PPARA and MED24

Number of citations of the paper that reports this interaction (PMID 9653119)
98

Data Source:
HPRD (in vitro)

		PPARA	MED24
Gene Name		peroxisome proliferator-activated receptor alpha	mediator complex subunit 24
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Mediator Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Repressing Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Drug Binding Zinc Ion Binding Lipid Binding Phosphatase Binding Protein Domain Specific Binding Ubiquitin Conjugating Enzyme Binding Protein Complex Binding Sequence-specific DNA Binding NFAT Protein Binding MDM2/MDM4 Family Protein Binding	RNA Polymerase II Transcription Cofactor Activity Transcription Cofactor Activity Histone Acetyltransferase Activity Receptor Activity Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Fatty Acid Metabolic Process Heart Development Circadian Rhythm Epidermis Development Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Cholesterol Storage Negative Regulation Of Sequestering Of Triglyceride Fatty Acid Transport Intracellular Receptor Signaling Pathway Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Protein Binding Negative Regulation Of Appetite Response To Insulin Circadian Regulation Of Gene Expression Behavioral Response To Nicotine Wound Healing Lipoprotein Metabolic Process Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Gluconeogenesis Negative Regulation Of Blood Pressure Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fatty Acid Oxidation Enamel Mineralization Regulation Of Glycolytic By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Neuron Death Negative Regulation Of Transcription Regulatory Region DNA Binding	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Histone Acetylation Stem Cell Maintenance Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Protein Heterooligomerization
Pathways		PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Nuclear Receptor transcription pathway REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs		Clofibrate Fenofibrate Gemfibrozil Bezafibrate Deoxy-Bigchap 2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid ALEGLITAZAR
Diseases
GWAS			White blood cell count ( 20139978 21738480)
Protein-Protein Interactions		44 interactors: AIP AKAP13 CDK3 CEP350 CHD9 DAP3 DUT EP300 FABP1 FOXA3 GADD45A GADD45B GADD45G HELZ2 HSP90AA1 MAPK1 MAPK3 MECR MED1 MED24 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR1H3 NRBF2 NRIP1 POU1F1 PPARGC1A PPARGC1B PRKCA PRKCD PRMT1 PRMT8 RELA RXRA RXRG SIRT1 SRC STAC3 SUMO1 TNP1 UBE2I	14 interactors: APP AR CTDP1 ESR1 ESR2 GSK3B HNF4A MED9 PPARA PPARG RPS6KA6 RXRA SREBF1 TNFSF11
Entrez ID		5465	9862
HPRD ID		01369	06107
Ensembl ID		ENSG00000186951	ENSG00000008838
Uniprot IDs		F1D8S4 Q07869	O75448
PDB IDs		1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Transcription, DNA-templated Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Response To Hormone DNA-templated Transcription, Initiation Organelle Organization Regulation Of Gene Expression Cellular Response To Organic Substance Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Chromatin Modification Negative Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Regulation Of Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Response To Organic Substance Peptidyl-amino Acid Modification Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Androgen Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Regulation Of Signaling Signal Transduction Response To Steroid Hormone Negative Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Cell Communication Nucleobase-containing Compound Metabolic Process	Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Lipid Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Response To Steroid Hormone Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Cellular Response To Hormone Stimulus Cellular Response To Organic Cyclic Compound Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Response To Lipid Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Organic Cyclic Compound Response To Hormone Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organ Development Transcription, DNA-templated System Development Prostate Gland Development RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Metabolic Process Response To Organic Substance Positive Regulation Of Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Anatomical Structure Development Cellular Nitrogen Compound Metabolic Process Rhythmic Process Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Signaling Developmental Process
Tagcloud ?		abca1 alfalfa aragonesa breed concentrate contrary dams finishing grazed grazing indoors lambs lengths lpl lt pparg rasa scarb1 sf slaughtering srebp1 subcutaneous supplemented thoracis tocopherol tocopheryl ve10d ve20d ve30d	abundant attenuated branching communicates communications double ductal e2f1 employing ers functionally gland glands haploinsufficient heterozygous knockout lactation luciferase luminal mammary med1 med30 mediator normally profound pubertal puberty retardation submodule
Tagcloud (Difference) ?		abca1 alfalfa aragonesa breed concentrate contrary dams finishing grazed grazing indoors lambs lengths lpl lt pparg rasa scarb1 sf slaughtering srebp1 subcutaneous supplemented thoracis tocopherol tocopheryl ve10d ve20d ve30d	abundant attenuated branching communicates communications double ductal e2f1 employing ers functionally gland glands haploinsufficient heterozygous knockout lactation luciferase luminal mammary med1 med30 mediator normally profound pubertal puberty retardation submodule
Tagcloud (Intersection) ?