PPP4C and PPP4R4

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology), HPRD (in vivo)

		PPP4C	PPP4R4
Name		protein phosphatase 4 catalytic subunit	protein phosphatase 4 regulatory subunit 4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Protein Phosphatase 4 Complex	Cytoplasm Cytosol Cilium Protein Serine/threonine Phosphatase Complex Ciliary Basal Body
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding	Protein Phosphatase Inhibitor Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Regulator Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Blastocyst Hatching
Pathways		Processing of DNA double-strand break ends	None
GWAS		Adventurousness ( 30643258 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Body fat distribution (arm fat ratio) ( 30664634 ) Brain morphology (MOSTest) ( 32665545 ) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Eosinophil percentage of white cells ( 32888494 ) Mean corpuscular volume ( 29403010 ) Medication use (diuretics) ( 31015401 ) Schizophrenia ( 25056061 29483656 )	Chronic obstructive pulmonary disease ( 28166215 ) Post bronchodilator FEV1 ( 26634245 ) Post bronchodilator FEV1/FVC ratio ( 26634245 )
Interacting Genes		21 interacting genes: CCDC6 DHX38 GPANK1 HDAC3 IGBP1 JUN NFKB1 PPP2R1A PPP2R5D PPP4R1 PPP4R2 PPP4R3B PPP4R4 REL RELA TIPRL TK1 TMSB4X TP53 TRAF6 UBE2D3	1 interacting genes: PPP4C
Entrez ID		5531	57718
HPRD ID		03615	13878
Ensembl ID		ENSG00000149923	ENSG00000119698
Uniprot IDs		A0A024R625 P60510	Q6NUP7
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Protein Phosphatase Regulator Activity Tumor Necrosis Factor-mediated Signaling Pathway Protein Phosphatase 4 Complex Non-canonical NF-kappaB Signal Transduction General Transcription Initiation Factor Binding Canonical NF-kappaB Signal Transduction Positive Regulation Of MiRNA Metabolic Process NF-kappaB P50/p65 Complex Protein Phosphatase Activator Activity Chromatin Response To Muscle Stretch Regulation Of MiRNA Metabolic Process Enzyme Binding NF-kappaB Complex DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Binding Transcription Coactivator Binding Cellular Response To Nicotine Positive Regulation Of MiRNA Transcription Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Transcription Repressor Complex Regulation Of Interleukin-12 Production Meiotic Sister Chromatid Cohesion Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Mechanical Stimulus Positive Regulation Of DNA-templated Transcription Initiation Regulation Of MiRNA Transcription Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Response To Interleukin-1 Regulation Of DNA-templated Transcription Initiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Metabolic Process Actinin Binding Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Cellular Response To Angiotensin Cellular Response To Interleukin-6 Protein Phosphatase Type 2A Complex Cytosol Transcription Regulator Complex Cytoplasm Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Chromatin Binding Transcription Cis-regulatory Region Binding	Protein Phosphatase 4 Complex