UCP1 and CIDEA

Number of citations of the paper that reports this interaction (PubMedID 12910269)
0

Data Source:
HPRD (in vitro)

		UCP1	CIDEA
Description		uncoupling protein 1	cell death inducing DFFA like effector a
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Envelope Mitochondrial Inner Membrane Membrane	Nucleus Cytoplasm Mitochondrion Mitochondrial Envelope Lipid Droplet Cytosol
	Molecular Function	Protein Binding GTP Binding Proton Transmembrane Transporter Activity Oxidative Phosphorylation Uncoupler Activity GDP Binding Transmembrane Transporter Activity Purine Ribonucleotide Binding Long-chain Fatty Acid Binding Anion Binding Cardiolipin Binding	Protein Homodimerization Activity Phosphatidic Acid Binding Lipid Transfer Activity
	Biological Process	Diet Induced Thermogenesis Regulation Of Transcription By RNA Polymerase II Monoatomic Ion Transport Mitochondrial Transport Response To Temperature Stimulus Response To Cold Response To Nutrient Levels Cellular Response To Hormone Stimulus Monoatomic Ion Transmembrane Transport Cellular Response To Reactive Oxygen Species Brown Fat Cell Differentiation Transmembrane Transport Cellular Response To Cold Cellular Response To Fatty Acid Positive Regulation Of Cold-induced Thermogenesis Proton Transmembrane Transport Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Dehydroepiandrosterone Mitochondrial Transmembrane Transport Adaptive Thermogenesis	Temperature Homeostasis Negative Regulation Of Cytokine Production Lipid Metabolic Process Apoptotic Process Lipid Storage Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Production Response To Stilbenoid Fat Cell Differentiation Negative Regulation Of Lipid Catabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Cellular Response To Cold Intermembrane Lipid Transfer Negative Regulation Of Cold-induced Thermogenesis Lipid Droplet Fusion Negative Regulation Of Execution Phase Of Apoptosis Regulation Of Apoptotic DNA Fragmentation
Pathways		Mitochondrial Uncoupling The fatty acid cycling model Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Lipid particle organization Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Drugs
Diseases
GWAS		Malaria ( 31844061)	Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297)
Interacting Genes		2 interacting genes: CIDEA TOMM20	5 interacting genes: CIDEB CIDEC MIEF2 UCP1 ZBTB16
Entrez ID		7350	1149
HPRD ID		00221	08380
Ensembl ID		ENSG00000109424	ENSG00000176194
Uniprot IDs		P25874 Q4KMT7	B3KVA2 O60543 Q8N5P9
PDB IDs		8G8W 8HBV 8HBW 8J1N	2EEL
Enriched GO Terms of Interacting Partners?		Mitochondrial Envelope Protein-transporting ATPase Activity TRNA Import Into Mitochondrion Regulation Of Apoptotic DNA Fragmentation Response To Stilbenoid Lipid Droplet Fusion Negative Regulation Of Execution Phase Of Apoptosis TRNA Transport Mitochondrial Outer Membrane Translocase Complex RNA Import Into Mitochondrion TOM Complex Mitochondrion Targeting Sequence Binding Migrasome Membrane Organization Lipid Transfer Activity Protein Insertion Into Mitochondrial Outer Membrane Cellular Response To Cold Phosphatidic Acid Binding Negative Regulation Of Lipid Catabolic Process Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Protein Import Into Mitochondrial Matrix Protein Targeting To Mitochondrion Protein Transmembrane Transporter Activity Intermembrane Lipid Transfer Temperature Homeostasis Lipid Storage Establishment Of Protein Localization To Mitochondrial Membrane Protein Insertion Into Mitochondrial Membrane Lipid Droplet Organization Response To Cold Protein Localization To Mitochondrion Negative Regulation Of Cold-induced Thermogenesis Sperm Midpiece Regulation Of Lipid Catabolic Process Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Protein Insertion Into Membrane Mitochondrion Protein Transmembrane Transport Establishment Of Protein Localization To Mitochondrion Lipid Droplet Cell Periphery Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Unfolded Protein Binding Mitochondrial Membrane Organization Fat Cell Differentiation Organelle Fusion Regulation Of Cold-induced Thermogenesis Response To Temperature Stimulus	Lipid Droplet Fusion Lipid Transfer Activity Organelle Fusion Execution Phase Of Apoptosis Phosphatidic Acid Binding Lipid Storage Intermembrane Lipid Transfer Regulation Of Triglyceride Metabolic Process Lipid Droplet Organization Cellular Response To Dehydroepiandrosterone Purine Ribonucleotide Binding Lipid Droplet Type 2 Angiotensin Receptor Binding Response To Dehydroepiandrosterone Male Germ-line Stem Cell Asymmetric Division Long-chain Fatty Acid Binding Oxidative Phosphorylation Uncoupler Activity Anion Binding Germ-line Stem Cell Division Cell Death Apoptotic Process Programmed Cell Death Positive Regulation Of NK T Cell Differentiation Regulation Of NK T Cell Differentiation Ossification Involved In Bone Maturation Diet Induced Thermogenesis Lipid Transport Very-low-density Lipoprotein Particle Assembly Cardiolipin Binding Regulation Of Lipid Metabolic Process Cellular Response To Cold Mesonephros Development Asymmetric Cell Division COPI-coated Vesicle Negative Regulation Of Triglyceride Metabolic Process Mitochondrial Envelope COPII Vesicle Coat COPII-coated Vesicle Cargo Loading Mitochondrial Fusion Positive Regulation Of Chondrocyte Differentiation Mitochondrial Transmembrane Transport Positive Regulation Of Mitochondrial Fission Adaptive Thermogenesis Plasma Lipoprotein Particle Assembly Proton Transmembrane Transporter Activity Stem Cell Division Protein-lipid Complex Assembly Negative Regulation Of Lipid Catabolic Process Response To Nutrient Levels Positive Regulation Of Protein Targeting To Membrane
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