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PPARA and MECR
Number of citations of the paper that reports this interaction (PubMedID
9795230
)
0
Data Source:
HPRD
(two hybrid, in vitro)
PPARA
MECR
Description
peroxisome proliferator activated receptor alpha
mitochondrial trans-2-enoyl-CoA reductase
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
RNA Polymerase II Transcription Regulator Complex
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Membrane
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity
Transcription Coactivator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Steroid Receptor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Lipid Binding
Phosphatase Binding
Protein Domain Specific Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Ubiquitin Conjugating Enzyme Binding
Signaling Receptor Activity
Sequence-specific DNA Binding
Protein-containing Complex Binding
Metal Ion Binding
NFAT Protein Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
MDM2/MDM4 Family Protein Binding
DNA-binding Transcription Factor Binding
Oxidoreductase Activity
Enoyl-[acyl-carrier-protein] Reductase (NADPH) Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Response To Hypoxia
Gluconeogenesis
Regulation Of DNA-templated Transcription
Lipid Metabolic Process
Fatty Acid Metabolic Process
Heart Development
Response To Nutrient
Lactation
Epidermis Development
Cellular Response To Starvation
Hormone-mediated Signaling Pathway
Gene Expression
Regulation Of Gene Expression
Regulation Of Ketone Metabolic Process
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Cholesterol Storage
Regulation Of Fatty Acid Metabolic Process
Cell Differentiation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Intracellular Receptor Signaling Pathway
Positive Regulation Of Fatty Acid Beta-oxidation
Negative Regulation Of Appetite
Response To Insulin
Circadian Regulation Of Gene Expression
Behavioral Response To Nicotine
Peroxisome Proliferator Activated Receptor Signaling Pathway
Wound Healing
Lipoprotein Metabolic Process
Regulation Of Circadian Rhythm
Response To Ethanol
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Blood Pressure
Negative Regulation Of Glycolytic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Fatty Acid Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Nitric Oxide Metabolic Process
Positive Regulation Of Fatty Acid Oxidation
Positive Regulation Of Lipid Biosynthetic Process
Rhythmic Process
Negative Regulation Of Inflammatory Response
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Enamel Mineralization
Cellular Response To Fructose Stimulus
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of MiRNA Transcription
Negative Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Negative Regulation Of Hepatocyte Apoptotic Process
Positive Regulation Of Transformation Of Host Cell By Virus
Regulation Of Fatty Acid Transport
Positive Regulation Of ATP Biosynthetic Process
Lipid Metabolic Process
Fatty Acid Metabolic Process
Fatty Acid Biosynthetic Process
Intracellular Iron Ion Homeostasis
Ceramide Biosynthetic Process
Pathways
BMAL1:CLOCK,NPAS2 activates circadian expression
PPARA activates gene expression
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
SUMOylation of intracellular receptors
Cytoprotection by HMOX1
Heme signaling
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Expression of BMAL (ARNTL), CLOCK, and NPAS2
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Drugs
alpha-Linolenic acid
Icosapent
Troglitazone
Valproic acid
Indomethacin
Rosiglitazone
Fenoprofen
Clofibrate
Fenofibrate
Ibuprofen
Amiodarone
Gemfibrozil
Bezafibrate
Prasterone
N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide
Flufenamic acid
Resveratrol
Phthalic Acid
Lauric acid
Stearic acid
Doconexent
Palmitic Acid
Oleic Acid
Caprylic acid
Arachidonic Acid
Reglitazar
Elafibranor
Cardarine
Muraglitazar
Ertiprotafib
Ragaglitazar
Tesaglitazar
GW-590735
Indeglitazar
Myristic acid
Aleglitazar
Clinofibrate
Ciprofibrate
Dexibuprofen
Soybean oil
Omega-3 fatty acids
Myrrh
Isoflavone
Leukotriene B4
Fenofibric acid
Fish oil
Diseases
GWAS
Cholesterol, total (
24097068
)
CTACK levels (
27989323
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Hip circumference adjusted for BMI (
34021172
)
Impulsivity (motor) (
30718321
)
LDL cholesterol (
24097068
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Refractive error (
32231278
)
Resting-state electroencephalogram vigilance (
29703947
)
Triglyceride levels (
32203549
)
Type 2 diabetes (
31049640
)
Very long-chain saturated fatty acid levels (fatty acid 20:0) (
25378659
)
Carotid plaque maximum area (
32469969
)
Diastolic blood pressure (
30224653
)
Low density lipoprotein cholesterol levels (
32154731
)
Mean area of carotid plaque (
32469969
)
Schizophrenia (
26531332
)
Tourette syndrome (
30818990
)
Interacting Genes
70 interacting genes:
AIP
AKAP13
ANKRD11
AQP1
BCL2
CCDC179
CDC34
CDK3
CEP350
CHD9
CHIC2
COL8A1
CTNNA3
DAP3
DUT
EP300
EXOSC4
FABP1
FAM90A1
FAM9B
FBLN1
FOXA3
GADD45A
GADD45B
GADD45G
GPANK1
HELZ2
HOXC8
HSP90AA1
KCTD7
KRTAP10-1
LAMTOR5
MAPK1
MAPK3
MECR
MED1
MED24
NCOA1
NCOA2
NCOA3
NCOR1
NCOR2
NR1H2
NR1H3
NRBF2
NRIP1
PAQR3
PICK1
PIK3R3
POU1F1
PPARGC1A
PPARGC1B
PRKCA
PRKCD
PRMT1
PRMT8
RELA
RXRA
RXRG
SDCBP
SIRT1
STAC3
TNP1
TRIM55
TRIM63
UBE2I
VWA5A
VWC2L
ZNF587
ZSCAN23
5 interacting genes:
HNF4A
PPARA
RARA
RXRA
THRB
Entrez ID
5465
51102
HPRD ID
01369
12192
Ensembl ID
ENSG00000186951
ENSG00000116353
Uniprot IDs
F1D8S4
Q07869
Q9BV79
PDB IDs
1I7G
1K7L
1KKQ
2NPA
2P54
2REW
2ZNN
3ET1
3FEI
3G8I
3KDT
3KDU
3SP6
3VI8
4BCR
4CI4
5AZT
5HYK
6KAX
6KAY
6KAZ
6KB0
6KB1
6KB2
6KB3
6KB4
6KB5
6KB6
6KB7
6KB8
6KB9
6KBA
6KXX
6KXY
6KYP
6L36
6L37
6L38
6L96
6LX4
6LX5
6LX6
6LX7
6LX8
6LX9
6LXA
6LXB
6LXC
7BPY
7BPZ
7BQ0
7BQ1
7BQ2
7BQ3
7BQ4
7C6Q
7E5F
7E5G
7E5H
7E5I
8HUK
8HUN
8HUQ
8RCE
1ZSY
2VCY
7AYB
7AYC
Enriched GO Terms of Interacting Partners
?
Nuclear Receptor Binding
Nucleoplasm
Nuclear Receptor-mediated Signaling Pathway
Peroxisome Proliferator Activated Receptor Signaling Pathway
Nucleus
Transcription Coactivator Activity
Intracellular Receptor Signaling Pathway
Transcription Coregulator Activity
Intracellular Signal Transduction
Hormone-mediated Signaling Pathway
Regulation Of Gene Expression
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Biosynthetic Process
MRNA Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Response To Lipid
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
MRNA Transcription
Response To Hormone
Chromatin
Response To Steroid Hormone
Positive Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Nuclear Retinoic Acid Receptor Binding
Response To Nutrient Levels
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nuclear Retinoid X Receptor Binding
Regulation Of Lipid Metabolic Process
Regulation Of Small Molecule Metabolic Process
Cellular Response To Nutrient Levels
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cholesterol Efflux
Regulation Of Macromolecule Metabolic Process
DNA-templated Transcription
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Chromatin DNA Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Lipid Metabolic Process
Regulation Of Primary Metabolic Process
Nucleobase-containing Compound Biosynthetic Process
Retinoic Acid Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Transcription By RNA Polymerase II
Response To Starvation
Nuclear Receptor Activity
Intracellular Receptor Signaling Pathway
Nuclear Receptor-mediated Signaling Pathway
Retinoic Acid Receptor Signaling Pathway
RNA Polymerase II Transcription Regulator Complex
Hormone-mediated Signaling Pathway
Sequence-specific DNA Binding
Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway
MRNA Transcription By RNA Polymerase II
Transcription Coactivator Binding
MRNA Transcription
DNA-binding Transcription Factor Activity
Macromolecule Biosynthetic Process
Regulation Of Thyroid Hormone Receptor Signaling Pathway
Transcription By RNA Polymerase II
Retinoic Acid-responsive Element Binding
Nuclear Protein Quality Control By The Ubiquitin-proteasome System
Regulation Of Lipid Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Intracellular Signal Transduction
Positive Regulation Of RNA Metabolic Process
Regulation Of Circadian Rhythm
Peroxisome Proliferator Activated Receptor Signaling Pathway
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Lipid Metabolic Process
Chromatin
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Response To Nutrient
Negative Regulation Of Macromolecule Biosynthetic Process
Retinoic Acid Binding
Negative Regulation Of Biosynthetic Process
Nuclear Steroid Receptor Activity
Positive Regulation Of Transcription By RNA Polymerase II
Cell Differentiation
Negative Regulation Of DNA-templated Transcription
Sequence-specific Double-stranded DNA Binding
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of MiRNA Transcription
Response To Hormone
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Multicellular Organismal Development
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Regulation Of Response To Nutrient Levels
Positive Regulation Of Biosynthetic Process
Positive Regulation Of ATP Metabolic Process
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Tagcloud (Intersection)
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