PPP4C and TMSB4X

Number of citations of the paper that reports this interaction (PubMedID 9647778)
0

Data Source:
HPRD (two hybrid, in vitro)

		PPP4C	TMSB4X
Description		protein phosphatase 4 catalytic subunit	thymosin beta 4 X-linked
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Protein Phosphatase 4 Complex	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Platelet Alpha Granule Lumen
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding	RNA Binding Actin Binding Actin Monomer Binding Actin Monomer Sequestering Activity Protein Binding Enzyme Binding Protein Sequestering Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Actin Filament Organization Regulation Of Cell Migration Negative Regulation Of Actin Filament Polymerization Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Inflammatory Response Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Proton-transporting ATP Synthase Activity, Rotational Mechanism Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of ATP Biosynthetic Process
Pathways		Processing of DNA double-strand break ends	Platelet degranulation
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Eosinophil percentage of white cells ( 32888494) Mean corpuscular volume ( 29403010) Medication use (diuretics) ( 31015401) Schizophrenia ( 25056061 29483656)	Asthma ( 30929738) Asthma (childhood onset) ( 30929738)
Interacting Genes		21 interacting genes: CCDC6 DHX38 GPANK1 HDAC3 IGBP1 JUN NFKB1 PPP2R1A PPP2R5D PPP4R1 PPP4R2 PPP4R3B PPP4R4 REL RELA TIPRL TK1 TMSB4X TP53 TRAF6 UBE2D3	38 interacting genes: ACTA1 ACTA2 ACTB ACTG1 AKAP8L ALAS1 ANXA7 APLP1 CDKN1A COG6 FAM118B FHL3 GOLGA6L9 GRB7 HSF2BP IGSF21 ILK KRT13 KRT15 KRT31 KRT34 KRT36 KRT40 KRTAP8-1 LIMS1 PNMA1 PPP4C RAD21 RBPMS SCHIP1 SMN1 TAF1D TGM2 TK1 TRIM23 TRIM27 TRIP6 UHMK1
Entrez ID		5531	7114
HPRD ID		03615	02153
Ensembl ID		ENSG00000149923	ENSG00000205542
Uniprot IDs		A0A024R625 P60510	A2VCK8 P62328 Q0P5T0
PDB IDs			3TU5 4PL7 4PL8
Enriched GO Terms of Interacting Partners?		Protein Phosphatase Regulator Activity Tumor Necrosis Factor-mediated Signaling Pathway Protein Phosphatase 4 Complex Non-canonical NF-kappaB Signal Transduction General Transcription Initiation Factor Binding Canonical NF-kappaB Signal Transduction Positive Regulation Of MiRNA Metabolic Process NF-kappaB P50/p65 Complex Protein Phosphatase Activator Activity Chromatin Response To Muscle Stretch Regulation Of MiRNA Metabolic Process Enzyme Binding NF-kappaB Complex DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Binding Transcription Coactivator Binding Cellular Response To Nicotine Positive Regulation Of MiRNA Transcription Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Transcription Repressor Complex Regulation Of Interleukin-12 Production Meiotic Sister Chromatid Cohesion Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Mechanical Stimulus Positive Regulation Of DNA-templated Transcription Initiation Regulation Of MiRNA Transcription Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Response To Interleukin-1 Regulation Of DNA-templated Transcription Initiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Metabolic Process Actinin Binding Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Cellular Response To Angiotensin Cellular Response To Interleukin-6 Protein Phosphatase Type 2A Complex Cytosol Transcription Regulator Complex Cytoplasm Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Chromatin Binding Transcription Cis-regulatory Region Binding	Morphogenesis Of An Epithelium Structural Constituent Of Skin Epidermis Tissue Morphogenesis Intermediate Filament Organization Intermediate Filament Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cytoskeleton Epithelial Cell Differentiation Structural Constituent Of Cytoskeleton Cytosol Structural Molecule Activity Focal Adhesion Supramolecular Fiber Organization Regulation Of Transepithelial Transport Stress Fiber Cytoskeleton Organization Mesenchyme Migration Dense Body Protein Kinase Binding Identical Protein Binding Developmental Process Morphogenesis Of A Polarized Epithelium Structural Constituent Of Postsynaptic Actin Cytoskeleton Platelet Aggregation Organelle Organization Anatomical Structure Morphogenesis Epidermis Development Actin Cytoskeleton Homotypic Cell-cell Adhesion Postsynaptic Actin Cytoskeleton Organization Cellular Response To Catecholamine Stimulus Lamellipodium Protein Localization To Cell-cell Junction Calyx Of Held Response To Catecholamine Actin Filament Postsynaptic Cytoskeleton Organization Protein Binding Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Hepatic Stellate Cell Contraction Apical Junction Complex NuA4 Histone Acetyltransferase Complex Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Synaptic Vesicle Recycling Basal Body Patch Alpha-2B Adrenergic Receptor Binding Peptide Dopaminyltransferase Activity
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