PPARA and STAC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PPARA	STAC3
Description		peroxisome proliferator activated receptor alpha	SH3 and cysteine rich domain 3
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cytoplasmic Side Of Plasma Membrane Membrane T-tubule Sarcolemma Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Lipid Binding Phosphatase Binding Protein Domain Specific Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Conjugating Enzyme Binding Signaling Receptor Activity Sequence-specific DNA Binding Protein-containing Complex Binding Metal Ion Binding NFAT Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding MDM2/MDM4 Family Protein Binding DNA-binding Transcription Factor Binding	Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Gluconeogenesis Regulation Of DNA-templated Transcription Lipid Metabolic Process Fatty Acid Metabolic Process Heart Development Response To Nutrient Lactation Epidermis Development Cellular Response To Starvation Hormone-mediated Signaling Pathway Gene Expression Regulation Of Gene Expression Regulation Of Ketone Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Cholesterol Storage Regulation Of Fatty Acid Metabolic Process Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Appetite Response To Insulin Circadian Regulation Of Gene Expression Behavioral Response To Nicotine Peroxisome Proliferator Activated Receptor Signaling Pathway Wound Healing Lipoprotein Metabolic Process Regulation Of Circadian Rhythm Response To Ethanol Positive Regulation Of Gluconeogenesis Negative Regulation Of Blood Pressure Negative Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nitric Oxide Metabolic Process Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Lipid Biosynthetic Process Rhythmic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Enamel Mineralization Cellular Response To Fructose Stimulus Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of MiRNA Transcription Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Transformation Of Host Cell By Virus Regulation Of Fatty Acid Transport Positive Regulation Of ATP Biosynthetic Process	Skeletal Muscle Contraction Neuromuscular Synaptic Transmission Skeletal Muscle Fiber Development Positive Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha SUMOylation of intracellular receptors Cytoprotection by HMOX1 Heme signaling Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs		alpha-Linolenic acid Icosapent Troglitazone Valproic acid Indomethacin Rosiglitazone Fenoprofen Clofibrate Fenofibrate Ibuprofen Amiodarone Gemfibrozil Bezafibrate Prasterone N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide Flufenamic acid Resveratrol Phthalic Acid Lauric acid Stearic acid Doconexent Palmitic Acid Oleic Acid Caprylic acid Arachidonic Acid Reglitazar Elafibranor Cardarine Muraglitazar Ertiprotafib Ragaglitazar Tesaglitazar GW-590735 Indeglitazar Myristic acid Aleglitazar Clinofibrate Ciprofibrate Dexibuprofen Soybean oil Omega-3 fatty acids Myrrh Isoflavone Leukotriene B4 Fenofibric acid Fish oil
Diseases
GWAS		Cholesterol, total ( 24097068) CTACK levels ( 27989323) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Impulsivity (motor) ( 30718321) LDL cholesterol ( 24097068) Liver enzyme levels (alkaline phosphatase) ( 33972514) Refractive error ( 32231278) Resting-state electroencephalogram vigilance ( 29703947) Triglyceride levels ( 32203549) Type 2 diabetes ( 31049640) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Glycated hemoglobin levels ( 34059833) Schizophrenia ( 25056061 29483656)
Interacting Genes		70 interacting genes: AIP AKAP13 ANKRD11 AQP1 BCL2 CCDC179 CDC34 CDK3 CEP350 CHD9 CHIC2 COL8A1 CTNNA3 DAP3 DUT EP300 EXOSC4 FABP1 FAM90A1 FAM9B FBLN1 FOXA3 GADD45A GADD45B GADD45G GPANK1 HELZ2 HOXC8 HSP90AA1 KCTD7 KRTAP10-1 LAMTOR5 MAPK1 MAPK3 MECR MED1 MED24 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR1H2 NR1H3 NRBF2 NRIP1 PAQR3 PICK1 PIK3R3 POU1F1 PPARGC1A PPARGC1B PRKCA PRKCD PRMT1 PRMT8 RELA RXRA RXRG SDCBP SIRT1 STAC3 TNP1 TRIM55 TRIM63 UBE2I VWA5A VWC2L ZNF587 ZSCAN23	38 interacting genes: ANKRD36 BAZ2B C1orf35 CSNK2A1 DIP2A DRC4 EAF1 EAF2 ENKD1 FAM124A FAM133A FAM90A1 FAM9A FGF11 FGF12 GIGYF1 GRB7 HMGXB4 INO80B JMJD6 L3MBTL2 MAB21L3 MFAP1 NKAPD1 NSD3 PPARA RPL22 RPL9 RPS25 SPANXN2 SPANXN3 SREK1IP1 TCEA2 TNFAIP8L1 U2AF2 VCX2 ZCCHC10 ZGPAT
Entrez ID		5465	246329
HPRD ID		01369	11606
Ensembl ID		ENSG00000186951	ENSG00000185482
Uniprot IDs		F1D8S4 Q07869	Q96MF2
PDB IDs		1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK 6KAX 6KAY 6KAZ 6KB0 6KB1 6KB2 6KB3 6KB4 6KB5 6KB6 6KB7 6KB8 6KB9 6KBA 6KXX 6KXY 6KYP 6L36 6L37 6L38 6L96 6LX4 6LX5 6LX6 6LX7 6LX8 6LX9 6LXA 6LXB 6LXC 7BPY 7BPZ 7BQ0 7BQ1 7BQ2 7BQ3 7BQ4 7C6Q 7E5F 7E5G 7E5H 7E5I 8HUK 8HUN 8HUQ 8RCE	2DB6 6B29 6UY7 6UY8 6UY9
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Binding Nucleoplasm Nuclear Receptor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Nucleus Transcription Coactivator Activity Intracellular Receptor Signaling Pathway Transcription Coregulator Activity Intracellular Signal Transduction Hormone-mediated Signaling Pathway Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process MRNA Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Response To Lipid Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II MRNA Transcription Response To Hormone Chromatin Response To Steroid Hormone Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nuclear Retinoic Acid Receptor Binding Response To Nutrient Levels Regulation Of Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Retinoid X Receptor Binding Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Cellular Response To Nutrient Levels Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cholesterol Efflux Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Chromatin DNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Lipid Metabolic Process Regulation Of Primary Metabolic Process Nucleobase-containing Compound Biosynthetic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Transcription By RNA Polymerase II Response To Starvation	Transcription Elongation Factor Complex Super Elongation Complex Transcription Elongation By RNA Polymerase II Transcription Elongation Factor Activity DNA-templated Transcription Elongation Transcription Regulator Activator Activity
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