TASOR and AP2M1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TASOR	AP2M1
Description		transcription activation suppressor	adaptor related protein complex 2 subunit mu 1
Image
GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Chromosome	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Membrane AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Synapse Clathrin-coated Endocytic Vesicle Extracellular Exosome Postsynapse Extrinsic Component Of Presynaptic Endocytic Zone Membrane Glutamatergic Synapse
	Molecular Function	Chromatin Binding RNA Binding Protein Binding	Signal Sequence Binding Protein Binding Lipid Binding Clathrin Adaptor Activity Transmembrane Transporter Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding
	Biological Process	Anterior/posterior Axis Specification, Embryo Negative Regulation Of Gene Expression, Epigenetic Mesodermal To Mesenchymal Transition Involved In Gastrulation Protein Localization To Heterochromatin Constitutive Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation	Positive Regulation Of Receptor Internalization Intracellular Protein Transport Endocytosis Vesicle Budding From Membrane Protein Transport Vesicle-mediated Transport Receptor Internalization Synaptic Vesicle Endocytosis Protein-containing Complex Assembly Clathrin-dependent Endocytosis Regulation Of Vesicle Size Postsynaptic Neurotransmitter Receptor Internalization Vesicle-mediated Transport In Synapse Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Major depressive disorder ( 22472876)
Interacting Genes		5 interacting genes: AP2M1 RB1 RNF10 TBC1D4 TOM1L1	86 interacting genes: ADRA1B AGTR1 AP2B1 AQP4 ARRB2 ATG9A ATXN1L BDKRB2 C1orf35 CACNA1A CD22 CD2BP2 CD3D CDK11B CEBPA CLK2 CORO7 CSNK2B CTLA4 CXorf51A CXorf51B DAB2 DCX DPPA2 DVL2 EAF1 EHD2 EIF1AD FAM90A1 FURIN FXR2 GAK GRIN2A GRIN2B H2BC10 H2BC13 H2BC21 H2BC4 H2BC6 H2BC7 H2BC8 HEXIM2 HOOK2 HTR6 IKZF1 IRS2 KCNJ11 KNOP1 LAMP1 LTB4R2 LUC7L2 LY9 MAB21L3 MED4 MEGF10 MFAP1 MPP1 MTURN NAA11 NCOR2 NDRG1 NKAPD1 PRPF18 PRPF38A PRR13 PTS RALBP1 RNF111 RPL22 RPL38 RRP12 RSPH14 RUNDC3A SFRP4 SNCA SPATS2 STON2 SYNJ1 TASOR TBC1D5 TGOLN2 TIAM1 TMA16 UBC ZBTB8A ZNF581
Entrez ID		23272	1173
HPRD ID		10183	03014
Ensembl ID		ENSG00000163946	ENSG00000161203
Uniprot IDs		Q9UK61	B4DNB9 E9PFW3 Q96CW1
PDB IDs		6SWG 6TL1	1H6E 6BNT 6URI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Glial Cell Proliferation Disordered Domain Specific Binding Negative Regulation Of Gliogenesis Regulation Of Glial Cell Proliferation Positive Regulation Of Synaptic Vesicle Endocytosis Regulation Of Cellular Component Organization Positive Regulation Of Synaptic Vesicle Recycling Postsynaptic Neurotransmitter Receptor Internalization Signal Sequence Binding Extrinsic Component Of Presynaptic Endocytic Zone Membrane Regulation Of Gliogenesis Negative Regulation Of Cell Cycle Process Negative Regulation Of Myofibroblast Differentiation Sister Chromatid Biorientation Negative Regulation Of Nervous System Development Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Regulation Of Mitotic Nuclear Division Regulation Of Myofibroblast Differentiation Negative Regulation Of Hepatocyte Apoptotic Process Enucleate Erythrocyte Differentiation Cellular Response To Insulin Stimulus Glial Cell Apoptotic Process Regulation Of Nuclear Division Negative Regulation Of Mitotic Cell Cycle Response To Insulin Negative Regulation Of Cell Development Rb-E2F Complex Regulation Of Protein Kinase Activity Regulation Of Centromere Complex Assembly Cellular Response To Peptide Hormone Stimulus Regulation Of Collagen Fibril Organization Cyclin/CDK Positive Transcription Elongation Factor Complex Regulation Of Kinase Activity Chromatin Lock Complex Importin-alpha Family Protein Binding Negative Regulation Of Neurogenesis Positive Regulation Of Collagen Fibril Organization Negative Regulation Of Vesicle Fusion Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Positive Regulation Of Protein Autophosphorylation AP-2 Adaptor Complex Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Organelle Organization Response To Peptide Hormone Clathrin Adaptor Complex Cellular Response To Hormone Stimulus	Innate Immune Response In Mucosa Mucosal Immune Response Organ Or Tissue Specific Immune Response Protein-containing Complex Organization Protein-containing Complex Assembly Protein Heterodimerization Activity Structural Constituent Of Chromatin Antibacterial Humoral Response Nucleosome Assembly Protein Domain Specific Binding Nucleosome Nucleosome Organization Protein-DNA Complex Assembly AP-2 Adaptor Complex Import Into Cell Endocytosis Receptor-mediated Endocytosis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response To Gram-positive Bacterium Synaptic Vesicle Endocytosis Synaptic Vesicle Uncoating Presynaptic Endocytosis Trans-synaptic Signaling Clathrin Adaptor Activity Synaptic Signaling Clathrin Coat Assembly Nucleoplasm Positive Regulation Of Receptor-mediated Endocytosis Clathrin-coated Endocytic Vesicle Antimicrobial Humoral Response Positive Regulation Of Endocytosis Clathrin Coat Disassembly Regulation Of Neuronal Synaptic Plasticity Regulation Of Endocytosis Chemical Synaptic Transmission Excitatory Postsynaptic Potential Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Vesicle Uncoating Nucleus Positive Regulation Of Receptor Internalization Synaptic Membrane Protein Binding Cellular Component Assembly NMDA Glutamate Receptor Activity Synapse Clathrin-dependent Endocytosis Synaptic Vesicle Regulation Of Vesicle-mediated Transport NMDA Selective Glutamate Receptor Complex
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