CD79A and BLNK

Number of citations of the paper that reports this interaction (PubMedID 11909947)
65

Data Source:
HPRD (in vitro, in vivo)

		CD79A	BLNK
Description		CD79a molecule	B cell linker
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GO Annotations	Cellular Component	Multivesicular Body Plasma Membrane External Side Of Plasma Membrane Membrane B Cell Receptor Complex Membrane Raft IgM B Cell Receptor Complex	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Lipid Binding Enzyme Binding Protein Kinase Binding Signaling Adaptor Activity SH2 Domain Binding Phospholipase Binding Molecular Condensate Scaffold Activity Protein Tyrosine Kinase Binding
	Biological Process	Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway B Cell Differentiation B Cell Proliferation B Cell Activation B Cell Receptor Signaling Pathway	Inflammatory Response Humoral Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Gene Expression B Cell Differentiation Intracellular Signal Transduction B Cell Activation B Cell Receptor Signaling Pathway
Pathways		CD22 mediated BCR regulation Potential therapeutics for SARS Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Regulation of signaling by CBL Potential therapeutics for SARS Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8	Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Brain morphology (MOSTest) ( 32665545)	Mean spheric corpuscular volume ( 32888494)
Interacting Genes		192 interacting genes: ADGRE2 ADIPOQ AGTRAP ALG10 ALG10B ALG3 APOD AQP1 AQP3 ARLN ATP6V0C BCL2L2 BET1 BLK BLNK BRICD5 BTN2A2 C14orf180 C1GALT1 C2CD2L CATSPERH CCDC167 CD19 CD5 CD79B CD81 CDIPT CLDN1 CLN6 CMTM5 CMTM7 CNIH1 CNIH3 COL4A5 CTSA CTXN3 CYB561 CYB561A3 CYB561D2 CYB5B DEFB127 DOLK EDDM3B EMC6 EMP1 EMP3 FA2H FAM241B FANCA FATE1 FAXDC2 FCAR FDFT1 FFAR3 FKBP8 FUNDC2 FXYD3 FYN GALNT15 GIMAP1 GJB1 GPR42 HACD4 HCLS1 HMOX1 HMOX2 HTATIP2 IER3 IGHM INSIG2 ITGAM JAGN1 JCHAIN KCNS2 LAMB1 LCK LEPROTL1 LHFPL5 LNPEP LPAR3 LTC4S LYN MALL MARCHF2 MFF MFSD12 MFSD6 MGLL MMD2 MOSPD3 MS4A13 MYADM MYADML2 NAT8 NEU1 NINJ2 NIPAL3 NKG7 ORMDL1 ORMDL2 OTOP2 PEX16 PGAP2 PIGR PKMYT1 PLP2 PLPP6 PLPPR2 PNLIPRP1 PRAF2 PTCH1 PTPN6 REEP6 RHO RTP2 SACM1L SEC22B SERP1 SFTPC SLC13A4 SLC13A5 SLC16A12 SLC16A13 SLC30A2 SLC30A3 SLC35B1 SLC35B4 SLC38A1 SLC39A2 SLC39A9 SLC41A1 SLC41A2 SLC46A3 SLC61A1 SLC66A2 SLC6A12 SLC7A1 SMCO4 SMIM3 STRIT1 STX12 STX3 STX8 SYK SYNJ2BP TECR THBD TM4SF19 TM4SF4 TMBIM6 TMEM107 TMEM11 TMEM128 TMEM140 TMEM147 TMEM14B TMEM176A TMEM187 TMEM19 TMEM218 TMEM222 TMEM229B TMEM239 TMEM243 TMEM254 TMEM42 TMEM86A TMEM86B TMEM97 TMPPE TNFRSF10C TRAM1L1 TRARG1 TSNARE1 TSPAN2 TSPO2 UBE2J1 UBIAD1 UNC93B1 UPK1B VAMP3 VAMP4 VAPA VAPB VTI1B WFDC2 WFS1 YIF1A YIPF4 YIPF6 ZDHHC15 ZDHHC22	25 interacting genes: AR BTK CBL CBLB CD72 CD79A CMTM3 CRKL EGFR ERBB2 ERBB3 GAB1 GRAP2 GRB2 ITK KIT LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1
Entrez ID		973	29760
HPRD ID		00203	05153
Ensembl ID		ENSG00000105369	ENSG00000095585
Uniprot IDs		P11912	Q2MD54 Q2MD59 Q8WV28
PDB IDs		1CV9 7WSO 7WSP 7XQ8 7XT6	6YLU
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding B Cell Receptor Signaling Pathway Plasma Membrane Transmembrane Transport Golgi Membrane SNAP Receptor Activity SNARE Complex Antigen Receptor-mediated Signaling Pathway Cellular Localization Membrane Docking Immune Response-regulating Cell Surface Receptor Signaling Pathway Membrane Fusion Vesicle Fusion Organelle Fusion Organelle Membrane Fusion Organelle Localization By Membrane Tethering Vesicle Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Localization Localization Within Membrane Protein Localization To Membrane T Cell Costimulation Chemical Homeostasis Membrane Organization Cholesterol Binding Immune Response-regulating Signaling Pathway Peptidyl-tyrosine Phosphorylation Monoatomic Cation Transmembrane Transporter Activity Intracellular Chemical Homeostasis Fc Receptor Signaling Pathway Metal Ion Transport Vesicle Fusion With Golgi Apparatus Vesicle-mediated Transport Endomembrane System Immune Response-activating Signaling Pathway Vesicle Docking Inorganic Cation Transmembrane Transport Membrane Lipid Metabolic Process Vacuolar Transmembrane Transport Phospholipase Binding Monoatomic Cation Transmembrane Transport Regulation Of Transport Regulation Of Immune System Process Establishment Of Localization In Cell Monoatomic Cation Transport Inorganic Ion Transmembrane Transport Monoatomic Ion Transport	Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Immune Response-regulating Signaling Pathway Immune Response-activating Signaling Pathway Activation Of Immune Response Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Intracellular Signal Transduction T Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune System Process Leukocyte Activation Lymphocyte Activation B Cell Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Regulation Of MAPK Cascade Intracellular Signaling Cassette Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cell-cell Junction Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling T Cell Activation Immune System Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Protein Tyrosine Kinase Activity Positive Regulation Of Multicellular Organismal Process Leukocyte Proliferation ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Regulation Of Lymphocyte Activation Receptor Tyrosine Kinase Binding Cell Population Proliferation Plasma Membrane Negative Regulation Of Immune System Process
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