AATK and PPP3CB

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		AATK	PPP3CB
Description		apoptosis associated tyrosine kinase	protein phosphatase 3 catalytic subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endomembrane System Membrane Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Calcineurin Complex Protein Serine/threonine Phosphatase Complex Z Disc T-tubule Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Hydrolase Activity Enzyme Binding Protein Phosphatase 2B Binding Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding Protein Dimerization Activity
	Biological Process	Brain Development Neuron Apoptotic Process	T Cell Mediated Cytotoxicity Negative Regulation Of T Cell Mediated Cytotoxicity Lymphangiogenesis Protein Phosphorylation Protein Dephosphorylation Response To Stress Lysosome Organization Signal Transduction Heart Development Learning Memory Regulation Of Gene Expression Dephosphorylation Calcium-ion Regulated Exocytosis Negative Regulation Of Signaling T Cell Differentiation Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Response To Cytokine Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus T Cell Proliferation T Cell Activation T Cell Homeostasis Negative Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Axon Extension Skeletal Muscle Fiber Development Regulation Of Insulin Secretion Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Antibacterial Innate Immune Response Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Lysosome Organization Negative Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways			DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation ROBO receptors bind AKAP5
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) Beef consumption ( 32066663) Lymphocyte percentage of white cells ( 32888494) Neuroticism ( 29255261) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		41 interacting genes: BDKRB2 CDC14A CDC25B CDK5 DUSP1 DUSP14 DUSP29 DUSP5 DUSP6 DUSP9 ERBB2 EYA2 EYA4 ILKAP MTMR10 MTMR6 MTMR8 MTMR9 PPM1A PPM1B PPM1F PPM1K PPM1M PPP1CA PPP3CA PPP3CB PTEN PTPDC1 PTPN11 PTPN12 PTPN18 PTPN20 PTPN6 PTPN7 PTPRR SBF1 STK39 STYX TAB1 TEPSIN TPTE2	20 interacting genes: AATK CABIN1 EGFR FBXL17 IRAK1 IRF2 JUN LMTK2 MARCHF7 MYOZ2 MYOZ3 NFATC2 PTK7 RCAN1 ROR2 RUNX1 SLC8A1 SLC8A2 SLC8A3 SOCS3
Entrez ID		9625	5532
HPRD ID		05591	00235
Ensembl ID		ENSG00000181409	ENSG00000107758
Uniprot IDs		H7C175 Q6ZMQ8	B7Z781 P16298
PDB IDs			4OR9 4ORA 4ORC
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Dephosphorylation Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Protein Serine/threonine Phosphatase Activity Hydrolase Activity Phosphate-containing Compound Metabolic Process Protein Tyrosine/serine/threonine Phosphatase Activity Protein Modification Process Peptidyl-tyrosine Dephosphorylation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Cytoplasm MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Negative Regulation Of Signaling Regulation Of Signal Transduction Cytosol Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Negative Regulation Of Cell Communication Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Phosphatase Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of MAPK Cascade Phosphatidylinositol Dephosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Peptidyl-threonine Dephosphorylation Negative Regulation Of Intracellular Signal Transduction Phospholipid Dephosphorylation Macromolecule Metabolic Process Intracellular Signaling Cassette Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Intracellular Signal Transduction ERK1 And ERK2 Cascade Manganese Ion Binding Cerebellar Cortex Formation Peptidyl-serine Dephosphorylation Phosphatidylinositol Metabolic Process Phosphatidylinositol-3,5-bisphosphate Phosphatase Activity MAPK Cascade N-terminal Protein Myristoylation ErbB-3 Class Receptor Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Negative Regulation Of Transport Nucleoplasm	Calcium:sodium Antiporter Activity Eyelid Development In Camera-type Eye Striated Muscle Cell Development Calcium:monoatomic Cation Antiporter Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Calcium Ion Import Across Plasma Membrane Calcium Ion Import Into Cytosol Regulation Of Cardiac Conduction Muscle Cell Development Regulation Of Signal Transduction Calcium Ion Import Regulation Of Calcineurin-mediated Signaling Calcium Ion Export Across Plasma Membrane FATZ Binding Negative Regulation Of Signal Transduction Protein Phosphatase Inhibitor Activity Transcription Factor AP-1 Complex Protein Kinase Activity Regulation Of Cell Communication Negative Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Signaling Telethonin Binding Axon Terminus Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Export Across Plasma Membrane Neuronal Cell Body Axon Negative Regulation Of Cardiocyte Differentiation Calcium Ion Transport Into Cytosol Negative Regulation Of Calcineurin-NFAT Signaling Cascade Calcium Ion Transmembrane Import Into Cytosol Cellular Developmental Process Regulation Of Calcium-mediated Signaling Inorganic Cation Import Across Plasma Membrane Antiporter Activity Negative Regulation Of Intracellular Signal Transduction Synapse Organization Postsynaptic Density Transcription Cis-regulatory Region Binding Calcineurin-NFAT Signaling Cascade Learning Or Memory Regulation Of Intracellular Signal Transduction Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of Smooth Muscle Cell Differentiation Cell Surface Receptor Signaling Pathway Sarcolemma Memory Intracellular Signaling Cassette Response To Muscle Stretch Coronary Vasculature Development
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