UCP1

Name	uncoupling protein 1
Structure
Interactors	2 interactors: CIDEA TOMM20
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Envelope Mitochondrial Inner Membrane Membrane
	Molecular Function	Protein Binding GTP Binding Proton Transmembrane Transporter Activity Oxidative Phosphorylation Uncoupler Activity GDP Binding Transmembrane Transporter Activity Purine Ribonucleotide Binding Long-chain Fatty Acid Binding Anion Binding Cardiolipin Binding
	Biological Process	Diet Induced Thermogenesis Regulation Of Transcription By RNA Polymerase II Monoatomic Ion Transport Mitochondrial Transport Response To Temperature Stimulus Response To Cold Response To Nutrient Levels Cellular Response To Hormone Stimulus Monoatomic Ion Transmembrane Transport Cellular Response To Reactive Oxygen Species Brown Fat Cell Differentiation Transmembrane Transport Cellular Response To Cold Cellular Response To Fatty Acid Positive Regulation Of Cold-induced Thermogenesis Proton Transmembrane Transport Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Dehydroepiandrosterone Mitochondrial Transmembrane Transport Adaptive Thermogenesis
Pathways	Mitochondrial Uncoupling The fatty acid cycling model Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
GWAS	Malaria ( 31844061 )
Entrez ID	7350
HPRD ID	00221
Ensembl ID	ENSG00000109424
Uniprot IDs	P25874 Q4KMT7
PDB IDs	8G8W 8HBV 8HBW 8J1N
GO Terms Enriched among Interactors ?	Mitochondrial Envelope Protein-transporting ATPase Activity TRNA Import Into Mitochondrion Regulation Of Apoptotic DNA Fragmentation Response To Stilbenoid Lipid Droplet Fusion Negative Regulation Of Execution Phase Of Apoptosis TRNA Transport Mitochondrial Outer Membrane Translocase Complex RNA Import Into Mitochondrion TOM Complex Mitochondrion Targeting Sequence Binding Migrasome Membrane Organization Lipid Transfer Activity Protein Insertion Into Mitochondrial Outer Membrane Cellular Response To Cold Phosphatidic Acid Binding Negative Regulation Of Lipid Catabolic Process Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Protein Import Into Mitochondrial Matrix Protein Targeting To Mitochondrion Protein Transmembrane Transporter Activity Intermembrane Lipid Transfer Temperature Homeostasis Lipid Storage Establishment Of Protein Localization To Mitochondrial Membrane Protein Insertion Into Mitochondrial Membrane Lipid Droplet Organization Response To Cold Protein Localization To Mitochondrion Negative Regulation Of Cold-induced Thermogenesis Sperm Midpiece Regulation Of Lipid Catabolic Process Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Protein Insertion Into Membrane Mitochondrion Protein Transmembrane Transport Establishment Of Protein Localization To Mitochondrion Lipid Droplet Cell Periphery Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Unfolded Protein Binding Mitochondrial Membrane Organization Fat Cell Differentiation Organelle Fusion Regulation Of Cold-induced Thermogenesis Response To Temperature Stimulus