SNCAIP and AGXT

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SNCAIP	AGXT
Gene Name		synuclein, alpha interacting protein	alanine-glyoxylate aminotransferase
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Synaptic Vesicle Presynaptic Membrane Neuronal Cell Body	Mitochondrial Matrix Peroxisome Peroxisomal Matrix
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding	Serine-pyruvate Transaminase Activity Receptor Binding Protein Binding Alanine-glyoxylate Transaminase Activity Transaminase Activity Amino Acid Binding Pyridoxal Phosphate Binding Protein Homodimerization Activity
	Biological Process	Dopamine Metabolic Process Regulation Of Neurotransmitter Secretion Regulation Of Inclusion Body Assembly	Glyoxylate Catabolic Process Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-cysteine Catabolic Process Cellular Nitrogen Compound Metabolic Process L-alanine Catabolic Process Pyruvate Biosynthetic Process Small Molecule Metabolic Process Glyoxylate Metabolic Process Oxalic Acid Secretion Response To Glucocorticoid Response To CAMP
Pathways			Glyoxylate metabolism Metabolism of amino acids and derivatives
Drugs			Pyridoxal Phosphate L-Serine Glycine L-Alanine (Aminooxy)Acetic Acid N\'-Pyridoxyl-Lysine-5\'-Monophosphate 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID
Diseases
GWAS
Protein-Protein Interactions		19 interactors: AES AGXT C11orf58 GET4 GSK3B NUB1 NUDT21 PARK2 PINK1 PPHLN1 PPP1CA PTN RNF19A SEPT4 SH2D3C SIAH1 SIAH2 SNCA UBB	3 interactors: ACAT1 PEX5 SNCAIP
Entrez ID		9627	189
HPRD ID		04804	05048
Ensembl ID		ENSG00000064692	ENSG00000172482
Uniprot IDs		Q9NVG1 Q9Y6H5	P21549
PDB IDs		2KES	1H0C 1J04 3R9A 4I8A
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Proteolysis Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Protein Ubiquitination Regulation Of Proteolysis Regulation Of Dopamine Secretion Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signal Transduction Ubiquitin-dependent Protein Catabolic Process Dopamine Uptake Involved In Synaptic Transmission Modification-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Synaptic Vesicle Transport Regulation Of Signaling Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Carbohydrate Metabolic Process Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Mitochondrion Organization Positive Regulation Of Cellular Protein Metabolic Process Generation Of Precursor Metabolites And Energy Glycogen Metabolic Process Negative Regulation Of Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catalytic Activity Positive Regulation Of Mitochondrial Fission Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process	Cholesterol Storage Lipid Modification Carboxylic Acid Catabolic Process Metanephric Proximal Convoluted Tubule Development Negative Regulation Of Protein Homotetramerization Protein Import Into Peroxisome Matrix, Translocation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Macrophage Derived Foam Cell Differentiation Metanephric Proximal Tubule Development Cholesterol Esterification Protein Import Into Peroxisome Matrix, Docking Ketone Body Catabolic Process Proximal Tubule Development Negative Regulation Of Protein Homooligomerization Protein Import Into Peroxisome Membrane Protein To Membrane Docking Protein Oligomerization Regulation Of Amyloid Precursor Protein Biosynthetic Process Very-low-density Lipoprotein Particle Assembly Peroxisomal Membrane Transport Negative Regulation Of Protein Oligomerization Ketone Body Biosynthetic Process Cellular Ketone Body Metabolic Process Protein Import Into Peroxisome Matrix Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Glycoprotein Metabolic Process Metanephric Nephron Tubule Development Protein-lipid Complex Assembly Regulation Of Inclusion Body Assembly Branched-chain Amino Acid Catabolic Process Brain Development Establishment Of Protein Localization To Peroxisome Protein Targeting To Peroxisome Head Development Very Long-chain Fatty Acid Metabolic Process Cerebral Cortex Neuron Differentiation Dopamine Metabolic Process Cholesterol Efflux Regulation Of Protein Oligomerization Regulation Of Glycoprotein Biosynthetic Process Metanephric Epithelium Development Adipose Tissue Development Cellular Lipid Metabolic Process Central Nervous System Development Lipid Storage Endoplasmic Reticulum Organization Catecholamine Metabolic Process Fatty Acid Beta-oxidation Peroxisome Organization Carboxylic Acid Metabolic Process
Tagcloud ?		adar colorectal contain dcaf12l2 exomes glt1d1 hot instability itga7 map1b microsatellite mrgprx4 oncogenes personalized profiling psrc1 ranbp2 respective rps6kl1 sequenced spot spots tceal6 tubb6 validated validation vegfb wbp5 zbtb2	aim2 alox12 built cpg discriminate discriminated e85 epigenome false il10 jak3 lcn2 leukocyte manifested methqtl obtainable p1075 p180 p220 p348 p624 p817 p86 pac penalized resectable smoker statistic zap70
Tagcloud (Difference) ?		adar colorectal contain dcaf12l2 exomes glt1d1 hot instability itga7 map1b microsatellite mrgprx4 oncogenes personalized profiling psrc1 ranbp2 respective rps6kl1 sequenced spot spots tceal6 tubb6 validated validation vegfb wbp5 zbtb2	aim2 alox12 built cpg discriminate discriminated e85 epigenome false il10 jak3 lcn2 leukocyte manifested methqtl obtainable p1075 p180 p220 p348 p624 p817 p86 pac penalized resectable smoker statistic zap70
Tagcloud (Intersection) ?