ZMIZ1 and PIAS3

Number of citations of the paper that reports this interaction (PMID 20159969)
5

Data Source:
BioGRID (two hybrid)

		ZMIZ1	PIAS3
Gene Name		zinc finger, MIZ-type containing 1	protein inhibitor of activated STAT, 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Nuclear Speck Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Dendrite Synapse
	Molecular Function	Zinc Ion Binding	Protein Binding Protein C-terminus Binding Zinc Ion Binding Potassium Channel Regulator Activity Ligase Activity SUMO Transferase Activity Enzyme Binding Protein N-terminus Binding
	Biological Process	Vasculogenesis In Utero Embryonic Development Heart Morphogenesis Transcription, DNA-templated Vitellogenesis Cell Aging Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Developmental Growth Artery Morphogenesis	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Response To Hormone Positive Regulation Of Gene Expression Protein Sumoylation Positive Regulation Of Protein Sumoylation Positive Regulation Of Membrane Potential
Pathways
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Breast cancer ( 23535729 20453838) Celiac disease ( 20190752) Crohn's disease ( 21102463) Crohn's disease and psoriasis ( 22482804) Height ( 23563607) Inflammatory bowel disease (early onset) ( 19915574) Multiple sclerosis ( 22190364 19525953 21833088) Vitiligo ( 20526339)
Protein-Protein Interactions		5 interactors: AR CACHD1 CNTNAP2 PIAS3 TBC1D4	49 interactors: AR ATF7IP C19orf60 CARHSP1 CBS CREM EP300 ESR1 ESR2 GEMIN4 GFI1 GLUL HABP4 HDAC1 HMGA2 MITF NCOA2 NR3C2 OPN1LW PGR PPP1CA PRPF40A PSMC1 RAC1 RELA SATB1 SERBP1 SERPINA10 SIAH1 SIAH2 SKIL SMAD2 SMAD3 SMAD4 SREBF2 STAT3 SUMO1 SUMO2 SUMO3 TBP TRIM27 TRIM32 TRIM55 TRIM63 UBA1 UBE2I ZFHX3 ZMIZ1 ZMIZ2
Entrez ID		57178	10401
HPRD ID		12115	09068
Ensembl ID		ENSG00000108175	ENSG00000131788
Uniprot IDs		A0JLS3 Q9ULJ6	B3KNI3 Q6IAR4 Q9Y6X2
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Integrin Biosynthetic Process Superior Temporal Gyrus Development Response To Hormone Clustering Of Voltage-gated Potassium Channels Positive Regulation Of Integrin Biosynthetic Process Regulation Of Integrin Biosynthetic Process Negative Regulation Of Vesicle Fusion Positive Regulation Of Transcription From RNA Polymerase III Promoter Protein Localization To Juxtaparanode Region Of Axon Neuronal Ion Channel Clustering Positive Regulation Of Protein Sumoylation Thalamus Development Vocalization Behavior Striatum Development	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Metabolic Process Gene Expression Transcription Initiation From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA-templated Transcription, Initiation Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Response To Organic Substance Regulation Of Cellular Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Viral Process Cellular Response To Organic Substance Biosynthetic Process Epithelium Development Regulation Of Signal Transduction Regulation Of Cell Death Regulation Of Signaling Response To Stimulus Cellular Response To Stimulus
Tagcloud ?		10q22 11q13 16p13 17q21 19p13 22q11 9p24 crohn enlarge epidemiologically exonic fut2 il12b il23r near pathologically prdx5 ps refinement rel rs1250544 rs181359 rs4780355 rs694739 shared socs1 therapeutically tyk2 ydjc	achieved atm atr consistently crucial dbc1 deficient diverse establish etoposide finely genotoxic interaction knockdown metabolism modification modifier promoted promotion remarkably senp1 sirt1 sumo sumo1 sumo2 sumoylation switching transactivation ubiquitin
Tagcloud (Difference) ?		10q22 11q13 16p13 17q21 19p13 22q11 9p24 crohn enlarge epidemiologically exonic fut2 il12b il23r near pathologically prdx5 ps refinement rel rs1250544 rs181359 rs4780355 rs694739 shared socs1 therapeutically tyk2 ydjc	achieved atm atr consistently crucial dbc1 deficient diverse establish etoposide finely genotoxic interaction knockdown metabolism modification modifier promoted promotion remarkably senp1 sirt1 sumo sumo1 sumo2 sumoylation switching transactivation ubiquitin
Tagcloud (Intersection) ?