SOCS5 and IL4R

Number of citations of the paper that reports this interaction (PMID 12242343)
35

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro)

		SOCS5	IL4R
Gene Name		suppressor of cytokine signaling 5	interleukin 4 receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Extracellular Space Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Protein Kinase Inhibitor Activity Epidermal Growth Factor Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding	Interleukin-4 Receptor Activity Receptor Signaling Protein Activity Protein Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity JAK-STAT Cascade Negative Regulation Of Signal Transduction Cell Growth Protein Ubiquitination Cytokine-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Growth Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of JAK-STAT Cascade	Production Of Molecular Mediator Involved In Inflammatory Response Immune Response Signal Transduction Ovulation Intracellular Signal Transduction Interleukin-4-mediated Signaling Pathway Regulation Of Cell Proliferation Defense Response To Protozoan Positive Regulation Of Macrophage Activation Response To Estrogen Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Chemokine Secretion
Pathways
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 21685187) Height ( 20881960)	IgE levels ( 22075330)
Protein-Protein Interactions		7 interactors: APP CASP3 EGFR IL4R KIT TMBIM1 UBC	22 interactors: ARIH2 CD40 DOK2 FES GNB2L1 HGS IL13 IL13RA1 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 SHC1 SOCS5 STAT6
Entrez ID		9655	3566
HPRD ID		06159	00990
Ensembl ID		ENSG00000171150	ENSG00000077238
Uniprot IDs		O75159	B2RBY1 B4E076 P24394
PDB IDs			1IAR 1IRS 1ITE 3BPL 3BPN 3BPO
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Response To Light Stimulus Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Protein Phosphorylation Immune System Process Response To Abiotic Stimulus Response To Radiation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Defense Response ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Response To Fibroblast Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Cell Death Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAP Kinase Activity Response To Cytokine Fc-epsilon Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Innate Immune Response Learning Or Memory Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Immune Response Positive Regulation Of Cell Cycle Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Stress Cognition	Positive Regulation Of Cell Activation Regulation Of Cell Activation Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Proliferation Cell Surface Receptor Signaling Pathway Immune System Process Positive Regulation Of Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of B Cell Activation Immune Response Defense Response Cellular Response To Organic Substance Response To Cytokine JAK-STAT Cascade Response To Organic Substance Signal Transduction Regulation Of Signaling Regulation Of B Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Cytokine Stimulus Innate Immune Response Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Cell Proliferation Regulation Of Signal Transduction Signaling Cell Communication Positive Regulation Of Immunoglobulin Production Epidermal Growth Factor Receptor Signaling Pathway Cytokine-mediated Signaling Pathway ERBB Signaling Pathway Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Signal Transduction Regulation Of Adaptive Immune Response Regulation Of JAK-STAT Cascade Cellular Response To Peptide Regulation Of Phosphorylation Response To Growth Hormone Positive Regulation Of B Cell Proliferation Regulation Of Cellular Localization Regulation Of Kinase Activity Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Cellular Response To Stimulus
Tagcloud ?		actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 targetable uniform v600e	4ps ba compatible coupling depend equimolar exclusive f3 heterodimerization i4r il2 il2r il7 il9 immunoblotting jak1 jak3 manifest mutational phosphotyrosine preferential premyeloid share stably subordinate tf tyk2 vigorous
Tagcloud (Difference) ?		actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 targetable uniform v600e	4ps ba compatible coupling depend equimolar exclusive f3 heterodimerization i4r il2 il2r il7 il9 immunoblotting jak1 jak3 manifest mutational phosphotyrosine preferential premyeloid share stably subordinate tf tyk2 vigorous
Tagcloud (Intersection) ?