SNCAIP and NUB1

Number of citations of the paper that reports this interaction (PubMedID 17549501)
0

Data Source:
BioGRID (two hybrid)

		SNCAIP	NUB1
Description		synuclein alpha interacting protein	negative regulator of ubiquitin like proteins 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Synaptic Vesicle Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Neuronal Cell Body	Nucleus Nucleoplasm Nucleolus Cytosol Lewy Body
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding	Protein Binding
	Biological Process	Cell Death Dopamine Metabolic Process Regulation Of Neurotransmitter Secretion Regulation Of Inclusion Body Assembly	Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Type II Interferon Response To Tumor Necrosis Factor Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Amyloid fiber formation
Drugs
Diseases
GWAS		Chronic kidney disease (end stage renal disease vs. normal eGFR) in type 1 diabetes ( 31537649) Delirium ( 29631748) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Mood disorder and prion disease ( 25897833) Response to paclitaxel in ovarian cancer (Caspase 3/7 EC50) ( 27047539)	Body fat mass ( 28552196) Carotid plaque burden ( 28282560) Eyebrow thickness ( 26926045)
Interacting Genes		19 interacting genes: AGXT C11orf58 GET4 GSK3B NUB1 NUDT21 PIN1 PINK1 PPHLN1 PRKN PTN RNF19A SEPTIN4 SH2D3C SIAH1 SIAH2 SNCA TLE5 UBB	12 interacting genes: AIPL1 COPB1 FANCA NEDD8 PSMD2 PSMD4 SF3B4 SNCAIP UBD UBE2K UFD1 VCP
Entrez ID		9627	51667
HPRD ID		04804	07450
Ensembl ID		ENSG00000064692	ENSG00000013374
Uniprot IDs		B7Z616 B7Z995 Q6L981 Q6L983 Q9Y6H5	H3BM14 H3BM74 Q9Y5A7
PDB IDs		2KES	1WJU 8USB 8USC 8USD 9E8G 9E8H 9E8I 9E8J 9E8L 9E8N
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Lewy Body Amyloid Fibril Formation Ubiquitin Conjugating Enzyme Binding Regulation Of Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Apoptotic Signaling Pathway Regulation Of Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Macromolecule Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Dopamine Transport Proteolysis Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Dopamine Secretion Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Stability Protein Ubiquitination Mitochondrial Outer Membrane Axon Regulation Of Protein Modification Process Mitochondrion To Lysosome Vesicle-mediated Transport Cellular Response To Hydrogen Sulfide Monoamine Transport Protein Modification By Small Protein Conjugation Regulation Of Canonical Wnt Signaling Pathway Regulation Of Neuron Apoptotic Process Response To Hydrogen Sulfide Regulation Of Apoptotic Process Proteasomal Protein Catabolic Process Regulation Of Programmed Cell Death Regulation Of Catecholamine Secretion Catabolic Process Negative Regulation Of Mitochondrial Fission Regulation Of Synaptic Vesicle Transport Regulation Of Protein Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Tau Protein Binding Positive Regulation Of Protein Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Post-translational Protein Modification Regulation Of Wnt Signaling Pathway Protein Modification Process Cytosol Negative Regulation Of Wnt Signaling Pathway	Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Polyubiquitin Modification-dependent Protein Binding Proteolysis Aggresome Assembly Proteasome Complex Nucleoplasm VCP-NPL4-UFD1 AAA ATPase Complex Inclusion Body Assembly K48-linked Polyubiquitin Modification-dependent Protein Binding Cytosol Cellular Response To Misfolded Protein Proteasome Regulatory Particle, Base Subcomplex Response To Misfolded Protein Ubiquitin Protein Ligase Binding Proteasome Accessory Complex Retrograde Protein Transport, ER To Cytosol Catabolic Process Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Topologically Incorrect Protein Protein Metabolic Process Protein Exit From Endoplasmic Reticulum Proteasomal Protein Catabolic Process Interstrand Cross-link Repair Protein Ubiquitination Protein Catabolic Process Flavin Adenine Dinucleotide Catabolic Process Farnesylated Protein Binding Protein Modification By Small Protein Conjugation Proteasome Storage Granule UFD1-NPL4 Complex VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Nucleus Post-translational Protein Modification Regulation Of Protein Catabolic Process Regulation Of Proteolysis ERAD Pathway Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Protein Farnesylation Cytoplasm Protein Quality Control BAT3 Complex Binding Secretory Granule Lumen Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
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