AATK and DUSP6

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		AATK	DUSP6
Description		apoptosis associated tyrosine kinase	dual specificity phosphatase 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endomembrane System Membrane Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity
	Biological Process	Brain Development Neuron Apoptotic Process	MAPK Cascade Signal Transduction Response To Xenobiotic Stimulus Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Response To Nitrosative Stress Regulation Of Heart Growth ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor
Pathways			RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) Beef consumption ( 32066663) Lymphocyte percentage of white cells ( 32888494) Neuroticism ( 29255261) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Age at first sexual intercourse ( 34211149) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 29325848 30478444) Night sleep phenotypes ( 27126917)
Interacting Genes		41 interacting genes: BDKRB2 CDC14A CDC25B CDK5 DUSP1 DUSP14 DUSP29 DUSP5 DUSP6 DUSP9 ERBB2 EYA2 EYA4 ILKAP MTMR10 MTMR6 MTMR8 MTMR9 PPM1A PPM1B PPM1F PPM1K PPM1M PPP1CA PPP3CA PPP3CB PTEN PTPDC1 PTPN11 PTPN12 PTPN18 PTPN20 PTPN6 PTPN7 PTPRR SBF1 STK39 STYX TAB1 TEPSIN TPTE2	12 interacting genes: AATK ERBB4 LMTK2 LTK MAPK1 MAPK3 MDFI ROR2 SRPK1 TEX11 TXK ZNF212
Entrez ID		9625	1848
HPRD ID		05591	04124
Ensembl ID		ENSG00000181409	ENSG00000139318
Uniprot IDs		H7C175 Q6ZMQ8	Q16828 Q53GP9
PDB IDs			1HZM 1MKP
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Dephosphorylation Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Protein Serine/threonine Phosphatase Activity Hydrolase Activity Phosphate-containing Compound Metabolic Process Protein Tyrosine/serine/threonine Phosphatase Activity Protein Modification Process Peptidyl-tyrosine Dephosphorylation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Cytoplasm MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Negative Regulation Of Signaling Regulation Of Signal Transduction Cytosol Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Negative Regulation Of Cell Communication Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Phosphatase Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of MAPK Cascade Phosphatidylinositol Dephosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Peptidyl-threonine Dephosphorylation Negative Regulation Of Intracellular Signal Transduction Phospholipid Dephosphorylation Macromolecule Metabolic Process Intracellular Signaling Cassette Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Intracellular Signal Transduction ERK1 And ERK2 Cascade Manganese Ion Binding Cerebellar Cortex Formation Peptidyl-serine Dephosphorylation Phosphatidylinositol Metabolic Process Phosphatidylinositol-3,5-bisphosphate Phosphatase Activity MAPK Cascade N-terminal Protein Myristoylation ErbB-3 Class Receptor Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Negative Regulation Of Transport Nucleoplasm	Protein Kinase Activity Kinase Activity Protein Tyrosine Kinase Activity Protein Phosphorylation Phosphorylation Protein Autophosphorylation ATP Binding ERBB2 Signaling Pathway Protein Serine Kinase Activity Interleukin-34-mediated Signaling Pathway Protein Serine/threonine Kinase Activity Nucleotide Binding Transferase Activity Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Golgi Inheritance Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Neuroinflammatory Response Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Peptidyl-tyrosine Autophosphorylation Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Bergmann Glial Cell Differentiation Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway ERBB Signaling Pathway Insulin Receptor Signaling Pathway Cellular Developmental Process MAP Kinase Activity GABA Receptor Binding Regulation Of Golgi Organization Pseudopodium Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Positive Regulation Of Macrophage Chemotaxis Gland Development Glial Cell Differentiation Positive Regulation Of Neuroinflammatory Response Animal Organ Formation Face Development Peptidyl-threonine Phosphorylation Stress-activated MAPK Cascade Cell Development
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