UCP1

Gene Name		uncoupling protein 1 (mitochondrial, proton carrier)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane
	Molecular Function	Oxidative Phosphorylation Uncoupler Activity
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Mitochondrial Transport Proton Transport Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process Brown Fat Cell Differentiation
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. The proton buffering model Mitochondrial Uncoupling Proteins The fatty acid cycling model The citric acid (TCA) cycle and respiratory electron transport
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: CIDEA TOMM20
Entrez ID		7350
HPRD ID		00221
Ensembl ID
Uniprot IDs		P25874 Q4KMT7
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Sequestering Of Triglyceride Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Execution Phase Of Apoptosis Response To Stilbenoid Negative Regulation Of Lipid Catabolic Process Temperature Homeostasis Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Lipid Storage Negative Regulation Of Cytokine Secretion Lipid Storage Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Lipid Catabolic Process Regulation Of Lipid Storage Protein Transmembrane Transport Protein Targeting To Mitochondrion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization To Mitochondrion Negative Regulation Of Lipid Metabolic Process Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Protein Secretion Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cytokine Secretion
Tagcloud ?		1s adipocyte adipose ap2 bip carbonylation chop concomitant enigmatic equilibrium fabp fabp4 fatty ffa herein hts01037 indirectly lipopolysaccharide macrophages negated null palmitate pharmacologic r126q ucp2 ucp3 uncouples uncoupling xbp