SV2B and SYT1

Number of citations of the paper that reports this interaction (PubMedID 15466855)
0

Data Source:
HPRD (in vitro)

		SV2B	SYT1
Description		synaptic vesicle glycoprotein 2B	synaptotagmin 1
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Synapse	Cytoplasm Golgi Apparatus Plasma Membrane Synaptic Vesicle Postsynaptic Density Membrane Secretory Granule Axon Transport Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Chromaffin Granule Membrane Presynaptic Membrane Neuron Projection Neuron Projection Terminus Synapse Postsynaptic Membrane Presynaptic Active Zone Excitatory Synapse Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane Exocytic Vesicle Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Protein Binding Transmembrane Transporter Activity	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calmodulin Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Syntaxin-1 Binding Syntaxin Binding Clathrin Binding Syntaxin-3 Binding Identical Protein Binding Metal Ion Binding Protein Heterodimerization Activity Calcium-dependent Protein Binding Low-density Lipoprotein Particle Receptor Binding Calcium Ion Sensor Activity Molecular Condensate Scaffold Activity
	Biological Process	Neurotransmitter Transport Chemical Synaptic Transmission Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Synaptic Vesicle Exocytosis	Detection Of Calcium Ion Vesicle Fusion Chemical Synaptic Transmission Neurotransmitter Secretion Regulation Of Dopamine Secretion Vesicle Organization Synaptic Vesicle Exocytosis Vesicle-mediated Transport Regulation Of Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Cell Differentiation Regulation Of Vesicle Fusion Positive Regulation Of Vesicle Fusion Positive Regulation Of Dopamine Secretion Positive Regulation Of Calcium Ion-dependent Exocytosis Vesicle Docking Calcium Ion-regulated Exocytosis Of Neurotransmitter Positive Regulation Of Synaptic Transmission Protein Heterooligomerization Response To Calcium Ion Regulation Of Synaptic Transmission, Glutamatergic Spontaneous Neurotransmitter Secretion Cellular Response To Calcium Ion Synchronous Neurotransmitter Secretion Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcium-dependent Activation Of Synaptic Vesicle Fusion Membraneless Organelle Assembly Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Regulated Secretory Pathway Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis
Pathways		Toxicity of botulinum toxin type D (botD) Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type F (botF) Toxicity of botulinum toxin type E (botE)	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Toxicity of botulinum toxin type B (botB) Toxicity of botulinum toxin type G (botG) Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis GABA synthesis, release, reuptake and degradation
Drugs
Diseases
GWAS		Age-related hearing impairment ( 24939585) Gout (normal type) ( 32238385) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295) Metabolite levels ( 19043545 23823483) Neuritic plaque ( 31497858) Primary sclerosing cholangitis ( 27992413) Rosacea symptom severity ( 29771307)	Adiponectin levels ( 33562295) Brain morphology (MOSTest) ( 32665545) Chloride levels ( 29403010) Estimated glomerular filtration rate ( 31217584) Fasting insulin ( 34059833) General cognitive ability ( 29844566) Hand grip strength ( 29313844) Intelligence (MTAG) ( 29326435) Lung function ( 31902109) Lysophosphatidylcholine levels ( 31551469) Obesity-related traits ( 23251661) Pulse pressure ( 30578418) QRS duration ( 31251759) Sodium levels ( 29403010) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653)
Interacting Genes		2 interacting genes: HSFY1 SYT1	46 interacting genes: BNIP2 BTN2A2 CACNA1A CACNB3 CACNB4 CALM1 CREBBP CSGALNACT2 CYB5B DANCR FGF1 GIMAP5 GOLM1 HMOX2 IKBKG IRF3 MIP NAPB NEDD4 NR1H3 NR3C1 NRXN1 PPARG RACK1 RBM14 RIMS1 S100A13 SIN3A SMAD2 SNAP25 STON2 STX1A STX2 STX3 STX4 SV2B SYNCRIP SYT4 TFAP2A TMEM14C TMEM254 TMEM60 TSHR UBIAD1 ZDHHC17 ZFPL1
Entrez ID		9899	6857
HPRD ID		11765	01710
Ensembl ID		ENSG00000185518	ENSG00000067715
Uniprot IDs		Q7L1I2	J3KQA0 P21579
PDB IDs		8UO8 9F1R 9F2B 9F2J 9F2Y 9F3C	2K45 2K4A 2K8M 2KI6 2LHA 2N1T 2R83 3F00 3F01 3F04 3F05 4ISQ 4V11 6G5F 6G5K 6QNS 6TZ3 6U41 6U4U 6U4W 6ZVN 7TUA 7TX9 7U4Q 8B8I
Enriched GO Terms of Interacting Partners?		Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Synchronous Neurotransmitter Secretion Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Syntaxin-3 Binding Positive Regulation Of Synaptic Vesicle Exocytosis Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Spontaneous Neurotransmitter Secretion Chromaffin Granule Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Dopamine Secretion Clathrin-sculpted Monoamine Transport Vesicle Membrane Calcium Ion-regulated Exocytosis Of Neurotransmitter Calcium-dependent Activation Of Synaptic Vesicle Fusion Positive Regulation Of Catecholamine Secretion Positive Regulation Of Neurotransmitter Secretion Neuron Projection Terminus Dense Core Granule Positive Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Dendrite Extension Detection Of Calcium Ion Calcium Ion Sensor Activity Positive Regulation Of Vesicle Fusion Syntaxin-1 Binding Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Low-density Lipoprotein Particle Receptor Binding Exocytic Vesicle Regulation Of Dopamine Secretion Protein Heterooligomerization Presynaptic Cytosol Postsynaptic Cytosol Excitatory Synapse Calcium-ion Regulated Exocytosis Regulation Of Vesicle Fusion Clathrin Binding Synaptic Vesicle Exocytosis Regulation Of Catecholamine Secretion Regulation Of Calcium Ion-dependent Exocytosis Neurotransmitter Secretion Presynaptic Active Zone Hippocampal Mossy Fiber To CA3 Synapse Syntaxin Binding Positive Regulation Of Regulated Secretory Pathway Calcium-dependent Phospholipid Binding Molecular Condensate Scaffold Activity Regulation Of Synaptic Vesicle Exocytosis Transport Vesicle Membrane Phosphatidylserine Binding Vesicle Docking	Neurotransmitter Transport Organelle Localization By Membrane Tethering Modulation Of Chemical Synaptic Transmission Membrane Docking Vesicle Docking SNARE Binding Organelle Localization Positive Regulation Of Cell Communication Positive Regulation Of Signaling SNAP Receptor Activity Calcium-dependent Protein Binding Secretion By Cell Secretion SNARE Complex Vesicle-mediated Transport In Synapse Membrane Fusion Vesicle Fusion Regulation Of Cell Communication Regulation Of Signaling Organelle Membrane Fusion Synapse Regulation Of Regulated Secretory Pathway Exocytosis Vesicle-mediated Transport Organelle Fusion Chemical Synaptic Transmission Glutamatergic Synapse Positive Regulation Of Signal Transduction Positive Regulation Of Synaptic Transmission Trans-synaptic Signaling Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Neurotransmitter Secretion Regulation Of Protein Localization Synaptic Signaling Regulation Of Biological Quality Synaptic Vesicle Docking Signal Release Establishment Of Localization In Cell Calcium Channel Regulator Activity Positive Regulation Of Immune Response Regulation Of Synaptic Vesicle Exocytosis Regulation Of Exocytosis Somatodendritic Compartment Regulation Of Vesicle-mediated Transport Activation Of Immune Response Long-term Synaptic Potentiation Regulation Of Secretion By Cell Regulation Of Membrane Potential Cell-cell Signaling Presynaptic Membrane
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