SOCS5 and TMBIM1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SOCS5	TMBIM1
Gene Name		suppressor of cytokine signaling 5	transmembrane BAX inhibitor motif containing 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Lysosomal Membrane Golgi Apparatus Endosome Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Inhibitor Activity Epidermal Growth Factor Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding	Death Receptor Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity JAK-STAT Cascade Negative Regulation Of Signal Transduction Cell Growth Protein Ubiquitination Cytokine-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Growth Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of JAK-STAT Cascade	Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Fas Signaling Pathway Positive Regulation Of Blood Vessel Remodeling
Pathways
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 21685187) Height ( 20881960)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		7 interactors: APP CASP3 EGFR IL4R KIT TMBIM1 UBC	2 interactors: RCHY1 SOCS5
Entrez ID		9655	64114
HPRD ID		06159	17884
Ensembl ID		ENSG00000171150	ENSG00000135926
Uniprot IDs		O75159	B3KSM0 Q969X1
PDB IDs
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Response To Light Stimulus Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Protein Phosphorylation Immune System Process Response To Abiotic Stimulus Response To Radiation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Defense Response ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Response To Fibroblast Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Cell Death Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAP Kinase Activity Response To Cytokine Fc-epsilon Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Innate Immune Response Learning Or Memory Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Immune Response Positive Regulation Of Cell Cycle Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Stress Cognition	Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of T-helper 1 Cell Differentiation Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of T-helper Cell Differentiation Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Type 2 Immune Response Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Alpha-beta T Cell Activation Negative Regulation Of Receptor Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of T-helper Cell Differentiation Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Protein Metabolic Process Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of T-helper Cell Differentiation Negative Regulation Of T Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Protein Autoubiquitination Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of Type 2 Immune Response Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Lymphocyte Differentiation JAK-STAT Cascade Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Tyrosine Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of T Cell Differentiation Regulation Of JAK-STAT Cascade Positive Regulation Of Lymphocyte Differentiation Negative Regulation Of T Cell Activation
Tagcloud ?		actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 targetable uniform v600e
Tagcloud (Difference) ?		actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 targetable uniform v600e
Tagcloud (Intersection) ?