ZFYVE21 and REEP6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		ZFYVE21	REEP6
Description		zinc finger FYVE-type containing 21	receptor accessory protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Focal Adhesion Cytoplasmic Vesicle Anchoring Junction	Photoreceptor Inner Segment Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding
	Biological Process		Endoplasmic Reticulum Organization Regulation Of Intracellular Transport Detection Of Light Stimulus Involved In Visual Perception
Pathways
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 26426971) Hemoglobin ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		28 interacting genes: AGTRAP ARL6IP1 CAPN2 CMTM4 FBXO7 KRT31 KRT38 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP5-9 MID2 MTUS2 NOTCH2NLA PDE4DIP PTK2 PYCARD RABAC1 REEP6 RTN4 RUBCN SIAH1 SMIM5 TRAF1 TRIM27 TUBB YIF1A	46 interacting genes: AQP6 ARL6IP1 ATP5PF BIK CD79A CDC37 CERT1 COQ8A CYB561 CYB5R3 EBAG9 FHIP1B GJA8 GORASP2 GPR152 HMBOX1 HSD17B13 KRTAP3-1 LEPROTL1 LITAF LMNA LNX1 MIEF2 NDRG4 NTAQ1 PICK1 PTPN9 RPS20 SDCBP SLC30A8 SNX1 SNX11 SNX15 SNX8 SPG21 STING1 SYT16 TIMMDC1 TLCD4 TMED8 TMEM143 TMPPE TNS2 TXN2 WIPI2 ZFYVE21
Entrez ID		79038	92840
HPRD ID		15733	16629
Ensembl ID		ENSG00000100711	ENSG00000115255
Uniprot IDs		Q9BQ24	A0A1L5BXV2 Q96HR9
PDB IDs		2RRF
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Endoplasmic Reticulum Tubular Network Formation Identical Protein Binding Phosphatidylinositol 3-kinase Inhibitor Activity Endoplasmic Reticulum Tubular Network Membrane Organization Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Endoplasmic Reticulum Organization Structural Molecule Activity Intermediate Filament Organization Vascular Endothelial Cell Response To Fluid Shear Stress Negative Regulation Of Viral Transcription Regulation Of Autophagy Endoplasmic Reticulum Membrane Organization Suppression Of Viral Release By Host Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Viral Transcription Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Mononuclear Cell Migration Endoplasmic Reticulum Tubular Network Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Macrophage Migration Regulation Of Apoptotic Process Cellular Response To Fluid Shear Stress Regulation Of Cytoskeleton Organization Cytosol Ubiquitin Protein Ligase Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Myosin I Binding Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Regulation Of Mononuclear Cell Migration Cytoskeleton Positive Regulation Of Leukocyte Migration Regulation Of Macrophage Cytokine Production Regulation Of Programmed Cell Death Microtubule Response To Fluid Shear Stress	Lipid Binding Establishment Of Protein Localization Identical Protein Binding Membrane
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