PPP4C and CCDC6

Number of citations of the paper that reports this interaction (PMID 17353931)
246

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		PPP4C	CCDC6
Gene Name		protein phosphatase 4, catalytic subunit	coiled-coil domain containing 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Plasma Membrane Protein Phosphatase 4 Complex	Cytoplasm Cytoskeleton
	Molecular Function	NF-kappaB-inducing Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding	Structural Constituent Of Cytoskeleton Protein Binding SH3 Domain Binding
	Biological Process	Regulation Of Double-strand Break Repair Via Homologous Recombination Dephosphorylation NIK/NF-kappaB Signaling	Biological_process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: CCDC6 DHX38 HDAC3 IGBP1 JUN NFKB1 PPP2R1A PPP2R5D PPP4R1 PPP4R2 PPP4R4 REL RELA SMEK2 TIPRL TK1 TMSB4X TP53 TRAF6 TRIM28	5 interactors: ATF2 CREB1 CSNK2A1 MAPK3 PPP4C
Entrez ID		5531	8030
HPRD ID		03615	09064
Ensembl ID		ENSG00000149923	ENSG00000108091
Uniprot IDs		P60510	Q05CP8 Q16204
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-12 Biosynthetic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor 4 Signaling Pathway Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Metabolic Process Response To Growth Factor Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-12 Biosynthetic Process NIK/NF-kappaB Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Transcription, DNA-templated Activation Of Innate Immune Response Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Interleukin-12 Production Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Innate Immune Response Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Death Regulation Of Catalytic Activity Response To Interleukin-1 Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin Signaling Pathway Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Innate Immune Response Positive Regulation Of Gene Expression Regulation Of Cell Death Regulation Of Cytokine Biosynthetic Process Innate Immune Response Immune System Process Membrane Protein Proteolysis Transcription From RNA Polymerase II Promoter Immune Response	Signal Transduction By Phosphorylation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Phosphorylation Positive Regulation Of Innate Immune Response MAPK Cascade Regulation Of Innate Immune Response Phosphate-containing Compound Metabolic Process Axon Guidance Protein Phosphorylation Cellular Protein Modification Process Immune Response-regulating Signaling Pathway Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Intracellular Signal Transduction Neuron Projection Morphogenesis Positive Regulation Of Immune Response Negative Regulation Of Apolipoprotein Binding Cellular Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Innate Immune Response Neuron Projection Development Positive Regulation Of Transforming Growth Factor Beta2 Production Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Cell Projection Morphogenesis Cell Part Morphogenesis Mitotic Cell Cycle Checkpoint Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune Response ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway RNA Biosynthetic Process
Tagcloud ?		6j acpp canonical carcinogenic cdk5 delineate e2f6 elf1 glands gprc5a hindered ingenuity ionizing ipa map2 mapk12 mapped microarray nab2 persistently perturbed plcg1 radiation runx1 scarcity sema4d stathmin1 surgically undertook	actionable adenocarcinomas akt1 alk braf capture cd74 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Difference) ?		6j acpp canonical carcinogenic cdk5 delineate e2f6 elf1 glands gprc5a hindered ingenuity ionizing ipa map2 mapk12 mapped microarray nab2 persistently perturbed plcg1 radiation runx1 scarcity sema4d stathmin1 surgically undertook	actionable adenocarcinomas akt1 alk braf capture cd74 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Intersection) ?