DUSP6 and LMTK2

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		DUSP6	LMTK2
Description		dual specificity phosphatase 6	lemur tyrosine kinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Cytoplasm Early Endosome Golgi Apparatus Endomembrane System Membrane Growth Cone Neuronal Cell Body Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Phosphatase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Myosin VI Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Signal Transduction Response To Xenobiotic Stimulus Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Response To Nitrosative Stress Regulation Of Heart Growth ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor	Receptor Recycling Protein Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Endocytic Recycling Transferrin Transport Early Endosome To Late Endosome Transport Protein Autophosphorylation
Pathways		RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 29325848 30478444) Night sleep phenotypes ( 27126917)	Gamma glutamyl transferase levels ( 29403010 33339817) Hemoglobin levels ( 32327693) Prostate cancer ( 18264097) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)
Interacting Genes		12 interacting genes: AATK ERBB4 LMTK2 LTK MAPK1 MAPK3 MDFI ROR2 SRPK1 TEX11 TXK ZNF212	24 interacting genes: CDC14A CDC25C CDK5 CDK5R1 DUSP14 DUSP19 DUSP29 DUSP6 ILKAP MTMR6 PPM1A PPM1F PPM1K PPP1CA PPP1CB PPP1CC PPP1R2 PPP3CB PTPDC1 PTPN12 PTPN6 PTPRR STYX TPTE2
Entrez ID		1848	22853
HPRD ID		04124	13994
Ensembl ID		ENSG00000139318	ENSG00000164715
Uniprot IDs		Q16828 Q53GP9	Q8IWU2
PDB IDs		1HZM 1MKP
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Kinase Activity Protein Tyrosine Kinase Activity Protein Phosphorylation Phosphorylation Protein Autophosphorylation ATP Binding ERBB2 Signaling Pathway Protein Serine Kinase Activity Interleukin-34-mediated Signaling Pathway Protein Serine/threonine Kinase Activity Nucleotide Binding Transferase Activity Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Golgi Inheritance Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Neuroinflammatory Response Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Peptidyl-tyrosine Autophosphorylation Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Bergmann Glial Cell Differentiation Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway ERBB Signaling Pathway Insulin Receptor Signaling Pathway Cellular Developmental Process MAP Kinase Activity GABA Receptor Binding Regulation Of Golgi Organization Pseudopodium Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Positive Regulation Of Macrophage Chemotaxis Gland Development Glial Cell Differentiation Positive Regulation Of Neuroinflammatory Response Animal Organ Formation Face Development Peptidyl-threonine Phosphorylation Stress-activated MAPK Cascade Cell Development	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Dephosphorylation Hydrolase Activity Cation Binding Phosphate-containing Compound Metabolic Process Protein Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Phosphatase Activity PTW/PP1 Phosphatase Complex Protein Modification Process Glycogen Metabolic Process Cytoplasm Negative Regulation Of MAPK Cascade Peptidyl-tyrosine Dephosphorylation Energy Reserve Metabolic Process Polysaccharide Metabolic Process Entrainment Of Circadian Clock By Photoperiod Protein Kinase 5 Complex Photoperiodism Entrainment Of Circadian Clock Cytosol MAPK Cascade Rhythmic Process Cell Division Protein Kinase Binding Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Circadian Regulation Of Gene Expression Energy Derivation By Oxidation Of Organic Compounds Non-membrane Spanning Protein Tyrosine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Nucleoplasm Protein Metabolic Process Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Phosphatase Activity Layer Formation In Cerebral Cortex Negative Regulation Of Intracellular Signal Transduction Regulation Of Circadian Rhythm Protein Phosphatase 1 Binding Positive Regulation Of Protein Targeting To Membrane Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Localization Negative Regulation Of Signaling Regulation Of Establishment Of Protein Localization
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