ZMIZ1 and TBC1D4

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		ZMIZ1	TBC1D4
Gene Name		zinc finger, MIZ-type containing 1	TBC1 domain family, member 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Nuclear Speck Intracellular Membrane-bounded Organelle	Cytoplasm Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Zinc Ion Binding	Rab GTPase Activator Activity
	Biological Process	Vasculogenesis In Utero Embryonic Development Heart Morphogenesis Transcription, DNA-templated Vitellogenesis Cell Aging Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Developmental Growth Artery Morphogenesis	Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Positive Regulation Of Rab GTPase Activity Cellular Response To Insulin Stimulus Membrane Organization
Pathways			Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Breast cancer ( 23535729 20453838) Celiac disease ( 20190752) Crohn's disease ( 21102463) Crohn's disease and psoriasis ( 22482804) Height ( 23563607) Inflammatory bowel disease (early onset) ( 19915574) Multiple sclerosis ( 22190364 19525953 21833088) Vitiligo ( 20526339)	Diabetic retinopathy ( 23562823) Heart failure ( 20445134)
Protein-Protein Interactions		5 interactors: AR CACHD1 CNTNAP2 PIAS3 TBC1D4	14 interactors: AKT1 CDK5RAP2 EP400 FAM208A KIAA1551 NAV1 NFAT5 PIN1 RBM12 TET2 TOPBP1 U2SURP YWHAG ZMIZ1
Entrez ID		57178	9882
HPRD ID		12115	18164
Ensembl ID		ENSG00000108175	ENSG00000136111
Uniprot IDs		A0JLS3 Q9ULJ6	O60343
PDB IDs			3QYB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Integrin Biosynthetic Process Superior Temporal Gyrus Development Response To Hormone Clustering Of Voltage-gated Potassium Channels Positive Regulation Of Integrin Biosynthetic Process Regulation Of Integrin Biosynthetic Process Negative Regulation Of Vesicle Fusion Positive Regulation Of Transcription From RNA Polymerase III Promoter Protein Localization To Juxtaparanode Region Of Axon Neuronal Ion Channel Clustering Positive Regulation Of Protein Sumoylation Thalamus Development Vocalization Behavior Striatum Development	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Cycle Checkpoint Positive Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition Microtubule Bundle Formation Positive Regulation Of Mitochondrion Organization Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process 5-methylcytosine Catabolic Process Glycogen Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Organelle Organization Peptidyl-amino Acid Modification Negative Regulation Of Phosphorylation Regulation Of Mitochondrion Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Vitellogenesis Regulation Of Cell Cycle Process Organelle Organization G2/M Transition Of Mitotic Cell Cycle Cytosine Metabolic Process Regulation Of Neuron Differentiation Liver Morphogenesis Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Centriole Replication Hematopoietic Stem Cell Homeostasis Cell Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of MAPK Cascade Response To UV-A Activation-induced Cell Death Of T Cells Oxidative DNA Demethylation Mitotic Cell Cycle Process Intrinsic Apoptotic Signaling Pathway Regulation Of Neurogenesis Myeloid Progenitor Cell Differentiation Cytoplasm Organization Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Apoptotic Signaling Pathway Generation Of Neurons Cellular Response To Insulin Stimulus Mitotic Cell Cycle Negative Regulation Of Protein Kinase Activity
Tagcloud ?		10q22 11q13 16p13 17q21 19p13 22q11 9p24 crohn enlarge epidemiologically exonic fut2 il12b il23r near pathologically prdx5 ps refinement rel rs1250544 rs181359 rs4780355 rs694739 shared socs1 therapeutically tyk2 ydjc	amp elucidate evidenced fasting glucose glycogen homeostasis irs1 knock lethality member mnuak1ko motility muscle nuak1 null oxidative phenotypic phosphoproteome physiological preferentially senescence ser soleus suppress thr tolerance tyr understand
Tagcloud (Difference) ?		10q22 11q13 16p13 17q21 19p13 22q11 9p24 crohn enlarge epidemiologically exonic fut2 il12b il23r near pathologically prdx5 ps refinement rel rs1250544 rs181359 rs4780355 rs694739 shared socs1 therapeutically tyk2 ydjc	amp elucidate evidenced fasting glucose glycogen homeostasis irs1 knock lethality member mnuak1ko motility muscle nuak1 null oxidative phenotypic phosphoproteome physiological preferentially senescence ser soleus suppress thr tolerance tyr understand
Tagcloud (Intersection) ?