nucleoplasm MCM Complex DNA Repair Double-strand Break Repair DNA Recombination Origin Recognition Complex Single-stranded DNA Binding DNA Damage Response Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Chromosome Macromolecule Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of DNA Replication Negative Regulation Of Cell Cycle Process Positive Regulation Of DNA-templated DNA Replication Nucleus Single-stranded DNA Helicase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition DNA Helicase Activity Regulation Of Primary Metabolic Process Regulation Of Nuclear Cell Cycle DNA Replication Cellular Response To Stress Helicase Activity Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling DNA Replication Preinitiation Complex Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process DNA Replication Checkpoint Signaling	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Monoubiquitination Protein Modification By Small Protein Conjugation ATP Binding DNA Metabolic Process Macromolecule Metabolic Process Post-translational Protein Modification Modification-dependent Protein Catabolic Process Nucleus Protein K11-linked Ubiquitination Nucleotide Binding Proteolysis Involved In Protein Catabolic Process DNA Replication DNA Repair Nucleoplasm Ubiquitin-dependent Protein Catabolic Process Chromosome, Telomeric Region Telomere Maintenance Macromolecule Catabolic Process Mismatch Repair DNA Damage Response Telomere Organization Proteolysis Protein Modification Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Origin Recognition Complex Male Germ Cell Nucleus Nuclear Origin Of Replication Recognition Complex TORC1 Signaling Damaged DNA Binding Negative Regulation Of TORC1 Signaling Nucleic Acid Metabolic Process Protein K63-linked Ubiquitination Cellular Response To Stress Protein-containing Complex Double-strand Break Repair DNA Replication Factor A Complex DNA Recombination TOR Signaling Chromatin Binding Lateral Element Negative Regulation Of TOR Signaling DNA Replication Origin Binding Transferase Activity Site Of Double-strand Break
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