SNCAIP and SEPTIN4

Number of citations of the paper that reports this interaction (PubMedID 12695511)
0

Data Source:
HPRD (in vivo)

		SNCAIP	SEPTIN4
Description		synuclein alpha interacting protein	septin 4
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Synaptic Vesicle Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Neuronal Cell Body	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cilium Septin Ring Synaptic Vesicle Microtubule Cytoskeleton Transport Vesicle Axon Dendrite Septin Complex Cytoplasmic Vesicle Motile Cilium Cell Division Site Cell Projection Perikaryon Synapse Sperm Annulus Dopaminergic Synapse Presynapse
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding	Nucleotide Binding Magnesium Ion Binding GTPase Activity Structural Molecule Activity Protein Binding GTP Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Cell Death Dopamine Metabolic Process Regulation Of Neurotransmitter Secretion Regulation Of Inclusion Body Assembly	Neuron Migration Apoptotic Process Spermatogenesis Intracellular Protein Localization Regulation Of Exocytosis Cell Differentiation Flagellated Sperm Motility Positive Regulation Of Protein Ubiquitination Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Spermatid Differentiation Cell Division Hematopoietic Stem Cell Homeostasis Cytoskeleton-dependent Cytokinesis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Amyloid fiber formation
Drugs
Diseases
GWAS		Chronic kidney disease (end stage renal disease vs. normal eGFR) in type 1 diabetes ( 31537649) Delirium ( 29631748) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Mood disorder and prion disease ( 25897833) Response to paclitaxel in ovarian cancer (Caspase 3/7 EC50) ( 27047539)
Interacting Genes		19 interacting genes: AGXT C11orf58 GET4 GSK3B NUB1 NUDT21 PIN1 PINK1 PPHLN1 PRKN PTN RNF19A SEPTIN4 SH2D3C SIAH1 SIAH2 SNCA TLE5 UBB	10 interacting genes: AREL1 BCL2 PRKN SEPTIN5 SEPTIN8 SNCA SNCAIP SNCB TSC2 XIAP
Entrez ID		9627	5414
HPRD ID		04804	04738
Ensembl ID		ENSG00000064692	ENSG00000108387
Uniprot IDs		B7Z616 B7Z995 Q6L981 Q6L983 Q9Y6H5	J3KSZ7 O43236
PDB IDs		2KES	6WB3
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Lewy Body Amyloid Fibril Formation Ubiquitin Conjugating Enzyme Binding Regulation Of Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Apoptotic Signaling Pathway Regulation Of Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Macromolecule Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Dopamine Transport Proteolysis Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Dopamine Secretion Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Stability Protein Ubiquitination Mitochondrial Outer Membrane Axon Regulation Of Protein Modification Process Mitochondrion To Lysosome Vesicle-mediated Transport Cellular Response To Hydrogen Sulfide Monoamine Transport Protein Modification By Small Protein Conjugation Regulation Of Canonical Wnt Signaling Pathway Regulation Of Neuron Apoptotic Process Response To Hydrogen Sulfide Regulation Of Apoptotic Process Proteasomal Protein Catabolic Process Regulation Of Programmed Cell Death Regulation Of Catecholamine Secretion Catabolic Process Negative Regulation Of Mitochondrial Fission Regulation Of Synaptic Vesicle Transport Regulation Of Protein Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Tau Protein Binding Positive Regulation Of Protein Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Post-translational Protein Modification Regulation Of Wnt Signaling Pathway Protein Modification Process Cytosol Negative Regulation Of Wnt Signaling Pathway	Phenol-containing Compound Metabolic Process Dopamine Metabolic Process Catecholamine Metabolic Process Biogenic Amine Metabolic Process Amine Metabolic Process Regulation Of Neurotransmitter Secretion Cell Death Positive Regulation Of Protein Linear Polyubiquitination Neuron Apoptotic Process Synaptic Vesicle Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Process Molecular Adaptor Activity Apoptotic Process Negative Regulation Of Programmed Cell Death Programmed Cell Death Dopamine Uptake Involved In Synaptic Transmission Regulation Of Transport Regulation Of Neuron Apoptotic Process Cuprous Ion Binding Protein Polyubiquitination Catecholamine Uptake Dopamine Uptake Septin Ring Septin Complex Negative Regulation Of Autophagy Cell Division Site Synaptic Transmission, Dopaminergic Regulation Of SNARE Complex Assembly Neuronal Cell Body Regulation Of Protein Stability Regulation Of Autophagy Positive Regulation Of Protein Polyubiquitination Regulation Of Apoptotic Process Dopamine Transport Neurotransmitter Reuptake Synaptic Vesicle Membrane Regulation Of Neurotransmitter Uptake Regulation Of Dopamine Metabolic Process Inclusion Body Regulation Of Programmed Cell Death Phospholipase Binding Adult Behavior Regulation Of Dopamine Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Synapse Regulation Of Protein Polyubiquitination Modulation Of Chemical Synaptic Transmission Monoamine Transport Amyloid Fibril Formation
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