BCL2 and FKBP8

Number of citations of the paper that reports this interaction (PMID 12510191)
50

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		BCL2	FKBP8
Gene Name		B-cell CLL/lymphoma 2	FK506 binding protein 8, 38kDa
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Nuclear Membrane Myelin Sheath Pore Complex	Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane Mitochondrial Membrane
	Molecular Function	Protease Binding Protein Binding Transcription Factor Binding Channel Activity Channel Inhibitor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity BH3 Domain Binding Protein Phosphatase 2A Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Ossification Ovarian Follicle Development Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Behavioral Fear Response B Cell Homeostasis Release Of Cytochrome C From Mitochondria Regulation Of Cell-matrix Adhesion Lymphoid Progenitor Cell Differentiation B Cell Lineage Commitment Response To Ischemia Renal System Process Protein Dephosphorylation Melanin Metabolic Process Regulation Of Nitrogen Utilization Apoptotic Process Humoral Immune Response Cellular Response To DNA Damage Stimulus Actin Filament Organization Axonogenesis Female Pregnancy Cell Aging Male Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Radiation Response To Toxic Substance Post-embryonic Development Response To Iron Ion Response To UV-B Response To Gamma Radiation Negative Regulation Of Autophagy Negative Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Glycoprotein Biosynthetic Process Mesenchymal Cell Development Positive Regulation Of Neuron Maturation Positive Regulation Of Smooth Muscle Cell Migration Cell Growth Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cochlear Nucleus Development Gland Morphogenesis Regulation Of Transmembrane Transporter Activity Negative Regulation Of Ossification Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Melanocyte Differentiation Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Hair Follicle Morphogenesis Axon Regeneration Regulation Of Protein Stability Endoplasmic Reticulum Calcium Ion Homeostasis Glomerulus Development Negative Regulation Of Cellular PH Reduction Negative Regulation Of Myeloid Cell Apoptotic Process T Cell Differentiation In Thymus Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Osteoblast Proliferation Response To Cytokine Response To Nicotine Organ Growth Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Multicellular Organism Growth B Cell Proliferation Cellular Response To Glucose Starvation Response To Drug Response To Hydrogen Peroxide T Cell Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Protein Homodimerization Activity Regulation Of Protein Heterodimerization Activity Negative Regulation Of Neuron Apoptotic Process Ear Development Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Melanocyte Differentiation Negative Regulation Of Retinal Cell Programmed Cell Death Regulation Of Mitochondrial Membrane Permeability Focal Adhesion Assembly Spleen Development Thymus Development Digestive Tract Morphogenesis Developmental Growth Oocyte Development Positive Regulation Of Skeletal Muscle Fiber Development Pigment Granule Organization Homeostasis Of Number Of Cells Within A Tissue B Cell Receptor Signaling Pathway Response To Glucocorticoid Neuron Apoptotic Process Defense Response To Virus Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Mitochondrial Depolarization Regulation Of Calcium Ion Transport Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Organic Substance Cellular Response To Hypoxia Reactive Oxygen Species Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Anoikis Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Protein Peptidyl-prolyl Isomerization Cell Fate Specification Apoptotic Process Smoothened Signaling Pathway Regulation Of Gene Expression Viral Process Dorsal/ventral Neural Tube Patterning Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intracellular Signal Transduction Camera-type Eye Development Negative Regulation Of Apoptotic Process Chaperone-mediated Protein Folding
Pathways		Activation of BAD and translocation to mitochondria Inflammasomes The NLRP1 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Programmed Cell Death Activation of BH3-only proteins BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Innate Immune System Intrinsic Pathway for Apoptosis
Drugs		Ibuprofen Paclitaxel Docetaxel Rasagiline
Diseases
GWAS		Cardiac Troponin-T levels ( 23247143)
Protein-Protein Interactions		83 interactors: ATP2A2 BAD BAG1 BAG3 BAG4 BAK1 BAX BBC3 BCAP31 BCL2L1 BCL2L10 BCL2L11 BCL2L14 BCLAF1 BECN1 BFAR BID BIK BLK BMF BNIP1 BNIP2 BNIP3 BNIP3L BNIPL CAPN2 CASP3 CASP8 CDK1 CDK2 CPT1A CYCS EPHB2 FKBP8 HNRNPD HRAS HRK HSPA1A ITM2B ITPR1 KRAS MAPK1 MAPK11 MAPK14 MAPK3 MAPK8 MEX3D MOAP1 MYC NLRP1 NMT2 NR4A1 NRAS PARP1 PIN1 PKMYT1 PMAIP1 PML PPID PPP1CA PPP2CA PPP2R4 PPP2R5A PPP3CA PPP3CC PRKACA PRKCA PSEN1 PXN RAD9A RAF1 RRAS RTN4 SF1 SMN1 SOD1 SPNS1 SQSTM1 TMBIM6 TOMM20 TP53 TP53AIP1 TP53BP2	15 interactors: ARHGEF5 ATP13A2 BCL2 BCL2L1 BNIPL EGFR EGLN1 MAPK14 MTOR PPP3CA PSMC1 PSMD2 RHEB TERF1 VHL
Entrez ID		596	23770
HPRD ID		01045	05327
Ensembl ID		ENSG00000171791	ENSG00000105701
Uniprot IDs		C9JHD5 P10415	J3KQ73 Q14318
PDB IDs		1G5M 1GJH 1YSW 2O21 2O22 2O2F 2W3L 2XA0 4AQ3 4IEH 4LVT 4LXD 4LXE	2AWG 2D9F 2F2D 2JWX 3EY6
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Mitochondrion Organization Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Mitochondrion Organization Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Death Negative Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Response To Growth Factor Signal Transduction Cell Communication Response To Abiotic Stimulus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Signaling Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Apoptotic Mitochondrial Changes Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Cellular Component Organization Response To Stress Regulation Of Catalytic Activity Cellular Response To Organic Substance Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability	Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Intracellular Signal Transduction Cell Cycle Process Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Response To Organonitrogen Compound Positive Regulation Of Signal Transduction Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Cellular Response To Oxygen Levels Regulation Of Cell Cycle Positive Regulation Of Myotube Differentiation Negative Regulation Of Autophagy Cellular Response To Stress Immune System Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Response To Abiotic Stimulus Regulation Of Establishment Of Protein Localization Mitotic Cell Cycle Process Regulation Of Signaling G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Regulation Of Catalytic Activity Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Import Into Nucleus Negative Regulation Of Signaling Cellular Response To Stimulus Response To Stimulus Mitotic Cell Cycle Regulation Of Protein Localization Regulation Of Intracellular Transport Regulation Of Protein Localization To Nucleus Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Myotube Differentiation Response To Stress Positive Regulation Of Striated Muscle Cell Differentiation Immune Response-regulating Signaling Pathway Cellular Response To DNA Damage Stimulus Regulation Of Nucleocytoplasmic Transport Response To Inorganic Substance Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Ketone Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Modification Process
Tagcloud ?		adenocarcinomas anthracene carcinogenic chorionic dawley dimethylbenz dmba elevation exists glands gonadotropin hcg ice iu makes mammary modulated myc ovaries phenomenon probed programmed rnas sprague trpm2 virgin xl xs	e9 exacerbating fibrillary folate folic gfap gliogenesis h3k27me3 lumbar lys27 message msx2 neural neurogenesis neurospheres nkx6 noggin nonresponsive nonresponsiveness o4 olig2 oligodendrocyte oligodendrogenesis tetratricopeptide tube tuj1 ubiquitously utx ventralization
Tagcloud (Difference) ?		adenocarcinomas anthracene carcinogenic chorionic dawley dimethylbenz dmba elevation exists glands gonadotropin hcg ice iu makes mammary modulated myc ovaries phenomenon probed programmed rnas sprague trpm2 virgin xl xs	e9 exacerbating fibrillary folate folic gfap gliogenesis h3k27me3 lumbar lys27 message msx2 neural neurogenesis neurospheres nkx6 noggin nonresponsive nonresponsiveness o4 olig2 oligodendrocyte oligodendrogenesis tetratricopeptide tube tuj1 ubiquitously utx ventralization
Tagcloud (Intersection) ?