PPARA and FOXA3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PPARA	FOXA3
Gene Name		peroxisome proliferator-activated receptor alpha	forkhead box A3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Repressing Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Drug Binding Zinc Ion Binding Lipid Binding Phosphatase Binding Protein Domain Specific Binding Ubiquitin Conjugating Enzyme Binding Protein Complex Binding Sequence-specific DNA Binding NFAT Protein Binding MDM2/MDM4 Family Protein Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Protein Domain Specific Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Fatty Acid Metabolic Process Heart Development Circadian Rhythm Epidermis Development Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Cholesterol Storage Negative Regulation Of Sequestering Of Triglyceride Fatty Acid Transport Intracellular Receptor Signaling Pathway Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Protein Binding Negative Regulation Of Appetite Response To Insulin Circadian Regulation Of Gene Expression Behavioral Response To Nicotine Wound Healing Lipoprotein Metabolic Process Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Gluconeogenesis Negative Regulation Of Blood Pressure Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fatty Acid Oxidation Enamel Mineralization Regulation Of Glycolytic By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Neuron Death Negative Regulation Of Transcription Regulatory Region DNA Binding	Cellular Glucose Homeostasis Transcription From RNA Polymerase II Promoter Spermatogenesis Cellular Response To Starvation Chromatin Modification Cell Differentiation Endocrine Pancreas Development Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Nuclear Receptor transcription pathway REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters	Regulation of beta-cell development Regulation of gene expression in beta cells
Drugs		Clofibrate Fenofibrate Gemfibrozil Bezafibrate Deoxy-Bigchap 2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid ALEGLITAZAR
Diseases
GWAS
Protein-Protein Interactions		44 interactors: AIP AKAP13 CDK3 CEP350 CHD9 DAP3 DUT EP300 FABP1 FOXA3 GADD45A GADD45B GADD45G HELZ2 HSP90AA1 MAPK1 MAPK3 MECR MED1 MED24 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR1H3 NRBF2 NRIP1 POU1F1 PPARGC1A PPARGC1B PRKCA PRKCD PRMT1 PRMT8 RELA RXRA RXRG SIRT1 SRC STAC3 SUMO1 TNP1 UBE2I	5 interactors: ALX4 HMGB1 PPARA TLE1 TLE2
Entrez ID		5465	3171
HPRD ID		01369	03802
Ensembl ID		ENSG00000186951	ENSG00000170608
Uniprot IDs		F1D8S4 Q07869	P55318
PDB IDs		1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR	1VTN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Transcription, DNA-templated Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Response To Hormone DNA-templated Transcription, Initiation Organelle Organization Regulation Of Gene Expression Cellular Response To Organic Substance Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Chromatin Modification Negative Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Regulation Of Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Response To Organic Substance Peptidyl-amino Acid Modification Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Androgen Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Regulation Of Signaling Signal Transduction Response To Steroid Hormone Negative Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Cell Communication Nucleobase-containing Compound Metabolic Process	Organ Morphogenesis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Regulation Of DNA Binding Regulation Of Transcription From RNA Polymerase II Promoter System Development Regulation Of Transcription, DNA-templated Regulation Of Glycolytic By Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Apoptotic Cell Clearance Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Notch Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Anatomical Structure Development Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Anatomical Structure Morphogenesis Negative Regulation Of Wnt Signaling Pathway Developmental Process Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Base-excision Repair, DNA Ligation Regulation Of Binding Organ Development Negative Regulation Of Receptor Biosynthetic Process Epidermis Development Wnt Signaling Pathway Behavioral Response To Nicotine Enamel Mineralization RNA Metabolic Process Negative Regulation Of Sequestering Of Triglyceride Negative Regulation Of Cholesterol Storage
Tagcloud ?		abca1 alfalfa aragonesa breed concentrate contrary dams finishing grazed grazing indoors lambs lengths lpl lt pparg rasa scarb1 sf slaughtering srebp1 subcutaneous supplemented thoracis tocopherol tocopheryl ve10d ve20d ve30d	cancerous cb chinese counterparts csf1r ctnnb1 drastic functionally genotyped hbv hcc hot jak1 livers mafg nras oncogenes onecut1 option pik3ca sixth smo spot ssx1 suppressors threat transcriptomes transcriptomic valid
Tagcloud (Difference) ?		abca1 alfalfa aragonesa breed concentrate contrary dams finishing grazed grazing indoors lambs lengths lpl lt pparg rasa scarb1 sf slaughtering srebp1 subcutaneous supplemented thoracis tocopherol tocopheryl ve10d ve20d ve30d	cancerous cb chinese counterparts csf1r ctnnb1 drastic functionally genotyped hbv hcc hot jak1 livers mafg nras oncogenes onecut1 option pik3ca sixth smo spot ssx1 suppressors threat transcriptomes transcriptomic valid
Tagcloud (Intersection) ?