ORC1 and MCM6

Number of citations of the paper that reports this interaction (PMID 12614612)
16

Data Source:
BioGRID (two hybrid)

		ORC1	MCM6
Gene Name		origin recognition complex, subunit 1	minichromosome maintenance complex component 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytoplasm Cytosol Plasma Membrane	Nucleus Nucleoplasm MCM Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding ATP Binding	Single-stranded DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication
Pathways		G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition G1/S-Specific Transcription Assembly of the ORC complex at the origin of replication Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin E2F-enabled inhibition of pre-replication complex formation Cell Cycle Checkpoints CDT1 association with the CDC6:ORC:origin complex Association of licensing factors with the pre-replicative complex	Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: CDC45 CDC5L CDC6 CDC7 CDK2 CDT1 DBF4 GOLGA2 KAT7 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RPA2 SKP2 XPO1	31 interactors: ALS2CR11 CCNA1 CDC45 CDC7 CDKN2A CDT1 CRLS1 DBF4 FAM161A GMNN HDAC1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MLLT3 NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 RPA1 SCNM1 SMC1A SNRPB2 ZBTB9
Entrez ID		4998	4175
HPRD ID		03544	03485
Ensembl ID		ENSG00000085840	ENSG00000076003
Uniprot IDs		B7Z8H0 Q13415 Q96F82	Q14566
PDB IDs			2KLQ 2LE8
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication Mitotic Cell Cycle DNA Replication Initiation Cell Cycle Mitotic Cell Cycle Process Cell Cycle Process DNA Metabolic Process DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA Duplex Unwinding DNA Geometric Change DNA Unwinding Involved In DNA Replication Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Process Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Chromosome Organization DNA Replication Checkpoint DNA Conformation Change Double-strand Break Repair Via Break-induced Replication Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of DNA Replication Cellular Response To DNA Damage Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Cellular Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Regulation Of DNA-dependent DNA Replication Initiation Regulation Of Mitotic Cell Cycle Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Cell Cycle Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of DNA-dependent DNA Replication Positive Regulation Of Cell Cycle Organelle Organization	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle DNA Replication Mitotic Cell Cycle Process DNA-dependent DNA Replication DNA Replication Initiation Cell Cycle Cell Cycle Process DNA Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Duplex Unwinding DNA Geometric Change DNA Unwinding Involved In DNA Replication Chromosome Organization Cellular Metabolic Process DNA Conformation Change Regulation Of Cell Cycle Double-strand Break Repair Via Break-induced Replication Regulation Of Cell Cycle Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Double-strand Break Repair Cellular Response To Stress Regulation Of Nuclear Cell Cycle DNA Replication DNA Replication Checkpoint Cellular Process Positive Regulation Of Cell Cycle Process Cell Cycle Checkpoint DNA Recombination Organelle Organization Negative Regulation Of Cell Cycle
Tagcloud ?		assemble atpase cdc6 cdt1 cerevisiae cooperates dimerization double helicase hexamer hexamers hydrolysis illustrate loaded loading mcm2 motifs onto origin origins recruitment releasing replicative restricts saccharomyces sensor stranded walker	benign bronchial brushing brushings clinicopathologic considerable consisting cytology detecting icbp90 immunocytochemistry inpatients ki67 kiaa0317 kiaa1522 ligase lung mcm7 minichromosome nonsmall nsclc outpatients panel sclc specimens tp53 tp63 uhr1 uncharacterized
Tagcloud (Difference) ?		assemble atpase cdc6 cdt1 cerevisiae cooperates dimerization double helicase hexamer hexamers hydrolysis illustrate loaded loading mcm2 motifs onto origin origins recruitment releasing replicative restricts saccharomyces sensor stranded walker	benign bronchial brushing brushings clinicopathologic considerable consisting cytology detecting icbp90 immunocytochemistry inpatients ki67 kiaa0317 kiaa1522 ligase lung mcm7 minichromosome nonsmall nsclc outpatients panel sclc specimens tp53 tp63 uhr1 uncharacterized
Tagcloud (Intersection) ?