AATK and DUSP9

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		AATK	DUSP9
Description		apoptosis associated tyrosine kinase	dual specificity phosphatase 9
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endomembrane System Membrane Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity
	Biological Process	Brain Development Neuron Apoptotic Process	MAPK Cascade Protein Dephosphorylation Signal Transduction JNK Cascade Negative Regulation Of MAPK Cascade ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade
Pathways			RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) Beef consumption ( 32066663) Lymphocyte percentage of white cells ( 32888494) Neuroticism ( 29255261) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Body mass index ( 28892062) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31015462) Glomerular filtration rate ( 29403010) Hemoglobin A1c levels ( 29403010) Type 2 diabetes ( 20581827 22961080 23945395 30718926)
Interacting Genes		41 interacting genes: BDKRB2 CDC14A CDC25B CDK5 DUSP1 DUSP14 DUSP29 DUSP5 DUSP6 DUSP9 ERBB2 EYA2 EYA4 ILKAP MTMR10 MTMR6 MTMR8 MTMR9 PPM1A PPM1B PPM1F PPM1K PPM1M PPP1CA PPP3CA PPP3CB PTEN PTPDC1 PTPN11 PTPN12 PTPN18 PTPN20 PTPN6 PTPN7 PTPRR SBF1 STK39 STYX TAB1 TEPSIN TPTE2	7 interacting genes: AATK CDK4 GSK3B MAPK1 MAPK10 MAPK14 MAPK3
Entrez ID		9625	1852
HPRD ID		05591	02136
Ensembl ID		ENSG00000181409	ENSG00000130829
Uniprot IDs		H7C175 Q6ZMQ8	B2RAL9 Q6P9C2 Q99956
PDB IDs			2HXP 3LJ8
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Dephosphorylation Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Protein Serine/threonine Phosphatase Activity Hydrolase Activity Phosphate-containing Compound Metabolic Process Protein Tyrosine/serine/threonine Phosphatase Activity Protein Modification Process Peptidyl-tyrosine Dephosphorylation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Cytoplasm MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Negative Regulation Of Signaling Regulation Of Signal Transduction Cytosol Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Negative Regulation Of Cell Communication Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Phosphatase Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of MAPK Cascade Phosphatidylinositol Dephosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Peptidyl-threonine Dephosphorylation Negative Regulation Of Intracellular Signal Transduction Phospholipid Dephosphorylation Macromolecule Metabolic Process Intracellular Signaling Cassette Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Intracellular Signal Transduction ERK1 And ERK2 Cascade Manganese Ion Binding Cerebellar Cortex Formation Peptidyl-serine Dephosphorylation Phosphatidylinositol Metabolic Process Phosphatidylinositol-3,5-bisphosphate Phosphatase Activity MAPK Cascade N-terminal Protein Myristoylation ErbB-3 Class Receptor Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Negative Regulation Of Transport Nucleoplasm	Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity MAP Kinase Activity Kinase Activity ATP Binding Nucleotide Binding Transferase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Cellular Response To Cytokine Stimulus Lipopolysaccharide-mediated Signaling Pathway Interleukin-34-mediated Signaling Pathway Response To Cytokine Response To Peptide Regulation Of Golgi Inheritance MAPK Cascade Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Intracellular Transport Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Response To Lipopolysaccharide Insulin Receptor Signaling Pathway Response To Lipid Response To Molecule Of Bacterial Origin Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Protein Phosphorylation Intracellular Signaling Cassette Cellular Response To Tumor Necrosis Factor Bergmann Glial Cell Differentiation Phosphorylation Regulation Of Ossification Response To Tumor Necrosis Factor Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway MAP Kinase Kinase Activity Regulation Of Golgi Organization Pseudopodium Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Positive Regulation Of Macrophage Chemotaxis Regulation Of Cellular Localization Positive Regulation Of Neuroinflammatory Response Animal Organ Formation Positive Regulation Of Cyclase Activity Face Development Positive Regulation Of Cell Migration ERBB2 Signaling Pathway
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