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SOCS5 and TMBIM1
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
SOCS5
TMBIM1
Gene Name
suppressor of cytokine signaling 5
transmembrane BAX inhibitor motif containing 1
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Lysosomal Membrane
Golgi Apparatus
Endosome Membrane
Integral Component Of Membrane
Extracellular Vesicular Exosome
Molecular Function
Protein Kinase Inhibitor Activity
Epidermal Growth Factor Receptor Binding
Protein Binding
Receptor Tyrosine Kinase Binding
Death Receptor Binding
Biological Process
Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity
JAK-STAT Cascade
Negative Regulation Of Signal Transduction
Cell Growth
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Growth
Positive Regulation Of T-helper 1 Cell Differentiation
Negative Regulation Of T-helper 2 Cell Differentiation
Negative Regulation Of JAK-STAT Cascade
Negative Regulation Of Metalloenzyme Activity
Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Fas Signaling Pathway
Positive Regulation Of Blood Vessel Remodeling
Pathways
Drugs
Diseases
GWAS
Chronic obstructive pulmonary disease (
21685187
)
Height (
20881960
)
Inflammatory bowel disease (
23128233
)
Protein-Protein Interactions
7 interactors:
APP
CASP3
EGFR
IL4R
KIT
TMBIM1
UBC
2 interactors:
RCHY1
SOCS5
Entrez ID
9655
64114
HPRD ID
06159
17884
Ensembl ID
ENSG00000171150
ENSG00000135926
Uniprot IDs
O75159
B3KSM0
Q969X1
PDB IDs
Enriched GO Terms of Interacting Partners
?
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of ERBB Signaling Pathway
Response To Light Stimulus
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Cell Death
Regulation Of Protein Phosphorylation
Immune System Process
Response To Abiotic Stimulus
Response To Radiation
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Protein Metabolic Process
Immune Response
Regulation Of Immune System Process
Regulation Of Phosphorylation
Epidermal Growth Factor Receptor Signaling Pathway
Defense Response
ERBB Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Cellular Response To Fibroblast Growth Factor Stimulus
Regulation Of Phosphorus Metabolic Process
Response To Fibroblast Growth Factor
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Catalytic Activity
Regulation Of Cell Death
Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of MAP Kinase Activity
Response To Cytokine
Fc-epsilon Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Negative Regulation Of Catalytic Activity
Innate Immune Response
Learning Or Memory
Fc Receptor Signaling Pathway
Activation Of Protein Kinase Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Signal Transduction By Phosphorylation
Intracellular Signal Transduction
Cellular Response To Organic Substance
Regulation Of Immune Response
Positive Regulation Of Cell Cycle
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Response To Stress
Cognition
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Proteolysis
Regulation Of Protein Catabolic Process
Negative Regulation Of T-helper 2 Cell Differentiation
Positive Regulation Of T-helper 1 Cell Differentiation
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Regulation Of Proteolysis
Regulation Of T-helper 1 Cell Differentiation
Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity
Negative Regulation Of T-helper Cell Differentiation
Positive Regulation Of T-helper 1 Type Immune Response
Negative Regulation Of Alpha-beta T Cell Differentiation
Negative Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of Type 2 Immune Response
Negative Regulation Of JAK-STAT Cascade
Negative Regulation Of Alpha-beta T Cell Activation
Negative Regulation Of Receptor Activity
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of T-helper Cell Differentiation
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation
Regulation Of T-helper Cell Differentiation
Negative Regulation Of T Cell Differentiation
Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Protein Autoubiquitination
Positive Regulation Of Alpha-beta T Cell Differentiation
Regulation Of Type 2 Immune Response
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
Negative Regulation Of ERBB Signaling Pathway
Negative Regulation Of Lymphocyte Differentiation
JAK-STAT Cascade
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Tyrosine Kinase Activity
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of ERBB Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of T Cell Differentiation
Regulation Of JAK-STAT Cascade
Positive Regulation Of Lymphocyte Differentiation
Negative Regulation Of T Cell Activation
Tagcloud
?
actionable
adenocarcinomas
akt1
alk
braf
capture
ccdc6
cd74
clip4
deemed
driver
fusions
g719a
genomic
introns
kif5b
map2k1
nccn
ngs
nras
pack
pik3ca
profiling
rearranged
ret
ros1
targetable
uniform
v600e
Tagcloud (Difference)
?
actionable
adenocarcinomas
akt1
alk
braf
capture
ccdc6
cd74
clip4
deemed
driver
fusions
g719a
genomic
introns
kif5b
map2k1
nccn
ngs
nras
pack
pik3ca
profiling
rearranged
ret
ros1
targetable
uniform
v600e
Tagcloud (Intersection)
?