PPP4C and DHX38

Number of citations of the paper that reports this interaction (PMID 18715871)
21

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		PPP4C	DHX38
Gene Name		protein phosphatase 4, catalytic subunit	DEAH (Asp-Glu-Ala-His) box polypeptide 38
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Plasma Membrane Protein Phosphatase 4 Complex	Nucleus Nucleoplasm Cytoplasm Membrane Catalytic Step 2 Spliceosome
	Molecular Function	NF-kappaB-inducing Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding	ATP-dependent RNA Helicase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Double-strand Break Repair Via Homologous Recombination Dephosphorylation NIK/NF-kappaB Signaling	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing
Pathways			mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs
Diseases
GWAS			Cholesterol, total ( 20686565) LDL cholesterol ( 20686565) Metabolite levels ( 22916037)
Protein-Protein Interactions		20 interactors: CCDC6 DHX38 HDAC3 IGBP1 JUN NFKB1 PPP2R1A PPP2R5D PPP4R1 PPP4R2 PPP4R4 REL RELA SMEK2 TIPRL TK1 TMSB4X TP53 TRAF6 TRIM28	6 interactors: CDC40 CSNK2A1 MFAP1 PPP4C TERF2IP U2AF1
Entrez ID		5531	9785
HPRD ID		03615	05720
Ensembl ID		ENSG00000149923	ENSG00000140829
Uniprot IDs		P60510	Q92620
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-12 Biosynthetic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor 4 Signaling Pathway Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Metabolic Process Response To Growth Factor Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-12 Biosynthetic Process NIK/NF-kappaB Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Transcription, DNA-templated Activation Of Innate Immune Response Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Interleukin-12 Production Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Innate Immune Response Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Death Regulation Of Catalytic Activity Response To Interleukin-1 Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin Signaling Pathway Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Innate Immune Response Positive Regulation Of Gene Expression Regulation Of Cell Death Regulation Of Cytokine Biosynthetic Process Innate Immune Response Immune System Process Membrane Protein Proteolysis Transcription From RNA Polymerase II Promoter Immune Response	Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Termination Of RNA Polymerase II Transcription Regulation Of DNA Repair MRNA Export From Nucleus Regulation Of DNA Recombination DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Recombination At Telomere RNA 3'-end Processing Nuclear Export MRNA Transport Regulation Of Response To DNA Damage Stimulus RNA Transport RNA Localization Regulation Of Chromosome Organization Transcription, DNA-templated Protection From Non-homologous End Joining At Telomere RNA Biosynthetic Process MRNA Splicing, Via Spliceosome Telomere Capping Protein Localization To Chromosome, Telomeric Region RNA Splicing, Via Transesterification Reactions Nucleocytoplasmic Transport Nuclear Transport Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance RNA Splicing RNA Metabolic Process MRNA Processing Regulation Of Telomere Maintenance Gene Expression RNA-dependent DNA Replication Negative Regulation Of DNA Recombination Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process MRNA Metabolic Process Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening RNA Processing Mitotic Spindle Checkpoint NIK/NF-kappaB Signaling Negative Regulation Of Chromosome Segregation Cytoplasmic Transport Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition
Tagcloud ?		6j acpp canonical carcinogenic cdk5 delineate e2f6 elf1 glands gprc5a hindered ingenuity ionizing ipa map2 mapk12 mapped microarray nab2 persistently perturbed plcg1 radiation runx1 scarcity sema4d stathmin1 surgically undertook
Tagcloud (Difference) ?		6j acpp canonical carcinogenic cdk5 delineate e2f6 elf1 glands gprc5a hindered ingenuity ionizing ipa map2 mapk12 mapped microarray nab2 persistently perturbed plcg1 radiation runx1 scarcity sema4d stathmin1 surgically undertook
Tagcloud (Intersection) ?