UCP1 and TOMM20

Number of citations of the paper that reports this interaction (PMID 9119086)
5

Data Source:
HPRD (in vitro)

		UCP1	TOMM20
Gene Name		uncoupling protein 1 (mitochondrial, proton carrier)	translocase of outer mitochondrial membrane 20 homolog (yeast)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane	Mitochondrion Mitochondrial Outer Membrane Translocase Complex Integral Component Of Membrane ER-mitochondrion Membrane Contact Site
	Molecular Function	Oxidative Phosphorylation Uncoupler Activity	Protein Binding P-P-bond-hydrolysis-driven Protein Transmembrane Transporter Activity Unfolded Protein Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Mitochondrial Transport Proton Transport Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process Brown Fat Cell Differentiation	Protein Targeting To Mitochondrion Cellular Protein Metabolic Process Protein Transmembrane Transport
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. The proton buffering model Mitochondrial Uncoupling Proteins The fatty acid cycling model The citric acid (TCA) cycle and respiratory electron transport	Mitochondrial protein import
Drugs
Diseases
GWAS			Cholesterol, total ( 20686565) Immune reponse to smallpox (secreted IL-2) ( 22610502) LDL cholesterol ( 20686565) Obesity-related traits ( 23251661)
Protein-Protein Interactions		2 interactors: CIDEA TOMM20	17 interactors: AIP APOA1 ATXN1 BAG6 BCL2 CDC73 DHFR FEZ1 HAP1 KIAA1377 OTC PPHLN1 PTN TOMM22 TOMM40 UCP1 VDAC1
Entrez ID		7350	9804
HPRD ID		00221	03507
Ensembl ID			ENSG00000173726
Uniprot IDs		P25874 Q4KMT7	Q15388
PDB IDs			4APO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Sequestering Of Triglyceride Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Execution Phase Of Apoptosis Response To Stilbenoid Negative Regulation Of Lipid Catabolic Process Temperature Homeostasis Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Lipid Storage Negative Regulation Of Cytokine Secretion Lipid Storage Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Lipid Catabolic Process Regulation Of Lipid Storage Protein Transmembrane Transport Protein Targeting To Mitochondrion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization To Mitochondrion Negative Regulation Of Lipid Metabolic Process Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Protein Secretion Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cytokine Secretion	Mitochondrial Transport Cellular Localization Regulation Of Protein Stability Establishment Of Localization In Cell Developmental Process Anatomical Structure Development Posttranscriptional Regulation Of Gene Expression Protein Targeting To Mitochondrion Protein Localization To Mitochondrion Intracellular Transport Transport Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Learning Mitochondrion Organization Regulation Of Mitotic Cell Cycle Cell Differentiation Cell Cycle Single-organism Behavior Negative Regulation Of Autophagy Response To Organic Cyclic Compound Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Behavioral Fear Response Regulation Of Cell Cycle Process Positive Regulation Of Cell Development Fear Response Protein Localization To Organelle Response To Drug Axon Regeneration Regulation Of Smooth Muscle Cell Migration Multicellular Organismal Development Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Anion Homeostasis Organ Development Regulation Of Cell Cycle Phase Transition Neuron Projection Regeneration Behavior Organelle Organization Ornithine Catabolic Process Negative Regulation Of Cellular PH Reduction Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Cell Adhesion Molecule Production Learning Or Memory Protein Transmembrane Transport System Development Mitochondrial Membrane Organization
Tagcloud ?		1s adipocyte adipose ap2 bip carbonylation chop concomitant enigmatic equilibrium fabp fabp4 fatty ffa herein hts01037 indirectly lipopolysaccharide macrophages negated null palmitate pharmacologic r126q ucp2 ucp3 uncouples uncoupling xbp
Tagcloud (Difference) ?		1s adipocyte adipose ap2 bip carbonylation chop concomitant enigmatic equilibrium fabp fabp4 fatty ffa herein hts01037 indirectly lipopolysaccharide macrophages negated null palmitate pharmacologic r126q ucp2 ucp3 uncouples uncoupling xbp
Tagcloud (Intersection) ?