SOCS5

Description		suppressor of cytokine signaling 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interleukin-6 Production Intracellular Signal Transduction Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Inflammatory Response Cellular Response To Low-density Lipoprotein Particle Stimulus Negative Regulation Of Monocyte Chemotactic Protein-1 Production Vascular Endothelial Cell Response To Fluid Shear Stress
Pathways		Interleukin-4 and Interleukin-13 signaling Neddylation
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Cerebrospinal P-tau181p levels ( 28247064) Chronotype ( 30696823) Current cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Height ( 20881960 28552196) Offspring birth weight ( 31043758) Pulse pressure (alcohol consumption interaction) ( 24376456) Waist circumference adjusted for body mass index ( 34021172)
Novel Interacting Genes		1 novel interacting genes: PLCB2
Interacting Genes		11 interacting genes: APP CASP3 EGFR ERBB2 ERBB3 ERBB4 IL4R KIT MET TMBIM1 UBC
Entrez ID		9655
HPRD ID		06159
Ensembl ID		ENSG00000171150
Uniprot IDs		O75159
PDB IDs
Enriched GO Terms of Interacting Partners?		Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Basal Plasma Membrane ERBB2 Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Programmed Cell Death Neuron Differentiation Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAPK Cascade ERBB3:ERBB2 Complex Protein Kinase Activity Cell Surface Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of Phosphate Metabolic Process Kinase Activity Signal Transduction Regulation Of MAPK Cascade Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Response To Epidermal Growth Factor Positive Regulation Of Protein Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Glial Cell Development ERBB2-EGFR Signaling Pathway Animal Organ Development Cellular Developmental Process Regulation Of Apoptotic Process Positive Regulation Of Protein Phosphorylation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Regulation Of Multicellular Organismal Process Basolateral Plasma Membrane Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Neuron Apoptotic Process Regulation Of Phosphorus Metabolic Process Heart Development Positive Regulation Of Macromolecule Metabolic Process Learning Or Memory Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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